Genetics of Human Hypertension

Herz

Volumn 28, Issue 8, 2003, Pages 655-662

  Ruppert, Volker ^a   Maisch, Bernhard ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Blood pressure; Genetics; Hypertension; Polymorphism

Indexed keywords

GLUCOCORTICOID; MINERALOCORTICOID;

AGE; DEMOGRAPHY; ENVIRONMENTAL FACTOR; ESSENTIAL HYPERTENSION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HEREDITY; HUMAN; HYPERALDOSTERONISM; HYPERTENSION; INHERITANCE; LIDDLE SYNDROME; NEUROENDOCRINE DISEASE; PHENOTYPE; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; RISK FACTOR; SCREENING;

CHROMOSOME MAPPING; DNA MUTATIONAL ANALYSIS; GENETICS, POPULATION; GENOTYPE; HUMANS; HYPERTENSION; PHENOTYPE; POLYMORPHISM, GENETIC;

EID: 0346727120     PISSN: 03409937     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00059-003-2516-6     Document Type: Review

References (49)

1. ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs. diuretic: the Hypertensive and Lipid-Lowering Treatment to Prevent Heart Attack (ALLHAT) trial. JAMA 2002;288:2981-97.
2. American Heart Association. 1999 heart and stroke statistical update. Dallas: American Heart Association, 1999.
3. Bähr V, Oelkers W, Diederich S. Monogenetische Hypertonien. Med Klin 2003;98:208-17.
4. Beige J, Hohenbleicher H, Distler A, et al. G-protein beta 3 subunit C825T variant and ambulatory blood pressure in essential hypertension. Hypertension 1999;33:1049-51.
5. Bianchi G, Tripodi G, Casari G, et al. Two point mutations within the adducin genes are involved in blood pressure variation. Proc Natl Acad Sci U S A 1994;91:3999-4003.
6. Brand E, Chatelain N, Mulatero P, et al. Structural analysis and evaluation of the aldosterone synthase gene in hypertension. Hypertension 1998;33:844-9.
7. Chalmers J, MacMahon S, Mancia G, et al. 1999 World Health Organization-International Society of Hypertension guidelines for the management of hypertension. Guidelines Sub-committee of the World Health Organization. Clin Exp Hypertens 1999;21:1009-60.
8. Corvol P, Persu A, Gimenez-Roqueplo AP, et al. Seven lessons from two candidate genes in human essential hypertension: angiotensinogen and epithelial sodium channel. Hypertension 1999;33:1324-31.
9. Cusi D, Barlassina C, Azzani T, et al. Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension. Lancet 1997;349:1353-7.
10. Doris PA. Hypertension genetics, single nucleotide polymorphisms, and the common disease:common variant hypothesis. Hypertension 2002;39:323-31.
11. Fardella C, Zamorano P, Mosso L, et al. A-6G variant of angiotensinogen gene and aldosterone levels in hypertensives. Hypertension 1999;34:779-81.
12. Fornage M, Amos CI, Kardia S, et al. Variation in the region of the angiotensin-converting enzyme gene influences interindividual differences in blood pressure levels in young white males. Circulation 1998;97:1773-9.
13. Geller DS, Farhi A, Pinkerton N, et al. Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy. Science 2000;289:119-23.
14. Hamet P, Pausova Z, Adarichev V, et al. Hypertension: genes and environment. J Hypertens 1998;16:397-418.
15. Hansson JH, Nelson-Williams C, Suzuki H, et al. Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome. Nat Genet 1995;11:76-82.
16. Higaki J, Baba S, Katsuya T, et al. Deletion allele of angiotensin-converting enzyme gene increases risk of essential hypertension in Japanese men: the Suita Study. Circulation 2000;101:2060-5.
17. Inoue I, Nakajima T, Williams CS, et al. A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro. J Clin Invest 1997;99:1786-97.
18. Jeunemaitre X, Soubrier F, Kotelevtsev YV, et al. Molecular basis of human hypertension: role of angiotensinogen. Cell 1992;71:169-80.
19. Julier C, Delepine M, Keavney B, et al. Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome. Hum Mol Genet 1997;6:2077-85.
20. Kato N. Genetic analysis in human hypertension. Hypertens Res 2002;25:319-27.
21. Kato N, Sugiyama T, Morita H, et al. G protein beta 3 subunit variant and essential hypertension in Japanese. Hypertension 1998;32:935-8.
22. Krushkal J, Ferrell R, Mockrin SC, et al. Genome-wide linkage analyses of systolic blood pressure using highly discordant siblings. Circulation 1999;99:1407-10.
23. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 1995;11:241-9.
24. Levy D, DeStefano AL, Larson MG, et al. Evidence a gene influencing blood pressure on chromosome 17: genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the Framingham Heart Study. Hypertension 2000;36:477-83.
25. Lifton RP. Molecular genetics of human blood pressure variation. Science 1996;273:676-80.
26. Lifton RP, Dluhy RG, Powers M, et al. A chimaeric 11 beta-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Nature 1992;355:262-5.
27. Lifton RP, Gharavi AG, Geller DS. Molecular mechanisms of human hypertension. Cell 2001;104:545-56.
28. Luft FC, Miller JZ, Grim CE, et al. Salt sensitivity and resistance of blood pressure: age and race as factors in physiological responses. Hypertension 1991;17:Suppl I:I102-8.
29. Mansfield TA, Simon DB, Farfel Z, et al. Multilocus linkage of familial hyperkalaemia and hypertension, pseudohypoaldosteronism type II, to chromosomes 1q31-42 and 17p11-q21. Nat Genet 1997;16:202-5.
30. Mune T, Rogerson FM, Nikkila H, et al. Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase. Nat Genet 1995;10:394-9.
31. Nabel EG. Cardiovascular disease. N Engl J Med 2003;349:60-72.
32. O'Donnel CJ, Lindpaintner K, Larson MG, et al. Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation 1998;97:1766-72.
33. Pankow JS, Rose KM, Oberman A, et al. Possible locus on chromosome 18q influencing postural systolic blood pressure changes. Hypertension 2000;36:471-6.
34. Perola M, Kainulainen K, Pajulanta P, et al. Genome-wide scan of predisposing loci for increased diastolic blood pressure in Finnish siblings. J Hypertens 2000;18:1579-85.
35. Rice T, Rankinen T, Province MA, et al. Genome-wide linkage analysis of systolic and diastolic blood pressure: the Quebec family study. Circulation 2000;102:1956-63.
36. Rieder MJ, Taylor SL, Clark AG, et al. Sequence variation in the human angiotensin converting enzyme. Nat Genet 1999;22:59-62.
37. Rigat B, Hubert C, Alhenc-Gelas F, et al. An insertion/deletion polymorphism in the angiotensin 1-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990;86:1343-6.
38. 3 subunit gene and lower renin and elevated diastolic blood pressure levels. Hypertension 1998;32:510-3.
39. Sharma P, Fatibene J, Ferraro F, et al. A genome-wide search for susceptibility loci to human essential hypertension. Hypertension 2000;35:1291-6.
40. Shimkets RA, Warnock DG, Bositis CM, et al. Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell 1994;79:407-14.
41. Shuster H, Wienker TF, Bahring S, et al. Severe autosomal dominant hypertension and brachydactyly in a unique Turkish kindred maps to human chromosome 12. Nat Genet 1996;13:98-100.
42. Siffert W, Rosskopf D, Siffert G, et al. Association of a human G-protein β subunit variant with hypertension. Nat Genet 1998;18:45-8.
43. Spielman RS, Ewens WJ. The TDT and other family-based tests for linkage disequilibrium and association. Am J Hum Genet 1996;59:983-9.
44. Staessen JA, Wang JG, Bianchi G, et al. Essential hypertension. Lancet 2003;361:1629-41.
45. Staessen JA, Wang JG, Ginocchio G, et al. The deletion/insertion polymorphism of the angiotensin converting enzyme gene and cardiovascular-renal risk. J Hypertens 1997;15:1579-92.
46. Stoll M, Kwitek-Black AE, Cowley AW Jr, et al. New target regions for human hypertension via comparative genomics. Genome Res 2000;10:473-82.
47. Tiret L, Rigat B, Visvikis S, et al. Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels, Am J Hum Genet 1992;51:197-205.
48. Turner ST, Boerwinkle E. Genetics of blood pressure, hypertensive complications, and antihypertensive drug responses. Pharmacogenomics 2003;4:53-65.
49. Wu DA, Bu X, Warden CH, et al. Quantitative trait locus mapping of human blood pressure to a genetic region at or near the lipoprotein lipase gene locus on chromosome 8p22. J Clin Invest 1996;97:2111-8.