Barium Chromate Is Cytotoxic and Genotoxic to Human Lung Cells

Environmental and Molecular Mutagenesis

Volumn 42, Issue 4, 2003, Pages 274-278

  Wise, Sandra S ^a   Schuler, Julie H C ^a,b   Katsifis, Spiros P ^b   Wise Sr , John Pierce ^a  

^a UNIVERSITY OF SOUTHERN MAINE   (United States)

^b UNIVERSITY OF BRIDGEPORT   (United States)

Author keywords

Cell culture, bronchial; Chromate, barium chromate; Chromium; Chromosomal aberrations; Cytotoxicity; Genotoxicity

Indexed keywords

BARIUM CHROMATE; BARIUM DERIVATIVE; CARCINOGEN; LEAD CHROMATE; SODIUM CHROMATE; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CELL SURVIVAL; CHROMOSOME ABERRATION; CHROMOSOME DAMAGE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; EXPOSURE; GENE INACTIVATION; GENOTOXICITY; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL; LUNG CANCER; METAPHASE; ONCOGENE; TARGET CELL; TUMOR SUPPRESSOR GENE;

BARIUM; BARIUM COMPOUNDS; CELL CYCLE; CELL LINE; CHROMATES; CHROMIUM; CHROMOSOME ABERRATIONS; CHROMOSOMES; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; HUMANS; LUNG; METAPHASE; TIME FACTORS;

EID: 0346728788     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/em.10203     Document Type: Article

References (16)

1. Abbracchio MP, Heck JD, Costa M. 1982. The phagocytosis and transforming activity of crystalline metal sulfide particles are related to their negative surface charge. Carcinogenesis 3:175-180.
2. Cavanee WK, Dryja TP, Phillips RA, Benedict WF, Godbout R, Gallie BL, Murphee AL, Strong LC, White RL. 1983. Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature 305:779-784.
3. Elias Z, Poirot O, Pezerat H, Suquet H, Schneider O, Daniere MC, Terzetti F, Baruthio F, Fournier M, Cavelier C. 1989. Cytotoxic and neoplastic transforming effects of industrial hexavalent chromium pigments in Syrian hamster embryo cells. Carcinogenesis 10:2043-2052.
4. IARC. 1990. Monographs on the evaluation of carcinogenic risks to humans: chromium, nickel and welding. Vol. 49. Lyons, France: IARC.
5. Ishikawa Y, Nakagawa K, Satoh Y, Kitagawa T, Sugano H, Hirano T, Tsuchiya E. 1994a. Characteristics of chromate workers' cancers, chromium lung deposition and precancerous bronchial lesions: an autopsy study. Br J Cancer 70:160-166.
6. Ishikawa Y, Nakagawa K, Satoh Y, Kitagawa T, Sugano H, Hirano T, Tsuchiya E. 1994b. "Hot spots" of chromium accumulation at bifurcations of chromate workers' bronchi. Cancer Res 54:2342-2346.
7. Klein CB, Su L, Bowser D, Leszcynska J. 2002. Chromate-induced epimutations in mammalian cells. Environ Health Pespect 101(Suppl 5):739-743.
8. Léonard A, Lauwerys RR. 1980. Carcinogenicity and mutagenicity of chromium. Mutat Res 76:277-239.
9. Levy LS, Vanitt S. 1986. Carcinogenicity and mutagenicity of chromium compounds: the association between bronchial metaplasia and neoplasia. Carcinogenesis 7:831-835.
10. Patierno SR, Banh D, Landolph, JR. 1988. Transformation of C3H/10T1/2 mouse embryo cells by insoluble lead chromate but not soluble calcium chromate: relationship to mutagenesis and internalization of lead chromate particles. Cancer Res 47:3815-3823.
11. Singh J, Pritchard DE, Carlisle DL, Mclean JA, Montaser A, Orenstein JM, Patierno SR. 1999. Internalization of carcinogenic lead chromate particles by cultured normal human lung epithelial cells: formation of intracellular lead-inclusion bodies and induction of apoptosis. Toxicol Appl Pharmacol 161:240-248.
12. Venier P, Montaldi A, Gava C, Zentilin L, Tecchio G, Bianchi S, Paglialunga S, Levis AG. 1985. Effects of nitrilotriacetic acid on the induction of gene mutations and sister-chromatid exchanges by insoluble chromium compounds. Mutat Res 156:219-228.
13. Wise JP Sr, Orenstein JM, Patierno SR. 1993. Inhibition of lead chromate clastogenesis by ascorbate: relationship to particle dissolution and uptake. Carcinogenesis 14:429-434.
14. Wise JP Sr, Wise SS, Little JE. 2002. The cytotoxicity and genotoxicity of particulate and soluble hexavalent chromium in human lung cells. Mutat Res 517:221-229.
15. Wise SS, Elmore LW, Holt SE, Little JE, Bryant BH, Wise JP Sr. 2004. Telomerase-mediated lifespan extension of human bronchial cells does not affect hexavalent chromium-induced cytotoxicity or genotoxicity. Mol Cell Biochem 255:103-112.
16. Yunis JJ. 1983. The chromosomal basis for human neoplasia. Science 221:227-236.