Use of Polymyxin B for Treatment of Endotoxemia in Horses

Compendium on Continuing Education for the Practicing Veterinarian

Volumn 22, Issue 11, 2000, Pages 1056-1059

  Barton, Michelle Henry ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0346534559     PISSN: 01931903     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (10)

1. Morris DD: Endotoxemia in horses: A review of cellular and humoral mediators involved in its pathogenesis. J Vet Intern Med 5:167-181, 1991.
2. Spier SJ, Lavoie JP, Cullor JS, et al: Protection against endotoxemia in horses by using plasma containing antibody to an Rc mutant E. coli (J5). Circ Shock 28: 235-248, 1989.
3. Coyne CP, Fenwick BW: Inhibition of lipopolysaccharide-induced macrophage tumor necrosis factor synthesis by polymyxin B sulfate. Am J Vet Res 54:305-314, 1993.
4. Endo S, Inada K, Kikuchi M, et al: Clinical effects of intramuscular administration of a small dose of polymyxin B to patients with endotoxemia. Res Commun Chem Pathol Pharmacol 83:223-235, 1994.
5. Raisbeck MF, Garner HE, Osweiler GD: Effects of polymyxin B on selected features of equine carbohydrate overload. Vet Hum Toxicol 31:422-426, 1989.
6. Durando M, MacKay R, Linda S, Skelley L: Effects of polymyxin B and Salmonella typhimurium antiserum on horses given endotoxin intravenously. Am J Vet Res 55: 921-927, 1994.
7. Parviainen AK, Barton MH, Norton NN: Evaluation of polymyxin B in an ex vivo model of endotoxemia in horses. Am J Vet Res, in press, 2000.
8. Barton MH, Parviainen AK, Norton NN, Moore JN: Use of polymyxin B for equine endotoxemia. Proc ACVIM Forum, Seattle, WA, May 25-28, 2000.
9. Product information: Polymyxin B. Bedford, OH, Bedford Laboratories, August 1999.
10. MacKay RJ, Clark CK, Lodgeberg L, Lake P: Effect of a conjugate of polymyxin B-dextran 70 in horses with experimentally induced endotoxemia. Am J Vet Res 60:68-75, 1999.