Anthropometric analysis of homosexuals and heterosexuals: Implications for early hormone exposure

Hormones and Behavior

Volumn 45, Issue 1, 2004, Pages 31-39

  Martin, James T ^a   Nguyen, Duc Huu ^a  

^a WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

Author keywords

Bone morphology; Homosexuals; Steroids

Indexed keywords

SEX HORMONE;

ACROMION; ADULT; ANTHROPOMETRIC PARAMETERS; ARM; ARTICLE; BODY HEIGHT; BODY WEIGHT; BONE GROWTH; CHILDHOOD; CONTROLLED STUDY; FEMALE; HAND; HETEROSEXUALITY; HOMOSEXUALITY; HUMAN; ILIAC CREST; LEG; LONG BONE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PUBERTY; SEX DIFFERENCE; SEXUAL ORIENTATION;

EID: 0346460275     PISSN: 0018506X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yhbeh.2003.07.003     Document Type: Article

References (74)

1. Adkins-Regan E. Sex hormones and sexual orientation in animals. Psychobiology. 16:1988;335-348.
2. Baker F. Anthropological notes on the human hand. Am. Anthropol. 1:1888;51-76.
3. Blanchard R., Bogaert A.F. Biodemographic comparisons of homosexual and heterosexual men in the Kinsey interview data. Arch. Sex. Behav. 25:1996;551-579.
4. Blanchard R., Ellis L. Birth weight, sexual orientation and the sex of preceding siblings. J. Biosoc. Sci. 30:2001;451-467.
5. Bogaert A.F. Physical development and sexual orientation in women: height, weight and age of puberty comparisons. Personal. Indiv. Diff. 24:1998;115-121.
6. Bogaert A.F., Blanchard R. Physical development and sexual orientation in men: height, weight, and age of puberty differences. Personal. Indiv. Diff. 21:1996;77-84.
7. Bourguignon J.-P. Linear growth as a function of age at onset of puberty and sex steroid dosage: therapeutic implications. Endocr. Rev. 9(4):1988;467-488.
8. Brown W.M., Hines M., Fane B., Breedlove S.M. Masculinized finger length ratios in humans with congenital adrenal hyperplasia. Horm. Behav. 39:2001;325-326.
9. Buchanan J.R., Hospodar P., Myers C., Leuenberger P., Demers L.M. Effect of excess endogenous androgens on bone mineral density in young women. J. Clin. Endocrinol. Metab. 67(5):1988;937-943.
10. Caruso-Nicoletti M., Cassorla F., Skerda M., Ross J.L., Loriaux D.L., Cutler G.B. Jr. Short term, low dose estradiol accelerates ulnar growth in boys. J. Clin. Endocrinol. Metab. 61:1985;896-898.
11. Cohen J. A power primer. Psychol. Bull. 112:1992;155-159.
12. Colvard D.S., Eriksen E.F., Keeting P.E., Wilson E.M., Lubahn D.B., French F.S., Riggs B.L., Spelsberg T.C. Identification of androgen receptors in normal human osteoblast like cells. Proc. Natl. Acad. Sci. 86:1989;854-857.
13. Cutler G.B. Jr. The role of estrogen in bone growth and maturation during childhood and adolescence. J. Steroid Biochem. Mol. Biol. 61:1997;141-144.
14. Dubuc P.U. Body weight regulation in female rats following neonatal testosterone. Acta Endocrinol. (Copenh.). 81:1976;215-224.
15. Ehrhardt A.A., Evers K., Money J. Influence of androgen and some aspects of sexually dimorphic behavior in women with the late-treated adrenogenital syndrome. Johns Hopkins Med. J. 123:1968;115-122.
16. Eriksen E.F., Colvard D.S., Berg N.J., Graham M.L., Mann K.G., Spelsberg T.C. Evidence of estrogen receptors in normal osteoblast-like cells. Science. 241:1988;84-86.
17. Galluzzi F., Salti R., Bindi G., Pasquini E., La Cauza C. Adult height comparison between boys and girls with precocious puberty after long-term gonadotrophin-releasing hormone analogue therapy. Acta Paediatr. 87:1998;521-527.
18. Garn S.M., Burdi A.R., Babler W.J., Stinson S. Early prenatal attainment of adult metacarpal-phalangeal rankings and proportions. Am. J. Phys. Anthropol. 43:1975;327-332.
19. George R. Human finger types. Anat. Rec. 46:1930;199-204.
20. Grumbach M.M., Auchus R.J. Estrogen: consequences and implications of human mutations in synthesis and action. J. Clin. Endocrinol. Metab. 84:1999;4677-4694.
21. Harris E.F., Aksharanugraha K., Behrents R.G. Metacarpophalangeal length changes in humans during adulthood: a longitudinal study. Am. J. Phys. Anthropol. 87:1992;263-275.
22. Harrison G.A., Weiner J.S., Tanner J.M., Barnicot N.A. Human Biology. An Introduction to Human Evolution, Variation and Growth. 1964;Oxford Univ. Press, New York.
23. Ho K.Y., Evans W.S., Blizzard R.M., Veldhuis J.D., Merriam G.R., Samojlik E., Furlanetto R., Rogol A.D., Kaiser D.L., Thorner M.O. Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations. J. Clin. Endocrinol. Metab. 64(1):1987;51-58.
24. Hu S., Pattatucci A.M., Patterson C., Li L., Fulker D.W., Cherny S.S., Kruglyak L., Hamer D.H. Linkage between sexual orientation and chromosome Xq28 in males but not in females. Nat. Genet. 11(3):1995;248-256.
25. Hughes P.C.R., Tanner J.M. The effect of a single neonatal sex hormone injection on the growth of the rat pelvis. Acta Endocrinol. 77:1974;612-624.
26. Imperato-McGinley J., Peterson R.E., Gautier T., Sturla E. Androgens and the evolution of male-gender identity among pseudohermaphrodites with 5a-reductase deficiency. N. Engl. J. Med. 300:1979;1233-1237.
27. Jansson J.O., Eden S., Isaksson O. Sexual dimorphism in the control of growth hormone secretion. Endocr. Rev. 6:1985;128-150.
28. Jansson J.O., Ekberg S., Isaksson O., Mode A., Gustafsson J.A. Imprinting of growth hormone secretion, body growth, and hepatic steroid metabolism by neonatal testosterone. Endocrinology. 117:1985;1881-1889.
29. Kenyon F.E. Physique and physical health of female homosexuals. J. Neurol. Neurosurg. Psychiatry. 31:1968;487-489.
30. Kerrigan J.R., Rogol A.D. The impact of gonadal steroid hormone action on growth hormone secretion during childhood and adolescence. Endocr. Rev. 13:1992;281-298.
31. Klein K.O., Baron J., Colli M.J., McDonnell D.P., Cutler G.B. Estrogen levels in childhood determined by an ultrasensitive recombinant cell bioassay. J. Clin. Invest. 94:1994;2475-2480.
32. Komm B.S., Terpening C.M., Benz D.J., Graeme K.A., Gallegos A., Kore M., Greene G.L., O'Malley B.M., Hausster M.R. Estrogen binding, receptor mRNA, and biological response in osteobast-like osteosarcoma cells. Science. 241:1988;81-84.
33. Mann D.R., Akinbami M.A., Gould K.G., Tanner J.M., Wallen K. Neonatal treatment of male monkeys with a gonadotropin-releasing hormone agonist alters differentiation of central nervous system centers that regulate sexual and skeletal development. J. Clin. Endocrinol. Metab. 76:1993;1319-1324.
34. Manning J.T., Scutt D., Wilson J., Lewis-Jones D.I. The ratio of 2nd to 4th digit length: a predictor of sperm numbers and levels of testosterone, LH and oestrogen. Hum. Reprod. 13:1998;3000-3004.
35. Manosevitz M. The development of male homosexuality. J. Sex Res. 8:1972;31-40.
36. Maor G., Segev Y., Phillip M. Testosterone stimulates insulin-like growth factor-I and insulin-like growth factor-I-receptor gene expression in the mandibular condyle - a model of endochondral ossification. Endocrinology. 140:1999;1901-1910.
37. Maresh M.M. Linear growth of long bones of extremities from infancy through adolescence. Am. J. Dis. Child. 89:1955;725-742.
38. Marshall W.A., Tanner J.M. Puberty. Davis J.A., Dobbing J. Scientific Foundations of Paediatrics. 1974;124-151 William Heinemann Medical Books, LTD, London.
39. Martin J.T., Baum M.J. Neonatal exposure of female ferrets to testosterone alters sociosexual preferences in adulthood. Psychoneuroendocrinology. 11:1986;167-176.
40. Martin L.G., Clark J.W., Connor T.B. Growth hormone secretion enhanced by androgens. J. Clin. Endocrinol. Metab. 28:1968;425-430.
41. Masica D.N., Money J., Ehrhardt A.A. Fetal feminization and female gender identity in the testicular feminizing syndrome of androgen insensitivity. Arch. Sex. Behav. 1:1971;131-142.
42. Matuszczyk J.V., Fernandez-Guasti A., Larsson K. Sexual orientation, proceptivity, and receptivity in the male rat as a function of neonatal hormonal manipulation. Horm. Behav. 22:1988;362-379.
43. Mauras N., Rogol A.D., Haymond M.W., Veldhuis J.D. Sex steroids, growth hormone, insulin-like growth factor-1: neuroendocrine and metabolic regulation in puberty. Horm. Res. 45:1996;74-80.
44. McFadden D., Shubel E. Relative lengths of fingers and toes in human males and females. Horm. Behav. 42:2002;492-500.
45. McFadden D., Shubel E. The relationship between otoacoustic emissions and relative lengths of fingers and toes in humans. Horm. Behav. 43:2003;421-429.
46. Mendonca B.B., Inacio M., Arnhold I., Costa E., Bloise W., Martin R.M., Denes F.T., Silva F.A., Andersson S., Lindqvist A., Wilson J.D. Male pseudohermaphroditism due to 17 beta-hydroxysteroid dehydrogenase 3 deficiency: diagnosis, psychological evaluation and management. Medicine. 79(5):2000;299-307.
47. Meyer-Bahlburg H.F.L. Psychoneuroendocrinology and sexual pleasure: the aspect of sexual orientation. Abramson P.R., Pinkerton S.D. Sexual Nature Sexual Culture. 1995;135-153 University of Chicago Press, Chicago, IL.
48. Meyerson B.J., Eliasson M., Hetta J. Sex-specific orientation in female and male rats: development and effects of early endocrine manipulation. Adv. Biosci. 25:1978;451-460.
49. Morishima A., Grumbach M.M., Simpson E.R., Fisher C., Qin K. Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J. Clin. Endocrinol. Metab. 80:1995;3689-3698.
50. Munoz-Torres M., Jodar E., Quesada M., Escobar-Jimenez F. Bone mass in androgen-insensitivity syndrome: response to hormonal replacement therapy. Calcif. Tissue Int. 57(2):1995;94-96.
51. Oliver G. Practical Anthropology. 1969;Charles Thomas Publ. Springfield, IL.
52. Parker M.W., Johanson A.J., Rogol A.D., Kaiser D.L., Blizzard R.M. Effect of testosterone on somatomedin-C concentrations in prepubertal boys. J. Clin. Endocrinol. Metab. 58:1984;87-90.
53. Phelps V.R. Relative index finger length as a sex-influenced trait in man. Am. J. Hum. Genet. 4:1952;72-89.
54. Rahman Q., Wilson G.D. Sexual orientation and the 2nd to 4th finger length ratio: evidence for organizing effects of sex hormones or developmental instability? Psychoneuroendocrinology. 28:2003;288-303.
55. Robinson S.J., Manning J.T. The ratio of 2nd to 4th digit length and male homosexuality. Evol. Hum. Behav. 21:2000;333-345.
56. Ross J.L., Cassorla F.G., Skerda M.C., Valk I.M., Loriaux D.L., Cutler G.B. Jr. A preliminary study of the effect of estrogen dose on growth in Turner's syndrome. N. Engl. J. Med. 309:1983;1104-1106.
57. Royer P. Growth and development of bony tissues. Davis J.A., Dobbing J. Scientific Foundations of Paediatrics. 1974;376-399 William Heinemann Medical Books, LTD, London.
58. Saghir M.T., Robins E. Male and Female Homosexuality: a Comprehensive Investigation. 1973;Williams & Wilkins, Baltimore, MD.
59. Sandstedt J., Ohlsson C., Norjavaara E., Nilsson J., Tornell J. Disproportional bone growth and reduced weight gain in gonadectomized male bovine growth hormone transgenic and normal mice. Endocrinology. 135:1994;2574-2580.
60. Sasano H., Uzuki M., Sawai T., Nagura H., Matsunaga G., Kashimoto O., Harada N. Aromatase in human bone tissue. J. Bone Miner. Res. 12(9):1997;1416-1423.
61. Smith E.P., Boyd J., Frank G.R., Takahashi H., Cohen R.M., Specker B., Williams T.C., Lubahn D.B., Korach K.S. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N. Engl. J. Med. 331:1994;1056-1061.
62. Somana R., Visessuwan S., Samritong A., Holand R.C. Effect of neonatal androgen treatment and orichidectomy on pituitary levels of growth hormone in the rat. J. Endocrinol. 79:1978;399-400.
63. Stein E. The Mismeasure of Desire. 1999;Oxford Univ. Press, New York.
64. Stratakis C.A., Vottero A., Brodie A., Kirschner L.S., DeAtkine D., Lu Q., Yue W.et al. The aromatase excess syndrome is associated with feminization of both sexes and autosomal dominant transmission of aberrant P450 aromatase gene transcription. J. Clin. Endocrinol. Metab. 83(4):1998;1348-1357.
65. Tanner J.M., Whitehouse R.H., Takaishi M. Standards from birth to maturity for height, weight, height velocity, and weight velocity: British children, 1965. II. Arch. Dis. Child. 41:1966;613-635.
66. Tanner J.M., Goldstein H., Whitehouse R.H. Standards for children's height at ages 2-9 years allowing for heights of parents. Arch. Dis. Child. 45:1970;755-762.
67. Tanner J.M., Whitehouse R.H., Hughes P.C., Carter B.S. Relative importance of growth hormone and sex steroids for the growth at puberty of trunk length, limb length, and muscle width in growth hormone-deficient children. J. Pediatr. 89(6):1976;1000-1008.
68. Taylor H.S., Arci A., Olive D., Igarashi P. HoxA10 is expressed in response to sex steroids at the time of implantation in the human endometrium. J. Clin. Invest. 101:1998;1379-1384.
69. Tyrrell A.R., Reilly T., Troup J.D. Circadian variation in stature and the effect of spinal loading. Spine. 10:1985;161-164.
70. Weil A. Die Koerpermasse der Homosexuellen als Ausdrucksform ihrer besonderen Veranlagung. Jahrb. sexuelle Zwischenstufen. 21(3/4):1921;113-120.
71. Weisman Y., Cassorla F., Malozowski S., Krieg R.J. Jr., Goldray D., Kaye A.M., Somjen D. Sex-specific response of bone cells to gonadal steroids: modulation in perinatally androgenized females and in testicular feminized male rats. Steroids. 58:1993;126-133.
72. Williams T.J., Pepitone M.E., Christensen S.E., Cooke B.M., Huberman A.D., Breedlove N.J., Breedlove T.J., Jordan C.L., Breedlove S.M. Finger-length ratios and sexual orientation. Nature. 404:2000;455-456.
73. Wolff G., Steggerda M. Female-male index of body build in negroes and whites: an interpretation of anatomical sex differences. Hum. Biol. 15(2):1943;127-152.
74. Zucker K.J., Bradley S.J., Fleming S., Hood J. Psychosexual development of women with congenital adrenal hyperplasia. Horm. Behav. 30:1996;300-318.