Environmental polychlorinated biphenyl exposure and cytochromes P450 in raccoons (Procyon lotor)

Environmental Toxicology and Chemistry

Volumn 22, Issue 2, 2003, Pages 417-423

  Smith, Philip N ^a   Bandiera, Stelvio M ^b   Skipper, Sherry L ^c   Johnson, Kevin A ^d   McMurry, Scott T ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c US Fish and Wildlife Service   (United States)

^d SOUTHERN ILLINOIS UNIVERSITY EDWARDSVILLE   (United States)

Author keywords

Biomarker; Cytochrome P450; Paducah; Polychlorinated biphenyls; Raccoon

Indexed keywords

BIOMARKERS; CONCENTRATION (PROCESS); PROTEINS;

RACCOONS;

POLYCHLORINATED BIPHENYLS;

BIOLOGICAL MARKER; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; PENTOXYRESORUFIN DEALKYLASE; POLYCHLORINATED BIPHENYL;

BIOMARKER; CARNIVORE; CYTOCHROME; PCB; PHYSIOLOGICAL RESPONSE; POLLUTION EXPOSURE;

ADIPOSE TISSUE; AIR POLLUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; FEMALE; GAS DIFFUSION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; RACCOON; REGRESSION ANALYSIS; UNITED STATES; WILDLIFE CONSERVATION;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; ENZYME INDUCTION; KENTUCKY; METALLURGY; MICROSOMES, LIVER; POLYCHLORINATED BIPHENYLS; RACCOONS;

ANIMALIA; PROCYON; PROCYON LOTOR; VERTEBRATA;

EID: 0346665813     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1897/1551-5028(2003)022<0417:EPBEAC>2.0.CO;2     Document Type: Article

References (26)

1. Bandiera SM, Torok SM, Letcher RJ, Norstrom RJ. 1997. Immunoquantitation of cytochromes P450 1A and P450 2B and comparison with chlorinated hydrocarbon levels in archived polar bear liver samples. Chemosphere 34:1469-1479.
2. Bandiera SM, Torok SM, Lin S, Ramsay MA, Norstrom RJ. 1995. Catalytic and immunologic characterization of hepatic and lung cytochromes P450 in the polar bear. Biochem Pharm 49:1135-1146.
3. Letcher RJ, Norstrom RJ, Lin S, Ramsay MA, Bandiera SM. 1996. Immunoquantitation and microsomal monooxygenase activities of hepatic cytochromes P4501A and P4502B and chlorinated hydrocarbon contaminant levels in polar bear (Ursus maritimus). Toxicol Appl Pharm 137:127-140.
4. Lochmiller RL, McMurry ST, McBee K, Rafferty DP, Lish JW, Qualls CW Jr. 1999. Seasonal hepatic cytochrome P-450 induction in cotton rats (Sigmodon hispidus) inhabiting petrochemical waste sites. Environ Pollut 105:191-196.
5. Norstrom RJ, Belikov SE, Born EW, Garner GW, Malone B, Olpinski S, Ramsay MA, Schliebe S, Stirling I, Stishov MS, Taylor MK, Wiig O. 1998. Chlorinated hydrocarbon contaminants in polar bears from eastern Russia, North America, Greenland, and Svalbard: Biomonitoring of Arctic pollution. Arch Environ Contam Toxicol 35:354-367.
6. Rattner BA, Hoffman DJ, Marn CM. 1989. Use of mixed-function oxidases to monitor contaminant exposure in wildlife. Environ Toxicol Chem 8:1093-1102.
7. Stegman JJ, Brouwer M, Di Giulio RT, Forlin L, Fowler BA, Sanders BM, Van Veld PA. 1992. Molecular responses to environmental contamination: Enzyme and protein systems as indicators of chemical exposure and effect. In Hugget RJ, Kimerle RA, Mehrle PM Jr, Bergman HL, eds, Biomarkers: Biochemical, Physiological, and Histological Markers of Anthropogenic Stress. Lewis, Boca Raton, FL, USA, pp 235-236.
8. Yawetz A, Benedek-Segal M, Woodin B. 1997. Cytochrome P4501A immunoassay in freshwater turtles and exposure to PCBs and environmental pollutants. Environ Toxicol Chem 16:1802-1806.
9. Aulerich RJ, Ringer RK, Iwamoto S. 1973. Reproductive failure and mortality in mink fed on Great Lakes fish. J Reprod Fertil 19:365-376.
10. Linzey AV. 1987. Effects of chronic polychlorinated biphenyls exposure on reproductive success of white-footed mice (Peromyscus leucopus). Arch Environ Contam Toxicol 16:455-460.
11. Ross P, DeSwart R, Addison R, VanLoveren H, Vos J, Osterhaus A. 1996. Contaminant-induced immunotoxicity in harbour seals: Wildlife at risk? Toxicology 112:157-169.
12. Tryphonas H. 1994. Immunotoxicity of polychlorinated biphenyls: Present status and future considerations. Exp Clin Immunogenet 11:149-162.
13. Tryphonas H. 1995. Immunotoxicity of PCBs (Aroclors) in relation to Great Lakes. Environ Health Perspect 103(Suppl. 9): 35-46.
14. Tryphonas H, Luster MI, Schiffman G, Dawson LL, Hodgen M, Germolec D, Hayward S, Bryce F, Loo JCK, Mandy F, Arnold DL. 1991. Effect of chronic exposure of PCB (Aroclor 1254) on specific and nonspecific immune parameters in the Rhesus (Macaca mulatta) monkey. Fundam Appl Toxicol 16:773-786.
15. Safe S. 1994. Polychlorinated biphenyls (PCBs): Environmental impact, biochemical and toxic responses, and implications for risk assessment. Crit Rev Toxicol 24:87-149.
16. Smith PN, Johnson, KA, Anderson TA, McMurry ST. 2002. Environmental exposure to polychlorinated biphenyls among raccoons (Procyon lotor) at the Paducah Gaseous Diffusion Plant, western Kentucky, USA. Environ Toxicol Chem 22:406-416.
17. Nalley L, Hoff G, Bigler W, Hull W. 1975. Pesticide levels in the omental fat of Florida raccoons. Bull Environ Contam Toxicol 13:741-744.
18. Layher WG, Fox LB, Broxterman R. 1987. Environmental contaminants in raccoons in Kansas. Bull Environ Contam Toxicol 39:926-932.
19. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, Klenk DC. 1985. Measurement of protein using bicichoninic acid. Anal Biochem 150:76-85.
20. Omura T, Sato R. 1964. The carbon monoxide-binding pigment of liver microsomes. J Biol Chem 239:2370-2378.
21. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-275.
22. Neter J, Wasserman W, Kutner MH. 1985. Applied Linear Statistical Models, 2nd ed. Irwin, Homewood, IL, USA.
23. Burke MD, Thompson S, Weaver RJ, Roland-Wolfe C, Mayer RT. 1994. Cytochrome P450 specificities of alkoxyresorufin-O-dealkylase in human and rat liver. Biochem Pharmacol 48:923-936.
24. Lewis DFV, Ioannides C, Parke DV. 1998. Cytochromes P450 and species differences in xenobiotic metabolism and activation of carcinogen. Environ Health Persect 106:633-641.
25. O'Brien SJ. 1987. The ancestry of the giant panda. Sci Am 257: 102-107.
26. Ngui JS, Bandiera SM. 1999. Induction of hepatic CYP2B is a more sensitive indicator of exposure to Aroclor 1260 than CYP1A in male rats. Toxicol Appl Pharmacol 161:160-170.