Low-dose airborne endotoxin exposure enhances bronchial responsiveness to inhaled allergen in atopic asthmatics [3]

Journal of Allergy and Clinical Immunology

Volumn 112, Issue 6, 2003, Pages 1241-1243

  Boehlecke, Brian ^a,c   Hazucha, Milan ^a,c   Alexis, Neil E ^b,c   Jacobs, Robert ^d   Reist, Parker ^a   Bromberg, Philip A ^a,c   Peden, David B ^a,b,c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b Department of Pediatrics ^*  (United States)

^c Department of Pediatrics   (United States)

^d EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; ENDOTOXIN; HOUSE DUST ALLERGEN; OZONE;

ADULT; ALLERGIC ASTHMA; ALLERGY; AMBIENT AIR; ASTHMA; BRONCHUS HYPERREACTIVITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; ENVIRONMENTAL EXPOSURE; EOSINOPHILIA; FORCED EXPIRATORY VOLUME; GRAM NEGATIVE BACTERIUM; HUMAN; IMMUNE RESPONSE; LETTER; LIMULUS LYSATE TEST; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPIROMETRY; TH2 CELL;

EID: 0346365284     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2003.08.052     Document Type: Letter

References (6)

1. Liu AH. Endotoxin exposure in allergy and asthma: reconciling a paradox. J Allergy Clin Immunol 2002;109:379-92.
2. Michel O, Kips J, Duchateau J, Vertongen F, Robert L, Collet H, et al. Severity of asthma is related to endotoxin in house dust. Am J Respir Crit Care Med 1996;154:1641-6.
3. Eldridge MW, Peden DB. Allergen provocation augments endotoxin-induced nasal inflammation in subjects with atopic asthma. J Allergy Clin Immunol 2000;105:475-81.
4. Alexis N, Eldridge M, Reed W, Bromberg P, Peden DB. CD14-dependent airway neutrophil response to inhaled LPS: role of atopy. J Allergy Clin Immunol 2001;107:31-5.
5. Kehrl HR, Peden DB, Ball B, Folinsbee LJ, Horstman D. Increased specific airway reactivity of persons with mild allergic asthma after 7.6 hours of exposure to 0.16 ppm ozone. J Allergy Clin Immunol 1999;104:1198-204.
6. Teeuw KB, Vandenbroucke-Grauls CM, Verhoef J. Airborne gram-negative bacteria and endotoxin in sick building syndrome: a study in Dutch governmental office buildings. Arch Intern Med 1994;154:2339-45.