Evaluation of immunogenicity and protective efficacy of a Microsporum canis metalloprotease subunit vaccine in guinea pigs

FEMS Immunology and Medical Microbiology

Volumn 40, Issue 1, 2004, Pages 75-80

  Vermout, Sandy M ^a   Brouta, Frédéric D ^a   Descamps, Frédéric F ^a   Losson, Bertrand J ^a   Mignon, Bernard R ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Dermatophyte; Dermatophyte vaccine; Metalloprotease; Microsporum canis

Indexed keywords

FUNGAL ENZYME; FUNGUS VACCINE; MICROSPORUM CANIS RECOMBINANT METALLOPROTEASE 3; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DERMATOMYCOSIS; DISEASE MODEL; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FUNGAL STRAIN; GUINEA PIG; HUMORAL IMMUNITY; IMMUNOGENICITY; INFECTION PREVENTION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE TRANSFORMATION TEST; MICROSPORUM CANIS; MYCOSIS; NONHUMAN; PRIORITY JOURNAL; VACCINATION;

EID: 0346460241     PISSN: 09288244     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-8244(03)00296-7     Document Type: Article

References (41)

1. Lunder M., Lunder M. Is Microsporum canis infection about to become a serious dermatological problem? Dermatology. 184:1992;87-89.
2. Gudding R., Lund A. Immunoprophylaxis of bovine dermatophytosis. Can. Vet. J. 36:1995;302-306.
3. Rybnikar A., Chumela J., Vrzal V., et al. Prophylactic and therapeutic use of a vaccine against trichophytosis in a large herd of silver foxes and arctic foxes. Acta Vet. Brno. 60:1991;285-288.
4. Gordon P.J., Bond R. Efficacy of a live attenuated Trichophyton verrucosum vaccine for control of bovine dermatophytosis. Vet. Rec. 139:1996;395-396.
5. Bratberg A.M., Solbakk I.T., Gyllensvaan C., et al. Efficacy of an inactivated and a live bovine ringworm vaccine in an experimental challenge study (abstract). Proc. Annu. Meet. Am. Acad. Vet. Dermatol. 15:1999;113-114.
6. Elad D., Segal E. Immunogenicity in calves of a crude ribosomal fraction of Trichophyton verrucosum: a field trial. Vaccine. 13:1995;83-87.
7. Elad D., Segal E. Immunogenicity in guinea pigs of a crude ribosomal fraction from Microsporum canis. Vaccine. 12:1994;134-138.
8. Pier A.C., Hodges A.B., Lauze J.M., Raisbeck M. Experimental immunity to Microsporum canis and cross reactions with other dermatophytes of veterinary importance. J. Med. Vet. Mycol. 33:1995;93-97.
9. Wawrzkiewicz K., Ziolkowska G. Specific immunoprophylaxis in Microsporum canis infection in guinea pigs. J. Mycol. Méd. 6:1996;56-62.
10. Bredahl L.K., Bratberg A.M., Solbakk I.T., et al. Efficacy of an experimental Microsporum canis vaccine in farmed foxes (abstract). Vet. Dermatol. 11:2000;39.
11. Deboer D.J., Moriello K.A. The immune response to Microsporum canis induced by a fungal cell wall vaccine. Vet. Dermatol. 5:1994;47-55.
12. Deboer D.J., Moriello K.A. Investigations of a killed dermatophyte cell wall vaccine against infection with Microsporum canis in cats. Res. Vet. Sci. 59:1995;110-113.
13. Deboer D.J., Moriello K.A., Blum J.L., Volk L.M., Bredahl L.K. Safety and immunologic effects after inoculation of inactivated and combined live-inactivated dermatophytosis vaccines in cats. Am. J. Vet. Res. 63:2000;1532-1537.
14. ® Dermatophyton - results of a field-study in eleven German counties. Prakt. Tierarzt. 81:2000;574-578.
15. Brouta F., Descamps F., Fett T., Losson B., Gerday C., Mignon B. Purification and characterization of a 43.5 kDa keratinolytic metalloprotease from Microsporum canis. Med. Mycol. 39:2001;269-275.
16. Brouta F., Descamps F., Monod M., Vermout S., Losson B., Mignon B. Secreted metalloprotease gene family of Microsporum canis. Infect. Immun. 70:2002;5676-5683.
17. Brouta, F., Descamps, F., Monod, M., Vermout, S., Losson, B. and Mignon, B. (2003) Humoral and cell-mediated response to a recombinant keratinolytic metalloprotease (r-MEP3) from Microsporum canis in experimentally infected guinea pigs. Med. Mycol. (in press).
18. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
19. Van Cutsem J. Animal models for dermatomycotic infections. Curr. Top. Med. Mycol. 3:1989;1-35.
20. Mignon B., Losson B. Prevalence and characterization of Microsporum canis carriage in cats. J. Med. Vet. Mycol. 35:1997;249-256.
21. Mignon B., Leclipteux T., Focant C., Nikkels A., Piérard G., Losson B. Humoral and cellular immune response to a crude exo-antigen and purified keratinase of Microsporum canis in experimentally infected guinea pigs. Med. Mycol. 37:1999;123-129.
22. Jones H.E., Reinhardt J.H., Rinaldi M.G. Acquired immunity to dermatophytes. Arch. Dermatol. 109:1974;840-848.
23. Deboer D.J., Moriello K.A. Humoral and cellular immune responses to Microsporum canis in naturally occurring feline dermatophytosis. J. Med. Vet. Mycol. 31:1993;121-132.
24. Sparkes A.H., Stokes C.R., Gruffydd-Jones T.J. Humoral immune responses in cats with dermatophytosis. Am. J. Vet. Res. 54:1993;1869-1873.
25. Casadevall A. Antibody immunity and invasive fungal infections. Infect. Immun. 63:1995;4211-4218.
26. Casadevall A., Feldmesser M., Pirofski L. Induced humoral immunity and vaccination against major human fungal pathogens. Curr. Opin. Microbiol. 5:2002;386-391.
27. Bromuro C., Torosantucci A., Chiani P., Conti S., Polonelli L., Cassone A. Interplay between protective and inhibitory antibodies dictates the outcome of experimentally disseminated Candidiasis in recipients of a Candida albicans vaccine. Infect. Immun. 70:2002;5462-5470.
28. Woodfolk J.A., Slunt J.B., Deuell B., Hayden M.L., Platts-Mills T.A. Definition of a Trichophyton protein associated with delayed hypersensitivity in humans. Evidence for immediate (IgE and IgG4) and delayed hypersensitivity to a single protein. J. Immunol. 156:1996;1695-1701.
29. Sudowe S., Arps V., Vogel T., Kolsch E. The role of interleukin-4 in the regulation of sequential isotype switch from immunoglobulin G1 to immunoglobulin E antibody production. Scand. J. Immunol. 51:2000;461-471.
30. Calderon R.A., Hay R.J. Cell-mediated immunity in experimental murine dermatophytosis II. Adoptive transfer of immunity to dermatophyte infection by lymphoid cells from donors with acute or chronic infections. Immunology. 53:1984;465-472.
31. Deboer D.J., Moriello K.A., Cooley A.J. Immunological reactivity to intradermal dermatophyte antigens in cats with dermatophytoses. Vet. Dermatol. 2:1991;59-67.
32. Sparkes A.H., Stokes C.R., Gruffydd-Jones T.J. Experimental Microsporum canis infection in cats: correlation between immunological and clinical observations. J. Med. Vet. Mycol. 33:1995;177-184.
33. Sparkes A.H., Gruffydd-Jones T.J., Stokes C.R. Acquired immunity in experimental feline Microsporum canis infection. Res. Vet. Sci. 61:1996;165-168.
34. Kerbs S., Greenberg J., Jesrani K. Temporal correlation of lymphocyte blastogenesis, skin test responses, and erythema during dermatophyte infections. Clin. Exp. Immunol. 27:1977;526-530.
35. Hay, R.J. (1997) Fungal infections. In: Fungal Disease. Biology, Immunology and Diagnosis (Jacobs, P.H. and Nall, L., Eds.), pp. 209-218. Marcel Dekker, New York.
36. Ogawa H., Summerbell R.C., Clemons K.V., Koga T., Ran Y.P., Rashid A., Sohnle P.G., Stevens D.A., Tsuboi R. Dermatophytes and host defence in cutaneous mycoses. Med. Mycol. 36:1998;166-173.
37. Slunt J.B., Taketomi E.A., Woodfolk J.A., Hayden M.L., Platts-Mills T.A. The immune response to Trichophyton tonsurans: distinct T cell cytokine profiles to a single protein among subjects with immediate and delayed hypersensitivity. J. Immunol. 157:1996;5192-5197.
38. Rudd P.M., Elliott T., Cresswell P., Wilson I.A., Dwek R.A. Glycosylation and the immune system. Science. 291:2001;2370-2376.
39. Bromuro C., La Valle R., Sandini S. A 70-kilodalton recombinant heat shock protein of Candida albicans is highly immunogenic and enhances systemic murine candidiasis. Infect. Immun. 66:1998;2154-2162.
40. Comoy E.E., Capron A., Typhronitis G. In vivo induction of type 1 and 2 immune responses against protein antigens. Int. Immunol. 9:1997;523-531.
41. Moingeon P., Haensler J., Lindberg A. Towards the rational design of Th1 adjuvants. Vaccine. 19:2001;4363-4372.