Bcl-2, Bcl-6 and CD10 expression in cutaneous B-cell lymphoma: Further support for a follicle centre cell origin and differential diagnostic significance

British Journal of Dermatology

Volumn 149, Issue 6, 2003, Pages 1183-1191

  Hoefnagel, J J ^a   Vermeer, M H ^a   Jansen, P M ^a   Fleuren, G J ^a   Meijer, C J L M ^b   Willemze, R ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Bcl 2; Bcl 6; CD10; Cutaneous B cell lymphoma; Differential diagnosis

Indexed keywords

COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; DNA BINDING PROTEIN; MEMBRANE METALLOENDOPEPTIDASE; ONCOPROTEIN; PROTEIN BCL 2; PROTEIN BCL 6; PROTO ONCOGENE PROTEIN BCL 6; PROTO-ONCOGENE PROTEIN BCL-6; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; B CELL LYMPHOMA; CHEMISTRY; CUTANEOUS PSEUDO B CELL LYMPHOMA; DIFFERENTIAL DIAGNOSIS; FOLLICULAR LYMPHOMA; HUMAN; HUMAN TISSUE; IMMUNOCYTOMA; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; LARGE CELL LYMPHOMA; LEG; LYMPH NODE; LYMPHOPROLIFERATIVE DISEASE; METABOLISM; METHODOLOGY; NODAL FOLLICULAR LYMPHOMA; PATHOLOGY; PRIMARY CUTANEOUS FOLLICLE CENTER CELL LYMPHOMA; PRIMARY CUTANEOUS LARGE B CELL LYMPHOMA OF THE LEG; PRIMARY CUTANEOUS MARGINAL ZONE B CELL LYMPHOMA; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PSEUDOLYMPHOMA; SECONDARY CUTANEOUS FOLLICULAR LYMPHOMA; SKIN BIOPSY; SKIN LYMPHOMA; SKIN TUMOR; TUMOR CELL;

DIAGNOSIS, DIFFERENTIAL; DNA-BINDING PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; LEG; LYMPHOMA, B-CELL; LYMPHOMA, FOLLICULAR; LYMPHOMA, LARGE-CELL, DIFFUSE; NEPRILYSIN; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-BCL-6; PSEUDOLYMPHOMA; SKIN NEOPLASMS; TRANSCRIPTION FACTORS;

EID: 0346725893     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2003.05649.x     Document Type: Article

References (38)

1. Willemze R, Kerl H, Sterry W et al. EORTC classification for primary cutaneous lymphoma: a proposal from the Cutaneous Lymphoma Study Group of the European Organization for Research and Treatment of Cancer. Blood 1997; 90: 354-71.
2. Stansfeld AG, Diebold J, Noel H et al. Updated Kiel classification for lymphomas. Lancet 1988; i: 292-3.
3. Garcia CF, Weiss LM, Warnke RA et al. Cutaneous follicular lymphoma. Am J Surg Pathol 1986; 10: 454-63.
4. Willemze R, Meijer CM, Sentis HJ et al. Primary cutaneous large cell lymphomas of follicular center cell origin. J Am Acad Dermatol 1987; 16: 518-26.
5. Berti E, Alessi E, Caputo R et al. Reticulohistiocytoma of the dorsum. J Am Acad Dermatol 1988; 19: 259-72.
6. Santucci M, Pimpinelli N, Arganini L. Primary cutaneous B-cell lymphoma: a unique type of low-grade lymphoma. Cancer 1991; 67: 2311-26.
7. Jaffe ES, Harris NL. Stein H et al. World Health Organisation Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC Press, 2001.
8. Cerroni L, Volkenandt M, Rieger F, et al. Bcl-2 protein expression and correlation with the interchromosomal (14:18) translocation in cutaneous lymphomas and pseudolymphomas. J Invest Dermatol 1994; 102: 231-5.
9. Delia D, Borrello MG, Berti E et al. Clonal immunoglobulin rearrangements and normal T-cell receptor, bcl-2 and c-myc in primary cutaneous B-cell lymphomas. Cancer Res 1989; 49: 4901-5.
10. Geelen FAMJ, Vermeer MH, Meijer CJLM et al. Bcl-2 expression in primary cutaneous large B-cell lymphoma is site-related. J Clin Oncol 1998; 16: 2080-5.
11. Cerroni L, Arzberger E, Pütz B et al. Primary cutaneous follicular center cell lymphoma with follicular growth pattern. Blood 2000; 95: 3922-8.
12. Child FJ, Russell-Jones R, Woolford AJ et al. Absence of the t(14;18) chromosomal translocation in primary cutaneous B-cell lymphoma. Br J Dermatol 2001; 144: 735-44.
13. Slater DN. MALT and SALT: the clue to cutaneous B-cell lymphoproliferative disease. Br J Dermatol 1994; 131: 557-61.
14. Goodlad JR, Krajewski AS, Batstone PJ et al. Primary cutaneous follicular lymphoma. A clinicopathologic and molecular study of 16 cases in support of a distinct entity. Am J Surg Pathol 2002; 26: 733-41.
15. Franco R, Fernández-Vázquez A, Rodríguez-Peralto JL et al. Cutaneous follicular B-cell lymphoma: description of a series of 18 cases. Am J Surg Pathol 2001; 25: 875-83.
16. Yang B, Tubbs RR, Finn W et al. Clinicopathologic reassessment of primary cutaneous B-cell lymphomas with immunophenotypic and molecular genetic characterization. Am J Surg Pathol 2000; 24: 694-702.
17. Gronbaek K, Moller PH, Nedergaard T et al. Primary cutaneous B-cell lymphoma: a clinical, histological, phenotypic and genotypic study of 21 cases. Br J Dermatol 2000; 142: 913-23.
18. de Leval L, Harris NL, Longtine J et al. Cutaneous B-cell lymphomas of follicular and marginal zone types. Use of Bcl-6, CD10, Bcl-2, and CD21 in differential diagnosis and classification. Am J Surg Pathol 2001; 25: 732-41.
19. Mirza I, Macpherson S, Paproski S et al. Primary cutaneous follicular lymphoma: an assessment of clinical, histopathologic, immunophenotypic, and molecular features. J Clin Oncol 2002; 20: 647-55.
20. Aguilera NSI, Tomaszewski MM, Moad JC et al. Cutaneous follicle center lymphoma: a clinicopathologic study of 19 cases. Mod Pathol 2001; 14: 828-35.
21. Bergman R, Kurtin PJ, Gibson LE et al. Clinicopathologic, immunophenotypic, and molecular characterization of primary cutaneous follicular B-cell lymphoma. Arch Dermatol 2001; 137: 432-9.
22. Lawnicki LC, Aoun P, Chan WC et al. The t(14;18) and bcl-2 expression are present in a subset of primary cutaneous follicular lymphomas (PCFCL). Mod Pathol 2001; 14: 170A.
23. Fernández-Vásquez A, Rodríguez-Peralto JL, Martínez MA et al. Primary cutaneous large B-cell lymphoma. The relation between morphology, clinical presentation, immunohistochemical markers, and survival. Am J Surg Pathol 2001; 25: 307-15.
24. Uherova P, Ross CW, Schnitzer B et al. The clinical significance of CD10 antigen expression in diffuse large B-cell lymphoma. Am J Clin Pathol 2001; 115: 582-8.
25. Lossos IS, Jones CD, Warnke R et al. Expression of a single gene, BCL-6, strongly predicts survival in patients with diffuse large B-cell lymphoma. Blood 2001; 98: 945-51.
26. Willemze R, Meijer CJLM, Scheffer E et al. Diffuse large cell lymphomas of follicular center cell origin presenting in the skin. A histopathological and immunologic study of 16 cases. Am J Pathol 1987; 126: 325-33.
27. Aarts WM, Willemze R, Bende RJ et al. VH gene analysis of primary cutaneous B-cell lymphomas: evidence for ongoing somatic hypermutation and isotype switching. Blood 1998; 92: 3857-64.
28. Gellrich S, Rutz S, Golembowski S et al. Primary cutaneous follicle center cell lymphomas and large B-cell lymphomas of the leg descend from germinal center cells. A single cell polymerase chain reaction analysis. J Invest Dermatol 2001; 117: 1512-20.
29. Rijlaarsdam JU, van der Putte SCJ, Berti E et al. Cutaneous immunocytomas: a clinicopathologic study of 26 cases. Histopathology 1993; 23: 119-25.
30. Vermeer MH, van Geelen FAMJ, Haselen CW et al. Primary cutaneous large B-cell lymphomas of the legs. A distinct type of cutaneous B-cell lymphoma with an intermediate prognosis. Arch Dermatol 1996; 132: 1304-8.
31. Grange F, Bekkenk MW, Wechsler J et al. Prognostic factors in primary cutaneous large B-cell lymphomas: a European multi-center study. J Clin Oncol 2001; 19: 3602-10.
32. Hallerman C, Kaune K, Siebert R et al. Cytogenetic aberration patterns differ in subtypes of primary cutaneous B-cell lymphomas. J Invest Dermatol, in press.
33. Hermine O, Haioun C, Lepage E et al. Prognostic significance of bcl-2 protein expression in aggressive non-Hodgkin's lymphoma. Groupe d'Étude des Lymphomes de l'Adulte (GELA). Blood 1996; 87: 265-72.
34. Kramer MH, Hermans J, Parker J et al. Clinical significance of bcl-2 and p53 protein expression in diffuse large B-cell lymphoma: a population-based study. J Clin Oncol 1996; 14: 2131-8.
35. Hill ME, MacLennan KA, Cunningham DC et al. Prognostic significance of BCL-2 expression and bcl-2 major breakpoint region rearrangement in diffuse large cell non-Hodgkin's lymphoma: a British National Lymphoma Investigation Study. Blood 1996; 88: 1046-51.
36. Gascoyne RD, Adomat SA, Krajewski S et al. Prognostic significance of Bcl-2 protein expression and Bcl-2 gene rearrangement in diffuse aggressive non-Hodgkin's lymphoma. Blood 1997; 90: 244-51.
37. Russell-Jones R. World Health Organization classification of hematopoietic and lymphoid tissues: implications for dermatology. J Am Acad Dermatol 2003; 48: 93-102.
38. Hsi E, Mirza I, Gascoyne RD. Absence of t(14;18) chromosomal translocation in primary cutaneous B-cell lymphoma. Br J Dermatol 2002; 146: 1110-11.