i-SNAREs: Inhibitory SNAREs that fine-tune the specificity of membrane fusion

Journal of Cell Biology

Volumn 164, Issue 1, 2004, Pages 79-88

  Varlamov, Oleg ^a   Volchuk, Allen ^a   Rahimian, Vahid ^a   Doege, Claudia A ^a   Paumet, Fabienne ^a   Eng, William S ^a   Arango, Nancy ^a   Parlati, Francesco ^a,c   Ravazzola, Mariella ^b   Orci, Lelio ^b   Söllner, Thomas H ^a   Rothman, James E ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^c RIGEL PHARMACEUTICALS INC   (United States)

Author keywords

Golgi; Gradient; Homotypic; Regulation; Vesicles

Indexed keywords

INHIBITORY SNARE PROTEIN; PROTEIN SUBUNIT; SNARE PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL SECRETION; CIS ISOMER; COMPLEX FORMATION; GOLGI COMPLEX; MEMBRANE FUSION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; TRANS ISOMER;

BINDING SITES; GOLGI APPARATUS; INTRACELLULAR MEMBRANES; MEMBRANE FUSION; MEMBRANE PROTEINS; PROTEIN BINDING; PROTEIN SUBUNITS; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SNARE PROTEINS; TRANS-GOLGI NETWORK; VESICULAR TRANSPORT PROTEINS;

EID: 0346492581     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200307066     Document Type: Article

References (32)

1. Acharya, U., R. Jacobs, J.M. Peters, N. Watson, M.G. Farquhar, and V. Malhotra. 1995. The formation of Golgi stacks from vesiculated Golgi membranes requires two distinct fusion events. Cell. 82:895-904.
2. Bock, J.B., H.T. Matern, A.A. Peden, and R.H. Scheller. 2001. A genomic perspective on membrane compartment organization. Nature. 409:839-841.
3. Brickner, J.H., J.M. Blanchette, G. Sipos, and R.S. Fuller. 2001. The Tlg SNARE complex is required for TGN homotypic fusion. J. Cell Biol. 155:969-978.
4. Coe, J.G., A.C. Lim, J. Xu, and W. Hong. 1999. A role for Tlg1 p in the transport of proteins within the Golgi apparatus of Saccharomyces cerevisiae. Mol. Biol. Cell. 10:2407-2423.
5. Fasshauer, D., W. Antonin, M. Margittai, S. Pabst, and R. Jahn. 1999. Mixed and non-cognate SNARE complexes. Characterization of assembly and biophysical properties. J. Biol. Chem. 274:15440-15446.
6. Fukuda, R., J.A. McNew, T. Weber, F. Parlati, T. Engel, W. Nickel, J.E. Rothman, and T.H. Söllner. 2000. Functional architecture of an intracellular membrane t-SNARE. Nature. 407:198-202.
7. Hardwick, K.G., and H.R. Pelham. 1992. Sed5 encodes a 39-kD integral membrane protein required for vesicular transport between the ER and the Golgi complex. J. Cell Biol. 119:513-521.
8. Holthuis, J.C., B.J. Nichols, S. Dhruvakumar, and H.R. Pelham. 1998. Two syntaxin homologues in the TGN/endosomal system of yeast. EMBO J. 17:113-126.
9. Hu, C., M. Ahmed, T.J. Melia, T.H. Söllner, T. Mayer, and J.E. Rothman. 2003. Fusion of cells by flipped SNAREs. Science. 300:1745-1749.
10. Lippincott-Schwartz, J., L.C. Yuan, J.S. Bonifacino, and R.D. Klausner. 1989. Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER. Cell. 56:801-813.
11. Lupashin, V.V., I.D. Pokrovskaya, J.A. McNew, and M.G. Waters, 1997. Characterization of a novel yeast SNARE protein implicated in Golgi retrograde traffic. Mol. Biol. Cell. 8:2659-2676.
12. McNew, J.A., M. Søgaard, N.M. Lampen, S. Machida, R.R. Ye, L. Lacomis, P. Tempst, J.E. Rothman, and T.H. Söllner. 1997. Ykt6p, a prenylated SNARE essential for endoplasmic reticulum-Golgi transport. J. Biol. Chem. 272:17776-17783.
13. McNew, J.A., J.G. Coe, M. Søgaard, B.V. Zemelman, C. Wimmer, W. Hong, and T.H. Söllner. 1998. Gos1p, a Saccharomyces cerevisiae SNARE protein involved in Golgi transport. FEBS Lett. 435:89-95.
14. McNew, J.A., T. Weber, F. Parlati, R.J. Johnston, T.J. Melia, T.H. Söllner, and J.E. Rothman. 2000a. Close is not enough: SNARE-dependent membrane fusion requires an active mechanism that transduces force to membrane anchors. J. Cell Biol. 150:105-117.
15. McNew, J.A., R. Fukuda, F. Parlati, R.J. Johnston, K. Paz, F. Paumet, T.H. Söllner, and J.E. Rothman. 2000b. Compartmental specificity of cellular membrane fusion encoded in SNARE proteins. Nature. 407:153-159.
16. Mollard, G.F., and T.H. Stevens. 1998. A human homolog can functionally replace the yeast vesicle-associated SNARE Vti1 in two vesicle transport pathways. J. Biol. Chem. 273:2624-2630.
17. Nichols, B.J., and H.R. Pelham. 1998. SNAREs and membrane fusion in the Golgi apparatus. Biochim. Biophys. Acta. 1404:9-31.
18. Parlati, F., T. Weber, J.A. McNew, B. Westermann, T.H. Söllner, and J.E. Rothman. 1999. Rapid and efficient fusion of phospholipid vesicles by the alpha-helical core of a SNARE complex in the absence of an N-terminal regulatory domain. Proc. Natl. Acad. Sci. USA. 96:12565-12570.
19. Parlati, F., J.A. McNew, R. Fukuda, R. Miller, T.H. Söllner, and J.E. Rothman. 2000. Topological restriction of SNARE-dependent membrane fusion. Nature. 407:194-198.
20. Parlati, F., O. Varlamov, K. Paz, J.A. McNew, D. Hurtado, T.H. Söllner, and J.E. Rothman. 2002. Distinct SNARE complexes mediating membrane fusion in Golgi transport based on combinatorial specificity. Proc. Natl. Acad. Sci. USA. 99:5424-5429.
21. Paumet, F., B. Brugger, F. Parlati, J.A. McNew, T.H. Söllner, and J.E. Rothman. 2001. A t-SNARE of the endocytic pathway must be activated for fusion. J. Cell Biol. 155:961-968.
22. Protopopov, V., B. Govindan, P. Novick, and J.E. Gerst. 1993. Homologs of the synaptobrevin/VAMP family of synaptic vesicle proteins function on the late secretory pathway in S. cerevisiae. Cell. 74:855-861.
23. Rabouille, C., T.P. Levine, J.M. Peters, and G. Warren. 1995. An NSF-like ATPase, p97, and NSF mediate cisternal regrowth from mitotic Golgi fragments. Cell. 82:905-914.
24. Sun, W., Q. Yan, T.A. Vida, and A.J. Bean. 2003. Hrs regulates early endosome fusion by inhibiting formation of an endosomal SNARE complex. J. Cell Biol. 162:125-137.
25. Sutton, R.B., D. Fasshauer, R. Jahn, and A.T. Brunger. 1998. Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution. Nature. 395:347-353.
26. Takizawa, P.A., J.K. Yucel, B. Veit, D.J. Faulkner, T. Deerinck, G. Soto, M. Ellisman, and V. Malhotra. 1993. Complete vesiculation of Golgi membranes and inhibition of protein transport by a novel sea sponge metabolite, ilimaquinone. Cell. 73:1079-1090.
27. Tsui, M.M., and D.K. Banfield. 2000. Yeast Golgi SNARE interactions are promiscuous. J. Cell Sci. 113:145-152.
28. Tsui, M.M., W.C. Tai, and D.K. Banfield. 2001. Selective formation of Sed5p-containing SNARE complexes is mediated by combinatorial binding interactions. Mol. Biol. Cell. 12:521-538.
29. Volchuk, A., M. Ravazzola, A. Perrelet, W. Eng, M. Di Liberto, O. Varlamov, M. Fukasawa, T. Engel, T.H. Söllner, J.E. Rothman, and L. Orci. 2004. Countercurrent distribution of two distinct SNARE complexes mediating transport within the Golgi stack. Mol. Biol. Cell. In press.
30. Weber, T., B.V. Zemelman, J.A. McNew, B. Westermann, M. Gmachl, F. Parlati, T.H. Söllner, and J.E. Rothman. 1998. SNAREpins: minimal machinery for membrane fusion. Cell. 92:759-772.
31. Yang, B., L. Gonzalez, Jr., R. Prekeris, M. Steegmaier, R.J. Advani, and R.H. Scheller. 1999. SNARE interactions are not selective. Implications for membrane fusion specificity. J. Biol. Chem. 274:5649-5653.
32. Zhang, T., and W. Hong. 2001. Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport. J. Biol. Chem. 276:27480-27487.