In vitro interferon-gamma release test in the diagnosis of drug-induced erythema nodosum

Israel Medical Association Journal

Volumn 6, Issue 1, 2004, Pages 59-60

  Halevy, Sima ^a,b   Gold, Isaac ^c   Cohen, Arnon D ^a,b   Grossman, Nili ^a,b  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^c ASSAF HAROFEH MEDICAL CENTER   (Israel)

Author keywords

Adverse drug reaction; Drug induced; Erythema nodosum; Interferon gamma; Th1 type cytokine

Indexed keywords

CYTOKINE; ESTRADIOL VALERATE PLUS NORGESTREL; GAMMA INTERFERON; PARACETAMOL; PROGESTERONE;

ARTICLE; CLINICAL ARTICLE; CYTOKINE RELEASE; DIAGNOSTIC TEST; DRUG INDUCED DISEASE; DRUG WITHDRAWAL; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHEMA; ERYTHEMA NODOSUM; FEMALE; HISTOPATHOLOGY; HUMAN; IN VITRO STUDY; LEG; MALE; PAIN; PERIPHERAL LYMPHOCYTE; SUPPOSITORY; T LYMPHOCYTE ACTIVATION; TABLET;

CASE-CONTROL STUDIES; DIAGNOSIS, DIFFERENTIAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; ERYTHEMA NODOSUM; ESTRADIOL; FEMALE; HUMANS; INTERFERON TYPE II; LYMPHOCYTES; MALE; MIDDLE AGED; TIME FACTORS;

EID: 0346801825     PISSN: 15651088     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

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2. Bork K, ed. Erythema nodosum. In: Cutaneous Side Effects of Drugs. Philadelphia: WB Saunders, 1998:146-8.
3. Halevy S. In-vitro tests for adverse drug reactions based on cytokine release. In Kauppinen K, Alanko K, Hannuksela M, Maibach H, eds. Skin Reactions to Drugs. Boca Raton, FL: CRC Press LLC, 1998:119-31.
4. Halevy S, Cohen AD, Lunenfeld E, Grossman N. Autoimmune progesterone dermatitis manifested as erythema annulare centrifugum: Confirmation of progesterone sensitivity by in vitro interferon-gamma release. J Am Acad Dermatol 2002;47:311-13.
5. Llorente L, Richaud PY, Alvarado C, Reyes E, Alcocer VJ, Orozco TR. Elevated Th1 cytokine mRNA in skin biopsies and peripheral circulation in patients with erythema nodosum. Eur Cytokine Netw 1997;8:67-71.