Synthesis and biological evaluation of [4-(2-phenylethenesulfonylmethyl) phenyl]-quinazolin-4-yl-amines as orally active anti-cancer agents

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 1, 2004, Pages 67-71

  Sharma, Vedula M ^a   Seshu, K V Adi ^a   Sekhar, V Chandra ^a   Madan, Sachin ^a   Vishnu, B ^a   Babu, P Aravind ^a   Krishna, C Vamsee ^a   Sreenu, J ^a   Krishna, V Ravi ^a   Venkateswarlu, A ^a   Rajagopal, Sriram ^a   Ajaykumar, R ^a   Kumar, T Sravan ^a  

^a DR REDDY'S LABORATORIES LTD   (India)

Author keywords

HT 29 human colon adeno carcinoma xenograft; Orally active anti cancer agents; 4 (2 Phenylethenesulfonylmethyl)phenyl quinazolin 4 yl amines

Indexed keywords

ANTINEOPLASTIC AGENT; QUINAZOLINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; COLON ADENOCARCINOMA; CONTROLLED STUDY; DEPROTECTION REACTION; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TUMOR XENOGRAFT;

EID: 0346887172     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.10.020     Document Type: Article

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14. +, 100%); CHN: calcd C 65.86%; H 4.33%; N 10.02%. Found C 65.80%; H 4.27%; N 10.30%.