Effects of Azadirachta indica extract on gastric ulceration and acid secretion in rats

Journal of Ethnopharmacology

Volumn 90, Issue 1, 2004, Pages 167-170

  Raji, Yinusa ^a   Ogunwande, Isiaka Ajani ^a   Osadebe, Caleb Amaechi ^a   John, Godwin ^a  

^a UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

Acid; Antiulcer; Azadirachta indica; Ulceration

Indexed keywords

ANTIULCER AGENT; CIMETIDINE; HISTAMINE AGONIST; HISTAMINE H2 RECEPTOR; INDOMETACIN; PLANT EXTRACT; PROPRANOLOL;

ACID SECRETION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AZADIRACHTA INDICA; BARK; CELL PROTECTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; HISTAMINE RELEASE; MALE; NONHUMAN; RAT; STOMACH PH; STOMACH ULCER;

EID: 0346492905     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2003.09.020     Document Type: Article

References (21)

1. Bardhan J., Riar S.S., Sawhney R.C., Kain A.K., Thomas P., IIavazhagen G. Neem oil: a fertility controlling agent in Rhesus monkey. Indian Journal of Pharmacology. 35:1991;278-280.
2. Berglindh T. Effects of common inhibitors of gastric acid secretion on secretagogue-induced respiration and aminopyrine accumulation in isolated gastric glands. Biochemical Biophysical Acta. 464:1977;217-233.
3. 2+-dependent secretagogue stimulation in isolated rabbit gastric glands. American Journal of Physiology. 239:1980;G20-G94.
4. 2-receptors. Nature. 236:1972;385-390.
5. Bottcher G., Hakanson G., Nilson R.S., Sundler F. Effect of long-term hypergastrinaemia on the ultrastructure of enterochromafinlike cells in the stomach of the rat, hamster, and guinea pig. Cell Tissue Respiration. 256:1989;247-325.
6. Chew C.S., Hersey S.J., Sachs G., Berglindh T.H. Histamine responsiveness of isolated gastric glands. American Journal of Physiology. 238:1980;G312-G320.
7. Dial E., Thompson J., Rosenfeld G.C. Isolated parietal cells histamine response and pharmacology. Journal of Pharmacology and Experimental Therapeutic. 219:1981;586-590.
8. Ghosh M.N., Schild H.O. Continuous recording of acid gastric secretion in the rat. British Journal of Pharmacology. 21:1958;1393-1396.
9. Iwu, N.M., Obiora, O., Anazodo, M., 1986. Biochemical mechanism of antimalarial activity of Azadirachta indica leaf extract. In: Sofowora, A. (Ed.), Proceedings of a Workshop on State of Medicinal Plant Research in Nigeria. Ife University Press, 1986, p. 369.
10. Kraus W., Cramer R., Sawitzki G. Tetranortriterpenoids from the seeds of Azadirachta indica. Phytochemistry. 20:1981;117-120.
11. Lai K.S. Studies on gastrin. Gut. 5:1964;327-341.
12. Machen, T.E., Forte, J.G., 1979. Gastric secretion. In: Guebischil, G., Tasteson, D.C., Using, H.H. (Eds.), Handbook of Transport Organs. Springer, Berlin, pp. 693-747.
13. Njar V.C.O., Adesanwo J.K., Raji Y. Methyl angolensate: the antiulcer agent of the stem bark of Entandrophragma angolense. Planta Medica. 61:1995;91-92.
14. Nwude, N., 1986. In: Sofowora, A. (Ed.), Veterinary Aspects of Medicinal Plant Research in Nigeria. Ife University Press, 1986, pp. 101-103.
15. Okpaniyi, S.N., Ezeukwu, G.C., 1981. Anti inflammatory and antipyretic activities of Azadirachta indica. Planta Medica 41, 34-39.
16. Oliver-Bever, B., 1986. Medicinal Plants in Tropical West Africa. Cambridge University Press, 1986.
17. Prakash A.O., Tiwari R.K., Mathur R. Non-hormonal postcoital contraceptive action of neem oil in rats. Journal of Ethnopharmacology. 23:1988;3-9.
18. Raji Y., Bolarinwa A.F. Antifertility activity of Quassia amara in male rats: in vivo study. Life Sciences. 61:1997;1067-1074.
19. Sen P., Mediratta P.K., Ra A. Effect of Azadirachta indica (A. Juss) on some biochemical, immunological and visceral parameters in normal and stressed rats. Indian Journal of Experimental Biology. 30:1992;1170-1175.
20. Thompson E.B., Anderson C.C. Cardiovascular effect of Azadirachta indica extract. Journal of Pharmaceutical Sciences. 67:1978;1476-1478.
21. Upadhyay S.N., Dhawan S., Talwar G.P. "Antifertility effects of neem (Azadirachta indica) oil in male rats by single intra vas administration" an alternate approach to vasectomy. Journal of Andrology. 44:1993;27-281.