Pituitary and Gonadal Effects of GnRH (Gonadotropin Releasing Hormone) Analogues in Two Peripubertal Female Rat Models

Pediatric Research

Volumn 55, Issue 1, 2004, Pages 126-133

  Roth, Christian ^a,c   Hegemann, Frank ^b   Hildebrandt, Judith ^b   Balzer, Ivonne ^b   Witt, Annette ^b   Wuttke, Wolfgang ^b   Jarry, Hubertus ^b  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CETRORELIX; DANAZOL; ESTRADIOL; FOLLITROPIN; GONADORELIN DERIVATIVE; GONADORELIN RECEPTOR; LUTEINIZING HORMONE; TRIPTORELIN;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ESTRADIOL BLOOD LEVEL; FEMALE; HORMONE INHIBITION; NONHUMAN; OVARIECTOMY; PRECOCIOUS PUBERTY; PREPUBERTY; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION;

ANDROGENS; ANIMALS; DANAZOL; DISEASE MODELS, ANIMAL; ESTROGEN ANTAGONISTS; FEMALE; GONADOTROPIN-RELEASING HORMONE; HORMONE ANTAGONISTS; HYPOTHALAMUS; LUTEOLYTIC AGENTS; OVARIECTOMY; OVARY; PITUITARY GLAND; PUBERTY, PRECOCIOUS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN; RECEPTORS, LHRH; TRIPTORELIN; UTERUS;

EID: 0346992207     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.PDR.0000100463.84334.3F     Document Type: Article

References (32)

1. Urbanski HF, Ojeda SR 1990 A role for N-methyl-D-aspartate (NMDA) receptors in the control of LH secretion and initiation of female puberty. Endocrinology 126:1774-1776
2. Moguilevsky JA, Carbone S, Szwarcfarb B, Rondina D 1991 Sexual maturation modifies the GABAergic control of gonadotrophin secretion in female rats. Brain Res 563:12-16
3. Bourguignon JP, Gérard A, Alvarez Gonzalez ML, Franchimont P 1992 Neuroendocrine mechanisms of onset of puberty. J Clin Invest 90:1736-1744
4. Rage F, Hill DF, Sena-Esteves M, Breakefield XO, Coffey RJ, Costa ME, McCann SM, Ojeda SR 1997 Targeting transforming growth factor alpha expression to discrete loci of the neuroendocrine brain induces female sexual precocity. Proc Natl Acad Sci U S A 94:2735-2740
5. Aubert ML, Pierroz DD, Gruaz NM, d'Alleves V, Vuagnat BA, Pralong FP, Blum WF, Sizonenko PC 1998 Metabolic control of sexual function and growth: role of neuropeptide Y and leptin. Mol Cell Endocrinol 140:107-113
6. Lebrethon MC, Vandersmissen E, Gerard A, Parent AS, Junien JL, Bourguignon JP 2000 In vitro stimulation of the prepubertal rat gonadotropin-releasing hormone pulse generator by leptin and neuropeptide Y through distinct mechanisms. Endocrinology 141:1464-1469
7. Crowley Jr WF, Comite F, Vale W, Rivier J, Loriaux DL, Cutler Jr GB 1981 Therapeutic use of pituitary desensitization with a long-acting LHRH agonist: a potential new treatment for idiopathic precocious puberty. J Clin Endocrinol Metab 52:370-372
8. Redding TW, Schally AV, Tice TR, Meyers WE 1984 Long-acting delivery systems for peptides: inhibition of rat prostate tumors by controlled release of [D-Trp6] luteinizing hormone-releasing hormone from injectable microcapsules. Proc Natl Acad Sci U S A 81:5845-5848
9. Plosker GL, Brogden RN 1994 Leuprorelin-a review of its pharmacology and therapeutic use in prostatic cancer, endometriosis and other sex hormone-related disorders. Drugs 48:930-967
10. Oostdijk W, Rikken B, Schreuder S, Otten B, Odink R, Rouwe C, Jansen M, Gerver WJ, Waelkens J, Drop S 1996 Final height in central precocious puberty after long term treatment with a slow release GnRH agonist. Arch Dis Child 75:292-297
11. Heger S, Partsch CJ, Sippell WG 1999 Long-term outcome after depot gonadotropin-releasing hormone agonist treatment of central precocious puberty: final height, body proportions, body composition, bone mineral density, and reproductive function. J Clin Endocrinol Metab 84:4583-4590
12. Partsch CJ, Heger S, Sippell WG 2002 Management and outcome of central precocious puberty. Clin Endocrinol (Oxf) 56:129-148
13. Beckers T, Marheineke K, Reiländer H, Hilgard P 1995 Selection and characterization of mammalian cell lines with stable over-expression of human pituitary receptors for gonadoliberin. Eur J Biochem 231:535-543
14. Roth C, Leonhardt S, Seidel C, Luft H, Wuttke W, Jarry H 2000 Comparative analysis of different puberty inhibiting mechanisms of two GnRH agonists and the GnRH antagonist cetrorelix using a female rat model. Pediatr Res 48:468-474
15. Friend KE, Ang LW, Shupnik MA 1995 Estrogen regulates the expression of several different estrogen receptor mRNA isoforms in rat pituitary. Proc Natl Acad Sci U S A 92:4367-4371
16. Gustafsson JA 1999 Estrogen receptor beta-a new dimension in estrogen mechanism of action. J Endocrinol 163:379-383
17. Kuiper GG, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, Gustafsson JA 1997 Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β Endocrinology 138:863-870
18. Schreihofer DA, Stoler MH, Shupnik MA 2000 Differential expression and regulation of estrogen receptors (ERs) in rat pituitary and cell lines: estrogen decreases ERalpha protein and estrogen responsiveness. Endocrinology 141:2174-2184
19. Roth C, Schricker M, Lakomek M, Strege A, Heiden I, Luft H, Munzel U, Wuttke W, Jarry H 2001 Autoregulation of the GnRH system during puberty: effects of antagonistic versus agonistic GnRH analogues in a female rat model. J Endocrinol 169:361-371
20. Morishita H, Takemoto M, Kondo H, Higuchi K, Aono T 1993 Induction of true precocious puberty by neonatal treatment with danazol in female rats. Neurosci Lett 157:33-36
21. Roth C, Leonhardt S, Theiling K, Lakomek M, Jarry H, Wuttke W 1998 Ontogeny of the GnRH-, glutaminase- and glutamate decarboxylase-gene expression in the hypothalamus of female rats. Brain Res Dev Brain Res 110:105-114
22. Sakamoto S, Tajima M, Sawaki K, Suzuki S, Kudo H, Sassa S, Kuwa K, Sugiura Y, Kasahara N, Nagasawa H 1993 Effects of luteinizing hormone-releasing hormone analogue on DNA synthesis in rat prostate and uterus. In Vivo 7:13-16
23. Haisenleder DJ, Cox ME, Parsons SJ, Marshall JC 1998 Gonadotropin-releasing hormone pulses are required to maintain activation of mitogen-activated protein kinase: role in stimulation of gonadotrope gene expression. Endocrinology 139:3104-3111
24. Loumaye E, Naor Z, Catt KJ 1982 Binding affinity and biological activity of gonadotropin releasing hormone agonists in isolated pituitary cells. Endocrinology 111:730-736
25. Tsutsumi M, Laws SC, Rodic V, Sealfon SC 1995 Translational regulation of the gonadotropin-releasing hormone receptor in alphaT3-1 cells. Endocrinology 136:1128-1136
26. Norwitz ER, Jeong KH, Chin WW 1999 Molecular mechanisms of gonadotropin-releasing hormone receptor gene regulation. J Soc Gynecol Investig 6:169-178
27. Nett TM, Turzillo AM, Baratta M, Rispoli LA 2002 Pituitary effects of steroid hormones on secretion of follicle-stimulating hormone and luteinizing hormone. Domest Anim Endocrinol 23:33-42
28. Kang SK, Choi KC, Cheng KW, Nathwani PS, Auersperg N, Leung PC 2000 Role of gonadotropin-releasing hormone as an autocrine growth factor in human ovarian surface epithelium. Endocrinology 141:72-80
29. Behre HM, Kliesch S, Pühse G, Reissmann T, Nieschlag E 1997 High loading and low maintenance doses of a gonadotropin-releasing hormone antagonist effectively suppress serum luteinizing hormone, follicle-stimulating hormone, and testosterone in normal men. J Clin Endocrinol Metab 82:1403-1408
30. Broqua P, Riviere PJ, Conn PM, Rivier JE, Aubert ML, Junien JL 2002 Pharmacological profile of a new, potent, and long-acting gonadotropin-releasing hormone antagonist: degarelix. J Pharmacol Exp Ther 301:95-102
31. Ashton WT, Sisco RM, Kieczykowski GR, Yang YT, Yudkovitz JB, Cui J, Mount GR, Ren RN, Wu TJ, Shen X, Lyons KA, Mao AH, Carlin JR, Karanam BV, Vincent SH, Cheng K, Goulet MT 2001 Orally bioavailable, indole-based nonpeptide GnRH receptor antagonists with high potency and functional activity. Bioorg Med Chem Lett 11:2597-2602
32. Millar RP, Zhu YF, Chen C, Struthers RS 2000 Progress towards the development of non-peptide orally-active gonadotropin-releasing hormone (GnRH) antagonists: therapeutic implications. Br Med Bull 56:761-772