Oxygen Transport Dynamics after Resuscitation with a Conjugated Hemoglobin Solution

Archives of Surgery

Volumn 139, Issue 1, 2004, Pages 55-60

  Wirk, Shaheen ^a   Vaslef, Steven N ^a,b  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; POLYETHYLENE DERIVATIVE; PYRIDOXALATED HEMOGLOBIN POLYETHYLENE CONJUGATE; PYRIDOXINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL BLOOD; ARTICLE; BLEEDING; CONTROLLED STUDY; CRYSTALLOID; ERYTHROCYTE; FEMALE; HEART INDEX; HEART RATE; HEMODYNAMICS; LUNG ARTERY PRESSURE; MEAN ARTERIAL PRESSURE; NONHUMAN; OXYGEN TRANSPORT; PLASMA; PRIORITY JOURNAL; RESUSCITATION; SWINE; VENOUS BLOOD;

ANALYSIS OF VARIANCE; ANIMALS; BLOOD GAS ANALYSIS; DISEASE MODELS, ANIMAL; FEMALE; HEMODYNAMIC PROCESSES; HEMOGLOBINS; OXYGEN CONSUMPTION; POLYETHYLENE GLYCOLS; PROBABILITY; RESPIRATORY TRANSPORT; RESUSCITATION; SENSITIVITY AND SPECIFICITY; SHOCK, HEMORRHAGIC; SWINE;

EID: 0346368239     PISSN: 00040010     EISSN: None     Source Type: Journal    
DOI: 10.1001/archsurg.139.1.55     Document Type: Article

References (11)

1. Gould SA, Moore, EE, Moore FA, et al. Clinical utility of human polymerized hemoglobin as a blood substitute after acute trauma and urgent surgery. J Trauma. 1997;43:325-332.
2. Gould SA, Moore EE, Hoyt DB, et al. The first randomized trial of human polymerized hemoglobin as a blood substitute in acute trauma and emergent surgery. J Am Coll Surg. 1998;187:113-120.
3. Gould SA, Moore EE, Hoyt DB, et al. The life-sustaining capacity of human polymerized hemoglobin when red cells might be unavailable. J Am Coll Surg. 2002;195:445-455.
4. Noone RB Jr, Mythen MG, Vaslef SN. Effect of alpha(alpha)-cross-linked hemoglobin and pyridoxalated hemoglobin polyoxyethylene conjugate solutions on gastrointestinal regional perfusion in hemorrhagic shock. J Trauma. 1998;45:457-469.
5. Glasgow SC, Shah AS, Noone RB Jr, et al. Comparison of various hemoglobin polyoxyethylene conjugate solutions as resuscitative fluids after hemorrhagic shock. J Trauma. 2000;48:884-893.
6. Vaslef SN, Kaminski BJ, Talarico TL. Oxygen transport dynamics of acellular hemoglobin solutions in an isovolemic hemodilution model in swine. J Trauma. 2001;51:1153-1160.
7. Yabuki A, Yamaji K, Ohki H, Iwashita Y. Characterization of a pyridoxalated hemoglobin-polyoxyethylene conjugate as a physiologic oxygen carrier. Transfusion. 1990;30:516-520.
8. Hess JR, MacDonald VW, Brinkley WW. Systemic and pulmonary hypertension after resuscitation with cell-free hemoglobin. J Appl Physiol 1993;74:1769-1778.
9. Rosen AL, Sehgal LR, Gould SA, Sehgal HL, Moss GS. Methodology to assess the oxygen concentration of red cells and stroma-free hemoglobin solutions. Crit Care Med. 1986;14:147-150.
10. Gould SA, Rosen AL, Sehgal LR, Sehgal HL, Moss GS. Polymerized pyridoxalated hemoglobin. J Trauma. 1986;26:903-908.
11. Gould SA, Moss GS. Clinical development of human polymerized hemoglobin as a blood substitute. World J Surg. 1996;20:1200-1207.