Raman Spectroscopic Monitoring and Control of Aprotinin Supersaturation in Hanging-Drop Crystallization

Crystal Growth and Design

Volumn 2, Issue 4, 2002, Pages 263-267

  Tamagawa, Rosana E ^a   Miranda, Everson A ^a   Berglund, Kris A ^b,c  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c LULEÅ UNIVERSITY OF TECHNOLOGY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0346677856     PISSN: 15287483     EISSN: None     Source Type: Journal    
DOI: 10.1021/cg025524k     Document Type: Article

References (7)

1. Hamiaux, C.; Pérez, J.; Prangé, T.; Veesler, S.; Riès-Kautt; Vachette, P. The BPTI decamer observed in acidic pH crystal forms preexists as a stable species in solution. J. Mol. Biol. 2000, 297, 697-712.
2. Lafont, S.; Veesler, S.; Astier, J. P.; Boistelle, R. Comparison of solubilities and molecular interactions of BPTI molecules giving different polymorphs. J. Cryst. Growth 1997, 173, 132-140.
3. Lafont, S.; Veesler, S.; Astier, J. P.; Boistelle, R. Solubility and prenucleation of aprotinin (BPTI) molecules in sodium chloride solutions. J. Cryst. Growth 1994, 143, 249-255.
4. Schwartz, A.; Berglund, K. A. The use of Raman spectroscopy for in situ monitoring of lysozyme concentration during crystallization in a hanging drop. J. Cryst. Growth 1999, 203, 599-603.
5. Veesler, S.; Lafont, S.; Marrcq, S.; Astier, J. P.; Boistelle, R. Prenucleation, crystal growth and polymorphism of some proteins. J. Cryst. Growth 1996, 168, 124-129.
6. Walter, J.; Huber, R. Pancreatic trypsin inhibitor, a new crystal form and its analysis. J. Mol. Biol. 1983, 167, 911-917.
7. Wlodawer, A.; Nachman, J.; Gilliland, G. L.; Gallagher, W.; Woodward, C. Structure of form III crystals of bovine pancreatic trypsin inhibitor. J. Mol. Biol. 1987, 198, 469-480.