Synthesis and biological activities of 1,1′-diacyl-4,4,4′ ,4′-tetraalkyl dipiperazinium derivatives

Yaoxue Xuebao

Volumn 34, Issue 9, 1999, Pages 666-668

  Li, Runtao ^a   Cui, Jialing ^a   Cheng, Tieming ^a   Cai, Mengshen ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

1 1 dialkyl 4,4,4 ,4 tetraalkyl dipiperazinium dibromide; Analgesic; Sedative; Structure activity relationship

Indexed keywords

EID: 0346461957     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Cignarella Via. V. 3, 8-Diazabicyclo [3, 2, 1] octan derivatives having analgesic activity. WO 95/23152 CA 1996,124:55984h
2. 1HNMR conformational study of 3,8-diazabicyclo[3,2,1] octanes and related cis-2,6-dimethylpiperazines active on opioid receptors. Tetrahedron, 1992,48:159
3. Li RT, Chen HC, Yang JZ. Studies on antitumor drugs of piperazines: synthesis of dipiperazine diquaternary ammonium derivatives. Acta Pharm Sin, 1995,30:63
4. Li RT, Cao SL, Chen HC, et al. Synthesis and pharmacological activities of 1, 1-dialkyl-4-(3-bromopropionyl) piperazinium bromides. Acta Pharm Sin, 1996,31:757
5. Fan NT. Dictionary of Organic Synthesis. Beijing: Press of Beijing University of Science and Engineering, 1992. 337