Human corneal stromal tissue concentration after consecutive doses of topically applied 3.3% vancomycin

British Journal of Ophthalmology

Volumn 88, Issue 1, 2004, Pages 22-24

  Cahane, M ^a   Ben Simon, G J ^a   Barequet, I S ^a   Grinbaum, A ^a   Diamanstein Weiss, L ^a   Goller, O ^a   Rubinstein, E ^a   Avni, I ^a  

^a SHEBA MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

EYE DROPS; VANCOMYCIN;

ADULT; AGED; ARTICLE; BACTERIUM CULTURE; BIOASSAY; CLINICAL ARTICLE; CONTROLLED STUDY; CORNEA; CORNEA SCAR; DOSE RESPONSE; DRUG DOSE REGIMEN; DRUG PENETRATION; FEMALE; HUMAN; KERATOCONUS; MALE; PENETRATING KERATOPLASTY; PRIORITY JOURNAL; SCAR; STAPHYLOCOCCUS AUREUS; STROMA CELL;

ADULT; AGED; ANTI-BACTERIAL AGENTS; ANTIBIOTIC PROPHYLAXIS; CORNEAL STROMA; EYE INFECTIONS, BACTERIAL; FEMALE; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; KERATITIS; KERATOPLASTY, PENETRATING; MALE; MIDDLE AGED; OPHTHALMIC SOLUTIONS; SURGICAL WOUND INFECTION; VANCOMYCIN;

EID: 0346494660     PISSN: 00071161     EISSN: None     Source Type: Journal    
DOI: 10.1136/bjo.88.1.22     Document Type: Article

References (14)

1. Phinney RB, Schwartz SD, Lee DA, et al. Collagen-shield delivery of gentamycin and vancomycin. Arch Ophthalmol 1988;106:1599-1604.
2. Callegan MC, Engel LS, Hill JM, et al. Ciprofloxacin versus tobramycin for the treatment of staphylococcal keratitis. Invest Ophthalmol Vis Sci 1994;35:1033-7.
3. McDermott ML, Tran TD, Cowden JW, et al. Corneal stromol penetration of topical ciprofloxacin in humans. Ophthalmology 1993;100:197-200.
4. Schaefer F, Bruttin O, Zografos L, et al. Bacterial keratitis: a prospective clinical and microbiological study. Br J Ophthamol 2001;85:842-7.
5. Goodman DF, Gottsch JD. Methicillin-resistant staphylococcus epidermidis keratitis treated with vancomycin. Arch Ophthalmol 1988;106:1570-1.
6. Gordon YJ. Perspective: Vancomycin prophylaxis and emerging resistance: Are ophthalmologists the villains? The heroes? Am J Ophthalmol 2001;31:371-6.
7. Barza M, Kane A, Baum J. A collagenase digestion method for bioassay of antibiotics in ocular tissues. Am J Ophthalmol 1978;86:121-8.
8. Price FW Jr, Whitson WE, Collins KS, et al. Corneal tissue levels of topically applied ciprofloxacin. Cornea 1995:152-6.
9. Insler MS, Helm CJ, George WJ. Topical vs systemic gentamycin penetration into the human cornea and aqueous humor. Arch Ophthalmol 1987;105:922-4.
10. Watanakunakorn C. The antibacterial action of vancomycin. Rev Infect Dis 1981;3(suppl):S210-S15.
11. Lindquist TD, Roth BP, Fritsche TR. Stability and activity of vancomycin in corneal storage media. Cornea 1993;12:222-7.
12. Smith MA, Sorenson JA, Lowy FD, et al. Treatment of experimental methicillin-resistant staphylococcus epidermidis endophthalmitis with intravitreal vancomycin. Ophthalmology 1986;93:1328-35.
13. Souli M, Kopsinis G, Kavouklis E, et al. Vancomycin levels in human aqueous humour after intravenous and subconjunctival administration. Int J Antimicrob Agents 2001;18:239-43.
14. Huerva V, Sinues B, del Buey MA, et al. Levels of vancomycin in aqueous humor after topical eye drops administration. J Ocul Pharmacol 1993;9:167-70.