Triaryl methane derivatives as antiproliferative agents

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 2, 2004, Pages 347-350

  Al Qawasmeh, Raed A ^a   Lee, Yoon ^a   Cao, Ming Yu ^a   Gu, Xiaoping ^a   Vassilakos, Aikaterini ^a   Wright, Jim A ^a   Young, Aiping ^a  

^a Lorus Therapeutics Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; CLOTRIMAZOLE; ECONAZOLE; IMIDAZOLE DERIVATIVE; METRONIDAZOLE; MICONAZOLE;

ANGIOGENESIS; ARTICLE; CARCINOMA CELL; CELL CYCLE; CELL CYCLE S PHASE; CELL GROWTH; CELL PROLIFERATION; DOSE RESPONSE; DRUG EFFICACY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LIVER TOXICITY; LUNG NON SMALL CELL CANCER; STRUCTURE ANALYSIS; TUMOR CELL;

EID: 0346729887     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.11.004     Document Type: Article

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17. All compounds synthesized in this study gave satisfactory physical and spectroscopic analytical results. A general method of synthesis is represented by the synthesis of the triphenyl methanol. A mixture of substituted benzoyl chloride (1 equiv), substituted benzene (1 equiv) and aluminum chloride (1.1 equiv) were stirred at room temperature in methylene chloride. The resulting benzophenone product after purification was reacted with phenylmagnesium bromide and the resultant product was purified and used for the study. General references are: (a) Austin, P.; Johnson, J. J. Am. Chem. Soc. 1932, 54, 647. (b) Rodriguez, G.; Bazen, G. J. Am. Chem. Soc. 1997, 119, 343. (c) Houben, J. Chem. Ber. 1903, 36, 3087. (d) Morton, A., Stevens, J. J. Am. Chem. Soc. 1931, 53, 4028.
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