5-Hydroxy-L-tryptophan suppresses food intake in food-deprived and stressed rats

Pharmacology Biochemistry and Behavior

Volumn 77, Issue 1, 2004, Pages 137-143

  Amer, Ahmed ^a   Breu, Jeff ^b   McDermott, Janine ^b   Wurtman, Richard J ^b   Maher, Timothy J ^a,b  

^a MA Coll of Pharm and Hlth Sci   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

5 Hydroxy L tryptophan; Carbohydrate; Food intake; Protein; Serotonin

Indexed keywords

5 HYDROXYTRYPTOPHAN; AMINO ACID TRANSPORTER; VALINE;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG TISSUE LEVEL; FEMALE; FOOD DEPRIVATION; FOOD INTAKE; HUMAN; HYPERPHAGIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STRESS; TAIL;

EID: 0346655097     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2003.10.011     Document Type: Article

References (31)

1. Berardino M.B., Roingeard F.C., Fukagawa N.K. Plasma tryptophan and tyrosine concentrations: determination using high performance liquid chromatography and fluorometric detection. J. Nutr. Biochem. 1:1990;220-222.
2. Berry E.M., Growdon J.H., Wurtman J.J., Caballero B., Wurtman R.J. A balanced carbohydrate: protein diet in the management of Parkinson's disease. Neurology. 41:1991;1295-1297.
3. Brzezinski A.A., Wurtman J.J., Wurtman R.J., Gleason R., Greenfield J., Nader T. D-fenfluramine suppresses the increased calorie and carbohydrate intakes and improves the mood of women with premenstrual depression. Obstet. Gynecol. 76(2):1990;296-391.
4. Cangiano C., Ceci F., Cascino A., Del Ben M., Laviano A., Muscaritoli M.et al. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan. Am. J. Clin. Nutr. 56:1992;863-867.
5. Cangiano C., Laviano A., Del Ben M., Preziosa F., Angelico F., Cascino A.et al. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients. Int. J. Obes. Relat. Metab. Dis. 22:1998;648-654.
6. Ceci F., Cairella M., Cascino A., Del Ben M., Muscaritoli M., Sibilia L.et al. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects. J. Neural Transm. 76:1989;109-117.
7. Clark J.M., Clark A.J.M., Winn P. N-methyl-D-aspartate lesions of the lateral hypothalamus do not reduce amphetamine or fenfluramine anorexia but enhance the acquisition of eating in response to tail pinch in the rat. Psychopharmacology. 109:1992;331-337.
8. G-nitro-L- arginine methyl ester reduces stress-related feeding in the rat tail-pinch model. Pharmacol. Biochem. Behav. 60:1998;91-96.
9. Fernstrom J.D., Wurtman R.J. Brain serotonin content: increase following ingestion of carbohydrate diet. Science. 174:1971;1023-1025.
10. Fernstrom J.D., Wurtman R.J. Brain serotonin content: physiological regulation by plasma neutral amino acids. Science. 178:1972;414-416.
11. Fernstrom J.D., Wurtman R.J., Hammarstrom W., Rand W.M., Munro H.N., Davidson C.S. Diurnal variations in plasma concentrations of tryptophan, tyrosine, and other neutral amino acids: effect of dietary protein intake. Am. J. Clin. Nutr. 32:1979;1912-1922.
12. Fletcher P.J., Burton M.J. Dissociation of the anorectic actions of 5-HTP and fenfluramine. Psychopharmacologia. 89:1986;216-220.
13. Glaeser B.S., Maher T.J., Wurtman R.J. Changes in brain levels of acidic, basic, and neutral amino acids after consumption of single meals containing various proportions of protein. J. Neurochem. 41(4):1983;1016-1021.
14. Graeff F.C., Guimares F.C., De Andrade T.G.C.S., Deakin J.F.W. Role of 5-HT in stress, anxiety and depression. Pharmacol. Biochem. Behav. 54:1996;129-141.
15. Halford J.C., Blundell J.E. Pharmacology of appetite suppression. Prog. Drug Res. 54:2000;25-58.
16. Hull M.H., Maher T.J. L-tyrosine potentiates the anorexia induced by mixed acting sympathomimetic drugs in hyperphagic rats. J. Pharmacol. Exp. Ther. 255:1990;403-409.
17. Ju C.Y., Tsai C.T. Serotonergic mechanisms involved in the suppression of feeding by 5-HTP in rats. Chin. J. Physiol. 38:1995;235-240.
18. Maher T.J., Glaeser B.S., Wurtman R.J. Diurnal variations in plasma concentrations in plasma concentrations of basic and neutral amino acids and in red cell concentrations of aspartate and glutamate: effects of dietary protein intake. Am. J. Clin. Nutr. 39:1984;722-729.
19. Maher T.J., Ulus I.H., Wurtman R.J. Phentermine, an unrecognized MAO inhibitor, could increase plasma serotonin when given with serotonin uptake blockers. Lancet. 353:1999;38.
20. Maher T.J., Maurette J.M., Bejot M., Wurtman R.J. The serotonin precursor 5-hydroxy-L-tryptophan decreases food intake in food-deprived and stress-induced rats. FASEB J. 15:2001;A223.
21. Morley J.E., Levine A.S. Stress-induced eating is mediated through endogenous opiates. Science. 209:1980;1259-1261.
22. O'Rourke D., Wurtman J.J., Wurtman R.J., Chebli R., Gleason R. Treatment of seasonal depression with D-fenfluramine. J. Clin. Psychiatry. 50:1989;343-347.
23. Pardridge W.M. Blood-brain barrier carrier-mediated transport and brain metabolism of amino acids. Neurochem. Res. 23:1998;635-644.
24. Robiolio P.A., Rigolin V.H., Wilson J.S. Carcinoid heart disease correlation of high serotonin levels with valvular abnormalities detected by cardiac catheterization and echocardiography. Circulation. 92:1995;790-795.
25. Spring B., Wurtman J., Gleason R., Kessler K., Wurtman R.J. Weight gain and withdrawal symptoms after smoking cessation: a preventive intervention using D-fenfluramine. Health Psychol. 10:1991;216-223.
26. Ulus I.H., Maher T.J., Wurtman R.J. Characterization of phentermine and related compounds as monoamine oxidase inhibitors (MAOI). Biochem. Pharmacol. 59:2000;1611-1621.
27. Van Praag H.M. Management of depression with serotonin precursors. Biol. Psychiatry. 16:1981;291-310.
28. Van Woert M.H., Rosenbaum D. L-5-hydroxytrytophan therapy in myoclonus. Adv. Neurol. 26:1979;107-115.
29. Wurtman J.J., Wurtman R.J. Drugs that enhance central serotoninergic transmission diminish elective carbohydrate consumption by rats. Life Sci. 24:1979;895-904.
30. Wurtman J.J., Wurtman R.J., Reynolds S., Tsay R., Chew B. Fenfluramine suppresses snack intake among carbohydrate cravers but not among noncarbohydrate cravers. Int. J. Eat. Disord. 6:1979;687-699.
31. Wyatt R.J., Vaughan T., Galanter M., Kaplan J., Green R. Behavioral changes of chronic schizophrenic patients given L-5-hydroxytrytophan. Science. 177:1972;1124-1126.