Ion channels in drug discovery and development

Drug Discovery Today

Volumn 8, Issue 22, 2003, Pages 1022-1024

  Mathes, Chris ^a  

^a High throughput Electrophysiology S   (United States)

Author keywords

Automation; Drug Discovery; HERG; Ion channels; Patch clamp systems; Pharmaceutical Science; Targets; Techniques Methods

Indexed keywords

2 AMINO 3 PHOSPHONOPROPIONIC ACID; ANTIHISTAMINIC AGENT; ASTEMIZOLE; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL N TYPE; CALCIUM CHANNEL R TYPE; CISAPRIDE; GLASS; ION CHANNEL; MORPHINE; NEUROLEPTIC AGENT; POTASSIUM; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; SILICON; SILICON DIOXIDE; SODIUM; SODIUM CHANNEL; TERFENADINE; VERAPAMIL; VOLTAGE GATED CALCIUM CHANNEL;

ACTION POTENTIAL; AUTOIMMUNE DISEASE; CELL GROWTH; CELL LINE; CELL MEMBRANE; CELL STRAIN 3T3; CHO CELL; CONFERENCE PAPER; CYSTIC FIBROSIS; DRUG ACTIVITY; ELECTRODE; ELECTROPHYSIOLOGY; ENDOPLASMIC RETICULUM; EVOKED RESPONSE AUDIOMETRY; HUMAN; IC 50; LONG QT SYNDROME; MICROPIPETTE; MULTIPLE SCLEROSIS; NEUROBLASTOMA; NONHUMAN; PAIN; PATCH CLAMP; PHENOTYPE; PRESYNAPTIC INHIBITION; SIDE EFFECT; SYNCOPE; T LYMPHOCYTE; TUMOR GROWTH;

ANIMALS; AUTOMATION; DRUG DESIGN; DRUG EVALUATION; HUMANS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; TECHNOLOGY, PHARMACEUTICAL;

EID: 0346881208     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(03)02875-7     Document Type: Conference Paper

References (3)

1. Neher E., Sakmann B. Single-channel currents recorded from membrane of denervated frog muscle fibres. Nature. 260:1976;799-802.
2. Hamill O.P., et al. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch. 391:1981;85-100.
3. Kostyuk P.G., et al. Effect of internal fluoride and phosphate on membrane currents during intracellular dialysis of nerve cells. Nature. 257:1975;691-693.