The effects of citric acid (antioxidant) and benzoic acid (antimicrobial agent) on the mouse liver: Biochemical and histopathological study

Biologia - Section Cellular and Molecular Biology

Volumn 58, Issue 3, 2003, Pages 343-347

  Aktac, Tulin ^a   Kaboglu, Aysegul ^a   Ertan, Figen ^a   Ekinci, Filiz ^a   Huseyinova, Gulara ^a  

^a TRAKYA UNIVERSITY   (Turkey)

Author keywords

Benzoic acid; Catalase; Citric acid; Food preservatives; Liver; Mouse; Uricase

Indexed keywords

EID: 0346958336     PISSN: 13356399     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. AKSNES, A. & NJAA, R. L. 1991. Catalase, glutathione peroxidase and superoxide dismutase in different fish species. Comp. Biochem. Physiol. 69: 893-896.
2. ATLAS, R. M. 1984. Microbiology: Fundamental and Applications. Mac Millan Company, 336 pp.
3. CABEL, M. C., WALDROUP, P. W., SHERMER, W. D. & CALABOTTA, D. F. 1988. Effects of ethoxyquin feed preservative and peroxide level on broiler performance. Poultry Science 67: 1725-1730.
4. DANIEL, J. W. 1986. Metabolic aspects of antioxidants and preservatives. Xenobiotica 16: 10-11.
5. FUJITANI, T. 1993. Short-term effect of sodium benzoate in F344 rats and B6C3F1 mice. Toxicol. Lett. 69: 171-179.
6. JUNG, R., COJOCEL, C., MULLER, W., BOTTGER, D. & LUCK, E. 1992. Evaluation of the genotoxic potential of sorbic acid and potassium sorbate. Food Chem. Toxicol. 30: 1-7.
7. KABOGLU, A. & AKTAC, T. 2002. A study of the effects of the Na-benzoate on the mouse liver. Biologia, Bratislava, 57: 373-380.
8. KAGAN, V. E., SERBINOVA, E. A., PACKER, L. 1990. Generation and recycling of radicals from phenolic antioxidants. Arch. Biochem. Biophys. 280: 33-39.
9. KINSELLA, J. E., GERMAN, B. & SHETTY, J. 1985. Uricase from liver: Isolation and some properties. Comp. Biochem. Physiol. 82: 621-624.
10. KOYOMA, M., MASAHIKO, M., ISHIDA, T., TETSUO, T., HORIKE, K., NOZAKI, M. & SHIMADA, M. 1991. Urate oxidase activity and copper content in the liver of macular mutant mouse, a model animal for human congenital copper deficiency Menke's Kinky Hair disease, J. Nutr. Sci. Vitaminol. 37: 601-609.
11. MC FARLANE, M., PRICE, S. C., COTTREL, S., GRASSO, P., BREMMER, J. N., BOMHARD, M. E. & HINTON, H. R. 1997. Hepatic and associated response of rats to pregnancy, lactation and simultaneous treatment with butylated hydroxytoluene. Food Chem. Toxicol. 35: 753-767.
12. MAKOVEC, P. & SINDELAR, L. 1984. The effect of phenolic compounds on the activity of respiratory chain enzymes and on respiration and phosphorylation activities of potato tuber mitochondria. Biol. Plant. 26: 415-422.
13. NIJHOFF, W. A. & PETERS, W. H. M. 1992. Induction of rat hepatic and intestinal glutathione S-transferases by butylated hydroxyanisole. Biochem. Pharmacol. 44: 596-600.
14. SAFER, A. M. & NUGHAMISH, A. J. 1999. Hepatotoxicity induced by the antioxidant food additive butylated hydroxytoluene (BHT) in rats: an electron microscopical study. Histol. Histopathol. 14: 391-406.
15. WEEMAES, C. A., DE-CORDT, S. V., LUDIKHUYZE L. R., VAN DEN BROECK, I., HENDRICKX, M. E. & TOBBACK, P. P. 1997. Influence of pH, benzoic acid, EDTA, and glutathione on the pressure and/or temperature inactivation kinetics of mushroom polyphenoloxidase. Biotechnol. Prog. 13: 25-32.
16. WURTZEN, G. 1990. Shortcomings of current strategy for toxicity testing of food chemicals: antioxidants. Food Chem. Toxicol. 28: 743-745.