The CAG repeat polymorphism in the androgen receptor gene (AR) and its relationship to head and neck cancer

Oral Oncology

Volumn 40, Issue 2, 2004, Pages 177-182

  Dos Santos, M L ^a   Sibov, T T ^a   Nishimoto, I N ^b   Kowalski, L P ^b   Miracca, E C ^a   Nagai, M A ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b A C CAMARGO CANCER CENTER   (Brazil)

Author keywords

Androgen receptor; CAG repeat; Head and neck

Indexed keywords

ANDROGEN RECEPTOR; GENOMIC DNA;

ADULT; AGED; ALLELE; ARTICLE; CANCER RISK; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA DENATURATION; DNA POLYMORPHISM; GEL ELECTROPHORESIS; GENE AMPLIFICATION; GENE SEQUENCE; GENETIC ASSOCIATION; HEAD CANCER; HUMAN; HUMAN TISSUE; LARYNX CANCER; MAJOR CLINICAL STUDY; MALE; MOUTH CARCINOMA; NECK CANCER; PRIORITY JOURNAL;

EID: 0346789062     PISSN: 13688375     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1368-8375(03)00149-0     Document Type: Article

References (30)

1. Spitz M.R. Epidemiology and risk factors for head and neck cancer. Semin Oncol. 21(3):1994;281-288.
2. Blot W.J., McLaughlin J.K., Winn D.M., Austin D.F., Greenberg R.S., Preston-Martin S.et al. Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Res. 48(11):1988;3282-3287.
3. Wünsch-Filho V. The epidemiology of oral and pharynx cancer in Brazil. Oral Oncol. 38:2002;737-746.
4. La Vecchia C., Tavani A., Franceschi S., Levi F., Corrao G., Negri E. Epidemiology and prevention of oral cancer. Oral Oncol. 33(5):1997;302-312.
5. Cattaruzza M.S., Maisonneuve P., Boyle P. Epidemiology of laryngeal cancer. Oral Oncol, Eur J Cancer. 32B(5):1996;293-305.
6. Jenster G. The role of the androgen receptor in the development and progression of prostate cancer. Semin Oncol. 26:1999;407-421.
7. Sommer S., Fuqua S.A. Estrogen receptor and breast cancer. Semin Cancer Biol. 11(5):2001;339-352.
8. Saez S., Sakai F. Androgen receptors in human pharyngo-laryngeal mucosa and pharyngo-laryngeal epithelioma. J Steroid Biochem. 7(11-12):1976;919-921.
9. Vecerina-Volic S., Romic-Stojkovic R., Krajina Z., Gamulin S. Androgen receptors in normal and neoplastic laryngeal tissue. Arch Otolaryngol Head Neck Surg. 113(4):1987;411-413.
10. Lu S., Tsai S.Y., Tsai M.J. Regulation of androgen-dependent prostatic cancer cell growth. androgen regulation of CDK2, CDK4, and CKI p16 genes Cancer Res. 57(20):1997;4511-4516.
11. Brown T.R., Lubahn D.B., Wilson E.M., Joseph D.R., French F.S., Migeon C.J. Deletion of the steroid-binding domain of the human androgen receptor gene in one family with complete androgen insensitivity syndrome. evidence for further genetic heterogeneity in this syndrome Proc. Natl. Acad. Sci. U.S.A. 85(21):1988;8151-8155.
12. Fujigasaki H., Martin J.J., De Deyn P.P., Camuzat A., Deffond D., Stevanin G.et al. CAG repeat expansion in the TATA box-binding protein gene causes autosomal dominant cerebellar ataxia. Brain. 124(10):2001;1939-1947.
13. Bruce H.A., Margolis R.L. FOXP2. novel exons, splice variants, and CAG repeat length stability Hum Genet. 111(2):2002;136-144.
14. Giovannucci E., Stampfer M.J., Krithivas K., Brown M., Dahl D., Brufsky A.et al. The CAG repeat within the androgen receptor gene and its relationship to prostate cancer. Proc. Natl. Acad. Sci. U.S.A. 94:1997;3320-3323.
15. Ingles S.A., Ross R.K., Yu M.C., Irvine R.A., La Pera G., Haile R.W.et al. Association of prostate cancer risk with genetic polymorphisms in vitamin D receptor and androgen receptor. J Natl Cancer Inst. 89:1997;166-170.
16. Hardy D.O., Scher H.I., Bogenreider T., Sabbatini P., Zhang Z.F., Nanus D.M.et al. Androgen receptor CAG repeat lengths in prostate cancer: correlation with age of onset. J. Clin. Endocrinol. Metab. 81:1996;4400-4405.
17. Latil A.G., Azzouzi R., Cancel G.S., Guillaume E.C., Cochan-Priollet B., Berthon P.L.et al. Prostate carcinoma risk and allelic variants of genes involved in androgen biosynthesis and metabolism pathways. Cancer. 92:2001;1130-1137.
18. La Spada A.R., Wilson E.M., Lubahn D.B., Harding A.E., Fischbeck K.H. Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature. 352:1991;77-79.
19. Rebbeck T.R., Kantoff P.W., Krithivas K., Neuhausen S., Blackwood M.A., Godwin A.K.et al. Modification of BRCA1-associated breast cancer risk by the polymorphic androgen-receptor CAG repeat. Am J Hum Genet. 64(5):1999;1371-1377.
20. Giguere Y., Dewailly E., Brisson J., Ayotte P., Laflamme N., Demers A.et al. Short polyglutamine tracts in the androgen receptor are protective against breast cancer in the general population. Cancer Res. 61(15):2001;5869-5874.
21. Chamberlain N.L., Driver E.D., Miesfeld R.L. The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. Nucleic Acids Res. 22:1994;3181-3186.
22. Beilin J., Ball E.M., Favaloro J.M., Zajac J.D. Effect of the androgen receptor CAG repeat polymorphism on transcriptional activity. specificity in prostate and non-prostate cell lines J. Mol. Endocrinol. 25(1):2000;85-96.
23. Kazantsev A., Preisinger E., Dranovsky A., Goldgaber D., Housman D. Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 96(20):1999;11404-11409.
24. Hsing A.W., Chokkalingam A.P., Gao Y.T., Wu G., Wang X., Deng J.et al. Polymorphic CAG/CAA repeat length in the AIB1/SRC-3 gene and prostate cancer risk: a population-based case-control study. Cancer Epidemiol Biomarkers Prev. 11(4):2002;337-341.
25. Umekita Y., Hiipakka R.A., Kokontis J.M., Liao S. Human prostate tumor growth in athymic mice. inhibition by androgens and stimulation by finasteride Proc. Natl. Acad. Sci. U.S.A. 93(21):1996;11802-11807.
26. Kokontis J.M., Liao S. Molecular action of androgen in the normal and neoplastic prostate. Vitam Horm. 55:1999;219-307.
27. Choong C.S., Kemppainen J.A., Zhou Z.X., Wilson E.M. Reduced androgen receptor gene expression with first exon CAG repeat expansion. Mol. Endocrinol. 10(12):1996;1527-1535.
28. Waltregny D., Leav I., Signoretti S., Soung P., Lin D., Merk F.et al. Androgen-driven prostate epithelial cell proliferation and differentiation in vivo involve the regulation of p27. Mol. Endocrinol. 15(5):2001;765-782.
29. Ando S., De Amicis F., Rago V., Carpino A., Maggiolini M., Panno M.L.et al. Breast cancer: from estrogen to androgen receptor. Mol. Cell. Endocrinol. 193(1-2):2002;121-128.
30. Gray A., Berlin J.A., McKinlay J.B., Longcope C. An examination of research design effects on the association of testosterone and male aging. results of a meta-analysis J Clin Epidemiol. 44(7):1991;671-684.