Expression of a Human Surfactant Protein C Mutation Associated with Interstitial Lung Disease Disrupts Lung Development in Transgenic Mice

Journal of Biological Chemistry

Volumn 278, Issue 52, 2003, Pages 52739-52746

  Bridges, James P ^a   Wert, Susan E ^a   Nogee, Lawrence M ^b   Weaver, Timothy E ^a  

^a Cincinnati Childrens Hosp Med Ctr   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; DNA; GENES; GENETIC ENGINEERING; LIPIDS; MUTAGENESIS; PULMONARY DISEASES; SURFACE TENSION; TISSUE;

BIOCHEMICAL PATHWAYS; EPITHELIAL CELLS; GENE ENCODING;

PROTEINS;

ADENINE; COMPLEMENTARY DNA; GUANINE; SURFACTANT PROTEIN C;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; EMBRYO; ENDOPLASMIC RETICULUM; GENE LOCUS; GENE MUTATION; GENETIC TRANSFECTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; INTERSTITIAL LUNG DISEASE; LUNG DEVELOPMENT; LUNG VOLUME; MORPHOGENESIS; MOUSE; NONHUMAN; PEDIGREE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; SFTPC GENE; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; BLOTTING, WESTERN; CARRIER PROTEINS; CELL LINE; DNA; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; EXONS; GENE DELETION; HEAT-SHOCK PROTEINS; HUMANS; LIPID METABOLISM; LUCIFERASES; LUNG; LUNG DISEASES; MICE; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; MODELS, GENETIC; MOLECULAR CHAPERONES; MUTATION; PEPTIDES; PHENOTYPE; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN TRANSPORT; PULMONARY SURFACTANT-ASSOCIATED PROTEIN C; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TRANSGENES;

ANIMALIA; MUS MUSCULUS;

EID: 0346732280     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M309599200     Document Type: Article

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