Gentamicin and CFTR [5]

New England Journal of Medicine

Volumn 349, Issue 26, 2003, Pages 2570-

  Kida, Yujiro ^a  

^a TOKYO METROPOLITAN KOMAGOME HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC G 418; CYCLIC AMP; GENTAMICIN; PLACEBO; TRANSMEMBRANE CONDUCTANCE REGULATOR; ANTIINFECTIVE AGENT; CFTR PROTEIN, HUMAN;

APICAL MEMBRANE; CYSTIC FIBROSIS; DRUG MECHANISM; HUMAN; LETTER; NOSE MUCOSA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STOP CODON; CELL MEMBRANE POTENTIAL; DRUG COMBINATION; DRUG EFFECT; METABOLISM; NOTE;

ANTI-BACTERIAL AGENTS; CYCLIC AMP; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DRUG THERAPY, COMBINATION; GENTAMICINS; HUMANS; MEMBRANE POTENTIALS; NASAL MUCOSA;

EID: 0346887191     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM200312253492621     Document Type: Letter

References (4)

1. Wilschanski M, Yahav Y, Yaacov Y, et al. Gentamicin-induced correction of CFTR function in patients with cystic fibrosis and CFTR stop mutations. N Engl J Med 2003;349:1433-41.
2. Bedwell DM, Kaenjak A, Benos DJ, et al. Suppression of CFTR premature stop mutation in a bronchial epithelial cell line. Nat Med 1997;3:1280-4.
3. Bradbury NA, Jilling T, Berta G, Sorscher EJ, Bridges RJ, Kirk KL. Regulation of plasma membrane recycling by CFTR. Science 1992;256:530-2.
4. Prince LS, Workman RB Jr, Marchase RB. Rapid endocytosis of the cystic fibrosis transmembrane conductance regulator chloride channel. Proc Natl Acad Sci U S A 1994;91:5192-6.