Morphological Observations on Antitumor Activities of 70 kDa Fragment in α-Subunit from Pronase-Treated Ovomucin in a Double Grafted Tumor System

Food Science and Technology Research

Volumn 6, Issue 3, 2000, Pages 179-185

  Oguro, Tatsuo ^a   Watanabe, Kenji ^a   Tani, Hisanori ^b   Ohishi, Hifumi ^b   Ebina, Takusaburo ^c  

^a GIFU UNIVERSITY   (Japan)

^b Nishitama gun   (Japan)

^c MIYAGI CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Antitumor effect; Glycoprotein; Meth A tumor cells; Ovomucin

Indexed keywords

EID: 0346743235     PISSN: 13446606     EISSN: None     Source Type: Journal    
DOI: 10.3136/fstr.6.179     Document Type: Article

References (24)

1. Basilico, C. and Moscatelli, D. (1992). The FGF family of growth factors and oncogenes. Adv. Cancer Res., 159, 115-165.
2. Cozzolino, F., Toreia, M., Aldinucci, D., Ziche, M., Almerigogna, F., Bani, D. and Stern, D.M. (1990). Interleukin 1 is an autocrine regulator of human endothelial cell growth, Proc. Natl. Acad. Sci. USA, 87, 6487-6491.
3. Dong, Z., Kumar, R., Yang, X. and Filder, I.J. (1997). Macrophage-derived metalloelastase is responsible for generation of angiostatin in Lewis lung carcinoma. Cell, 88, 801-810.
4. Ebina, T., Kohya, H., Yamaguchi, T. and Ishida, N. (1986). Antimetastatic effect of biological response modifiers in the "double grafted tumor system." Jpn. J. Cancer Res., 77, 1034-1042.
5. Ebina, T. and Kohya, H. (1988). Antitumor effect mechanism at a distant site in the double grafted tumor system of PSK, a protein-bound polysaccaride preparation. Jpn. J. Cancer Res., 79, 957-964.
6. Ebina, T., Kohya, H. and Ishikawa, K. (1989). Antitumor effect of PSK: Role of regional lymph nodes and enhancement of concomitant and sinecomitamt immunity in the mouse. Jpn. J. Cancer Res., 80, 158-166.
7. Folkman, J. (1972). Anti-angiogenesis: New concept for therapy of solid tumors. Ann. Surg., 175, 409-416.
8. Folkman, J. and Klagsbrun, M. (1987). Angiogenic factors. Science, 235, 442-447.
9. Gately, S., Twardowski, P., Stack, M.S., Cundiff, D.L., Grella, D., Castellino, F.J., Enghild, J., Kwaan, H.C., Lee, F., Kramer, R.A., Volpert, O., Buck, N. and Soff, G.A. (1997). The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitior angiostatin. Proc. Natl. Acad. Sci. USA, 94, 10868-10872.
10. Hayakawa, S. and Sato, Y. (1977). Physicochemical identity of α-ovomucin or β-ovomucin obtained from the sonicated insoluble and soluble ovomucin. Agric. Biol. Chem., 41, 1185-1191.
11. Kamiya, H., Muramoto, K. and Yamazaki, M. (1986). Aplysian A, an antibacteria and antineopiastic glycoprotein in the albumen gland of sea-hare, Aplysian Kurodai. Experientia (Basle), 42, 1065-1067.
12. Kato, A., Nakamura, R. and Sato, Y. (1970), Studies on changes in stored shell eggs. Part VI. Changes in the chemical composition of ovomucin during storage, Agric. Biol. Chem., 34, 1009-1013.
13. Kato, A., Ogino K., Matsudomi, N. and Kobayashi, K. (1977). Separation of ovomucin into carbohydrate rich and poor components by chromatography on lysozyme-Sepharose 4B. Agric. Biol. Chem., 41, 1925-1929.
14. Kisugi, J., Kamiya, H. and Yamazaki, M. (1987). Purification and characterization of aplysianin E, and antitumor factor from sea eggs. Cancer Res., 47, 5649-5653.
15. Ohami, H., Ohishi, H., Yokota, T., Mori, T. and Watanabe, K. (1993). Cytotoxic effect of sialoglycoprotein derived from avian egg white ovomucin on the cultured tumor cell. Med. Biol., 126, 19-23.
16. Plate, K.H., Breier, G., Welch, H.A. and Risau, W. (1992). Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature, 359, 845-848.
17. Shimizu, M., Tanimoto, H., Azuma, N. and Yamauchi, K. (1990). Growth inhibition of BALB/c 3T3 cells by a high-molecule-weight mucin-like glycoprotein of human milk fat globule membrane. Biochem. Intern, 20, 147-154.
18. Tanizaki, H., Tanaka, H., Iwata, H. and Kato, A. (1997). Activation of macrophages by sulfated glycopeptides in ovomucin, yolk membrane, and chalazae in chicken eggs. Biosci. Biotechnol. Biochem., 61, 1883-1889.
19. Tsuge, Y., Shimoyamada, M. and Watanabe, K. (1997a). Structural features of Newcastle disease virus- and anti-ovomucin antibody-binding glycopeptides from pronase-treated ovomucin. J. Agric. Food Chem., 45, 2393-2398.
20. Tsuge, Y., Shimoyamada, M. and Watanabe, K. (1997b). Binding of ovomucin to Newcastle disease virus and anti-ovomucin antibodies, and its heat stability based on binding abilities. J. Agric. Food Chem., 45, 4629-634.
21. Watanabe, K., Tsuge, Y., Shimoyamada, M., Ogama, N. and Ebina, T. (1998a). Antitumor effects of pronase-treated fragments, glycopeptide, from ovomucin in hen egg white in a double grafted tumor system. J. Agric. Food Chem., 46, 3033-3038.
22. Watanabe, K., Tsuge, Y and Shimoyamada, M. (1998b). Binding activities of pronase-treated fragments from egg white ovomucin with anti-ovomucin antibodies and newcastle disease virus. J. Agric. Food Chem., 46, 4501-4506.
23. Yokota, T., Ohishi, H. and Watanabe, K. (1999a). In vitro studies of cytotoxic effect on sarcoma-180 cells of β-subunit from egg white ovomucin. Food Sci. Technol. Res., 5, 273-278.
24. Yokota, T., Ohishi, H. and Watanabe K. (1999b). Amitumor effects of β-subunit from egg white ovomucin on xenografted sarcoma-180 cells in mice. Food Sci. Technol. Res., 5, 279-283.