Stereoselective adenylate deaminase (5′-adenylic acid deaminase, AMPDA)-catalyzed deamination of 5′-alkyl substituted adenosines: A comparison with the action of adenosine deaminase (ADA)

Tetrahedron Asymmetry

Volumn 15, Issue 2, 2004, Pages 203-206

  Ciuffreda, Pierangela ^a   Loseto, Angela ^a   Santaniello, Enzo ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

5' BUTYL 2',3' ISOPROPYLIDENE ADENOSINE; ADENOSINE DEAMINASE; ADENOSINE DERIVATIVE; ADENOSINE MONOPHOSPHATE DEAMINASE; ADENYLATE DEAMINASE (5' ADENYLIC ACID DEAMINASE); ENZYME; INOSINE DERIVATIVE; METHYL 2',3' ISOPROPYLIDENE ADENOSINE; METHYL GROUP; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; COMPARATIVE STUDY; DEAMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; ISOMER; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; STEREOSPECIFICITY;

EID: 0346969548     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetasy.2003.11.007     Document Type: Article

References (12)

1. Ciuffreda P., Loseto A., Santaniello E. Tetrahedron. 58:2002;5767-5771.
2. Ciuffreda P., Loseto A., Santaniello E. Tetrahedron: Asymmetry. 13:2002;239-241.
3. Chládek S., Smrt J. Collect. Czech. Chem. Commun. 29:1964;214-232.
4. 3).
5. Vrudhula V.M., Kappler F., Afshar C., Ginell S.L., Lessinger L., Hampton A. J. Med. Chem. 32:1989;885-890.
6. Shuto S., Obara T., Toriya M., Hosoya M., Snoeck R., Andrei G., Balzarini J., De Clercq E. J. Med. Chem. 35:1992;324-331.
7. Ranganathan R.S., Jones G.H., Moffatt J.G. J. Org. Chem. 39:1974;290-297.
8. 3).
9. 3 CN, 7:3). When the reaction was complete, the solution was lyophilized to afford inosines 4b,c.
10. 3).
11. 3).
12. ′-butyl chain protons (Δδ>0) were in agreement with the proposed R-configuration.