Effect of Parenteral Fluoroquinolone Administration on Persistence of Vancomycin-Resistant Enterococcus faecium in the Mouse Gastrointestinal Tract

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 1, 2004, Pages 326-328

  Donskey, Curtis J ^a,b   Helfand, Marion S ^a   Pultz, Nicole J ^a   Rice, Louis B ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; CLINDAMYCIN; GATIFLOXACIN; LEVOFLOXACIN; MOXIFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL OVERGROWTH; COLONY FORMING UNIT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MEGADOSE; ENTEROCOCCUS FAECIUM; INTESTINE FLORA; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ANTI-INFECTIVE AGENTS; BASE SEQUENCE; BETA-LACTAMASES; COLONY COUNT, MICROBIAL; DIGESTIVE SYSTEM; DNA PRIMERS; ENTEROCOCCUS FAECIUM; FLUOROQUINOLONES; INFUSIONS, PARENTERAL; MICE; MOLECULAR SEQUENCE DATA; PHYLOGENY; VANCOMYCIN RESISTANCE;

EID: 0346731289     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.1.326-328.2004     Document Type: Article

References (18)

1. Appelbaum, P. C. 1999. Quinolone activity against anaerobes. Drugs 58(Suppl. 2):60-64.
2. Bergan, T., C. Delin, S. Johansen, I. M. Kolstad, C. E. Nord, and S. B. Thorsteinsson. 1986. Pharmacokinetics of ciprofloxacin and effect of repeated dosage on salivary and fecal microflora. Antimicrob. Agents Chemother. 29:298-302.
3. Brumfitt, W., I. Franklin, D. Grady, J. M. T. Hamilton-Miller, and A. Iliffe. 1984. Changes in the pharmacokinetics of ciprofloxacin and fecal flora during administration of a 7-day course to human volunteers. Antimicrob. Agents Chemother. 26:757-761.
4. Donskey, C. J., J. A. Hanrahan, R. A. Hutton, and L. B. Rice. 1999. Effect of parenteral antibiotic administration on persistence of vancomycin-resistant Enterococcus faecium in the mouse gastrointestinal tract. J. Infect. Dis. 180:384-390.
5. Donskey, C. J., T. K. Chowdhry, M. T. Hecker, C. K. Hoyen, J. A. Hanrahan, A. M. Hujer, R. A. Hutton-Thomas, C. C. Whalen, R. A. Bonomo, and L. B. Rice. 2000. Effect of antibiotic therapy on the density of vancomycin-resistant enterococci in the stool of colonized patients. N. Engl. J. Med. 343:1925-1932.
6. Edlund, C., and C. E. Nord. 1999. Effect of quinolones on intestinal ecology. Drugs 58(Suppl. 2):65-70.
7. Edlund, C., S. Sjostedt, and C. E. Nord. 1997. Comparative effect of levofloxacin and ofloxacin on the normal oral and intestinal microflora. Scand. J. Infect. Dis. 29:383-386.
8. Edlund, C., and C. E. Nord. 1999. Ecological effect of gatifloxacin on the normal human intestinal microflora. J. Chemother. 11:50-53.
9. Edlund, C., G. Beyer, M. Hiemer-Bau, S. Ziege, H. Lode, and C. E. Nord. 2000. Comparative effects of moxifloxacin and clarithromycin on the normal intestinal flora. Scand. J. Infect. Dis. 32:81-85.
10. Edlund, C., L. Lindqvist, and C. E. Nord. 1988. Norfloxacin binds to human fecal material. Antimicrob. Agents Chemother. 32:1869-1874.
11. Freireich, E., E. Gehan, D. Rall, L. Schmidt, and H. Skipper. 1966. Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey and man. Cancer Chemother. Rep. 50:219-244.
12. Hooper D. C. 1995. Quinolones, p. 364-376. In G. L. Mandell, J. E. Bennett, and R. Dolin (ed.), Principles and practice of infectious diseases, 4th ed. Churchill Livingstone, New York, N.Y.
13. Horn, R., and H. G. Robson. 2001. Susceptibility of the Bacteroides fragilis group to newer quinolones and other standard anti-anaerobic agents. J. Antimicrob. Chemother. 48:127-130.
14. Krueger, W. A., G. Ruckdeschel, and K. Unertl. 1997. Influence of intravenously administered ciprofloxacin on aerobic intestinal microflora and fecal drug levels when administered simultaneously with sucralfate. Antimicrob. Agents Chemother. 41:1725-1730.
15. Nord, C. E., D. A. Gajjar, and D. M. Grasela. 2002. Ecological impact of the des-F(6)-quinolone, BMS-284756, on the normal intestinal microflora. Clin. Microbiol. Infect. 8:229-239.
16. Ramon, J., M. Ben-Haim, M. Shabtai, and E. Rubenstein. 2001. Transepithelial intestinal excretion of ciprofloxacin in humans. Clin. Infect. Dis. 32:822-823.
17. van Saene, J. J. M., H. K. F. van Saene, and C. F. Lerk. 1986. Inactivation of quinolone by feces. J. Infect. Dis. 153:999-1000.
18. Vollaard, E. J., and H. A. L. Clasener. 1994. Colonization resistance. Antimicrob. Agents Chemother. 38:409-414.