2-Methyltetrahydrofuran as an Alternative to Dichloromethane in 2-Phase Reactions

Synlett

Volumn , Issue 15, 2003, Pages 2353-

  Brown Ripin, David H ^a   Vetelino, Michael ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

2 methyltetrahydrofuran; Biphasic reaction; Schotten Baumann; Solvent

Indexed keywords

2 METHYLTETRAHYDROFURAN; DICHLOROMETHANE; SOLVENT; TETRABUTYLAMMONIUM; TETRAHYDROFURAN DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; AMIDATION; ARTICLE; CATALYST; CHEMICAL REACTION; REACTION TIME; SOLUBILITY; SUBSTITUTION REACTION;

EID: 0346749668     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-42091     Document Type: Article

References (3)

1. 2O (100.0 mL), 50% aq NaOH (5.000 equiv, 1.328 mol, 106.2 mL), and heat to a temperature of 75°C. Stir for 2 h at 75°C, then cool to a temperature of 20°C. Split the phases. Concentrate the organic layer to an oil to afford 54.31 g (252.4 mmol, 95.00% of theoretical yield) of 2-nitrophenyl phenyl ether.
2. Vlasov, V. M. Russian J. Org. Chem. 1998, 34(9), 1310.
3. Jones, R. A. Aldrichimica Acta 1976, 9(3), 35.