The effects and mechanisms of glycyrrhizin on the TNBS-induced pancreatic fibrosis in rat

Chinese Pharmacological Bulletin

Volumn 19, Issue 12, 2003, Pages 1424-1427

  Wu, Kai ^a   Zhang, Ru Ling ^a   Wang, Xing Peng ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Glycyrrhizin; Pancreatic fibrosis; Pancreatic stellate cell

Indexed keywords

ALPHA ACTIN; AMYLASE; COLLAGEN TYPE 1; EOSIN; GLYCYRRHIZIC ACID; HEMATOXYLIN; HYALURONIC ACID; TRANSFORMING GROWTH FACTOR BETA1; TRINITROBENZENESULFONIC ACID;

ACINAR CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT; CELL ACTIVATION; CELL COUNT; CHRONIC PANCREATITIS; CONTROLLED STUDY; CYSTIC FIBROSIS; DRUG EFFECT; DRUG MECHANISM; ENZYMATIC ASSAY; EXTRACELLULAR MATRIX; FIBROSIS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MAST CELL; MAST CELL DEGRANULATION; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; RAT; RAT STRAIN; STAINING; STELLATE CELL; WESTERN BLOTTING;

EID: 0346394171     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. 4- plus ethanol-induced liver cirrhosis in rats. Liver, 1998;18(3):180-5
2. Bachem MG, Schneider E, Grob H et al. Identification, culture, characterization of pancreatic stellate cells in rats and humans. Gastroenterology, 1998;115(2):421-32
3. Jeong HG, You HJ, Park SJ et al. Hepatoprotective effects of 18beta-glycyrrhetinic acid on carbon tetrachloride-induced liver injury: Inhibition of cytochrome P450 2E1 expression. Pharmacol Res, 2002;46(3):221-7
4. Xu X, Weksler-Zagen S, Prikarsky A et al. Mast cells involvement in the inflammation and fibrosis development of the TNBS-induced rat model of colitis. Scand J Gastroenterology, 2002;37 (3):330-7
5. Garbuzenko E, Nagler A, Pickholtz D et al. Human mast cells stimulate fibroblast proliferation, collagen synthesis and lattice contraction: A direct role for mast cells in skin fibrosis. Clin Exp Allergy, 2002;32(2):237-46