Study of the Binding of Iron and Indium to Human Serum Apo-Transferrin

Iranian Biomedical Journal

Volumn 7, Issue 2, 2003, Pages 73-77

  Moshtaghie, Ali Asghar ^a   Ghaffari, Mohammad Ali ^b  

^a ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Indium; Iron; Spectrophotometry; Transferrin

Indexed keywords

CITRIC ACID; INDIUM; IRON; TRANSFERRIN;

ARTICLE; COMPLEX FORMATION; EQUILIBRIUM CONSTANT; METAL BINDING; PH; SERUM; SPECTROPHOTOMETRY;

EID: 0346749814     PISSN: 1028852X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Chapin, R.E., Harris, M.W., Sidney Hunter, H.E., Davis, B.J., Collins, B.J. and Lockhart, A.C. (1995) The reproductive and development toxicity of indium in the Swiss mouse. Fundam. Appl. Toxicol. 27: 140-148.
2. Blazkd, M.E., Dixon, D., Haskins, E. and Rosenthal, C.G. (1994) Pulmonary toxicity to intra-tracheally administered indium trichloride in Fischer 344 rats. Fundam. Appl. Toxicol. 22: 231-239.
3. Suzuki, Y. and Matsushita, H. (1969) Interaction of metal ions with phospholipid monolayer and their acute toxicity. Ind. Health 7: 143-154.
4. Woods, J.S., Carver, G.T. and Fowler, B.A. (1979) Altered regulation of hepatic hem metabolism by indium chloride. Toxicol. Appl. Pharmacol. 49: 455-461.
5. Woods, J.S. and Fowler, B.A. (1982) Selective inhibition of delta amino-levulinic acid dehydratase by indium chloride in rat kidney: Biochemical and ultrastructural studies. Exp. Mol. Pathol. 36: 306-315.
6. MacGillivray, R.T.A., Mendez, E., Schewale, J.G., Sinha, S.K., Lineback, S.J. and Brew, K. (1983) The primary structure of human serum transferrin. J. Biol. Chem. 258: 3545-3553.
7. Moshtaghie, A.A. and Skillen, A.W. (1986) Binding of aluminium to transferrin and lactoferrin. Biochem. Soc. Transactions. 14: 916-917.
8. Moshtaghie, A.A., Ani, M. and Bazrafshan, M. (1992) comparative binding study of aluminium and chromium to human transferrin. Biol. Trace. Elem. Res. 32: 39-46.
9. Harris, W.R. and Pecraro, V.L. (1983) Thermodynamic binding constants for gallium transferrin. Biochemistry 22: 292-299.
10. Moshtaghie, A.A. and Badii, A. (1996) Comparative binding studies of zinc and iron to human serum transferrin. Iran. J. Sci. Tech. 20: 177-188.
11. Brittenham, G. (1979) Spectrophotometric plasma iron determination from finger puncture specimens. Clin. Chim. Acta. 91: 203-211.
12. Scatchard, G. (1984) The interaction of proteins for small molecules and ions. Ann. New Acad. Sci. 51: 660-675.
13. Punnonen, K., Irjala, K. and Rajamaki, A. (1994) Iron deficiency anemia is associated with high concentration of transferrin receptor in serum. Clin. Chem. 40: 774-776.
14. Aisen, P. (1966) Studies on the binding of iron to transferrin and conalbumin. J. Biol. Chem. 241: 1666-1671.
15. Aisen, P., Aasa, R. and Redfield, A.G. (1969) The chromium, manganese and cobalt complexes of transferrin. J. Biol. Chem. 244: 4628-4633.
16. Battistuzzi, G., Calzolai, L., Messori, L. and Sola, M. (1995) Metal induced conformational heterogeneity of transferrins: A spectroscopic study of indium (III) and other metal (III) substituted transferrins. Biochem. Biophys. Res. Commun. 206: 161-170.
17. Li, H., Sadler, P.J. and Sun, H. (1996) Unexpectedly strong binding of a large metal ion (Bi) to human serum transferrin. J. Biol. Chem. 271: 9483-9489.
18. Lastas, A.W. (1976) Effect of pH upon human transferrin. Selective labeling of the two iron binding sites. British J. Haematol. 32: 341-349.
19. Ponka, P. (1997) Tissue specific regulation of iron metabolism and hem synthesis: Distinct control metabolism in erythroid cells. Blood 89: 1-25.