Screening Tests to Diagnose Hyperadrenocorticism in Cats and Dogs

Compendium on Continuing Education for the Practicing Veterinarian

Volumn 22, Issue 1, 2000, Pages 17-31

  Zerbe, Carole A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0346355265     PISSN: 01931903     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Jones CA, Refsal KR, Lippert AC, et al: Changes in adrenal cortisol secretion as reflected in the urinary cortisol/creatinine ratio in dogs. Domest Anim Endocrinol 7:559-572, 1990.
2. Behrend EN, Kemppainen RJ, Young DW: Effect of storage conditions on cortisol, total thyroxine, and free thyroxine concentrations in serum and plasma of dogs. JAVMA 10: 1564-1568, 1998.
3. Feldman EC, Nelson RW, Feldman MS: Use of low-and high-dose dexamethasone tests for distinguishing pituitary-dependent from adrenal tumor hyperadrenocorticism in dogs. JAVMA 209:772-775, 1996.
4. Feldman EC, Nelson RW: Hyperadrenocorticism (Cushing's syndrome), in Canine and Feline Endocrinology and Reproduction. Philadelphia, WB Saunders Co, 1996, pp 187-265.
5. Zerbe CA, Nachreiner RF, Refsal KR, et al: Adrenal function testing in dogs with hyperadrenocorticism (Abstr). Proc 5th ACVIM Forum:883, 1987.
6. Frank LA, Oliver DW: Comparison of serum cortisol concentrations in clinically normal dogs after administration of freshly reconstituted versus reconstituted and stored frozen cosyntropin. JAVMA 212:1569-1571, 1998.
7. Dickstein G, Schectiner C, Nicholson WE, et al: Adrenocorticotropin stimulation test: Effects of basal cortisol level, time of day, and suggested new sensitive low dose test. J Clin Endocrinol Metab 72:773-778, 1991.
8. Feldman EC: Comparison of ACTH response and dexamethasone suppression as screening tests in canine hyperadrenocorticism. JAVMA 182:506-510, 1982.
9. Hansen B, Kemppainen RJ, MacDonald JM: Synthetic ACTH (cosyntropin) stimulation tests in normal dogs: Comparison of intravenous and intramuscular administration. JAAHA 30:38-41, 1994.
10. Kemppainen RJ, Zerbe CA: Common endocrine diagnostic tests: Normal values and interpretation, in Kirk RW (ed): Current Veterinary Therapy X. WB Saunders Co, 1989, pp 961-968.
11. Kerl ME, Peterson ME, Wallace MS, et al: Evaluation of a low-dose synthetic adrenocorticotropic hormone stimulation test in clinically normal dogs and dogs with naturally developing hyperadrenocorticism. JAVMA 214:1497-1501, 1999.
12. Kemppainen RJ, Mansfield PD, Sartin DL: Endocrine responses of normal cats to TSH and synthetic ACTH administration. JAAHA 20:737-740, 1984.
13. Peterson ME, Kintzer PP, Foodman MS, et al: Adrenal function in the cat: Comparison of the effects of cosyntropin (synthetic ACTH) and corticotropin gel stimulation. Res Vet Sci 37:331-333, 1984.
14. Smith MC, Feldman EC: Plasma endogenous ACTH concentrations and plasma cortisol responses to synthetic ACTH and dexamethasone sodium phosphate in healthy cats. Am J Vet Res 48:1719-1724, 1987.
15. Sparkes AT, Adams DT, Douthwaite JA, Gruffydd-Jones TJ: Assessment of adrenal function in cats: Response to intravenous synthetic ACTH. J Small Anim Pract 31:2-5, 1990.
16. Zerbe CA, Refsal KR, Schall WD, et al: Adrenal function in 15 dogs with insulin-dependent diabetes mellitus. JAVMA 193:454-456, 1988.
17. Zerbe CA, Refsal KR, Peterson ME, et al: Effect of nonadrenal illness on adrenal function in the cat. Am J Vet Res 48:451-454, 1987.
18. Chastain CB, Franklin RT, Ganjam VK, Madsen RW: Evaluation of the hypothalamic pituitary-adrenal axis in clinically stressed dogs. JAAHA 22:435-442, 1986.
19. Kaplan AJ, Peterson ME, Kemppainen RJ: Effects of disease on the results of diagnostic tests for use in detecting hyperadrenocorticism in dogs. JAVMA 207:445-451, 1995.
20. Peterson ME: Hyperadrenocorticism. Vet Clin North Am Small Anim Pract 14:731-749, 1984.
21. Peterson ME, Gilbertson SR, Drucker WD: Plasma cortisol response to exogenous ACTH in 22 dogs with hyperadrenocorticism caused by adrenocortical neoplasia. JAVMA 180: 542-544, 1982.
22. van Liew CH, Greco DS, Salman MD: Comparison of results of adrenocorticotropic hormone stimulation and low-dose dexamethasone suppression tests with necropsy findings in dogs: 81 cases (1985-1995). JAVMA 21:322-325, 1997.
23. Duesberg C, Peterson ME: Adrenal disorders in cats. Vet Clin North Am Small Anim Pract 27:321-347, 1997.
24. Daley CA, Zerbe CA, Schick RO, et al: Use of metyrapone to treat pituitary-dependent hyperadrenocorticism in a cat with large cutaneous wounds. JAVMA 202:956-960, 1993.
25. Kintzer PP, Peterson ME: Mitotane treatment of 32 dogs with cortisol-secreting adrenocortical neoplasms. JAVMA 250:54-61, 1994.
26. Feldman EC, Bruyette DS, Nelson RW, et al: Plasma cortisol response to ketoconazole administration in dogs with hyperadrenocorticism. JAVMA 197:71-74, 1990.
27. Mack RE, Feldman EC: Comparison of two low-dose dexamethasone suppression protocols as screening and discrimination tests in dogs with hyperadrenocorticism. JAVMA 197:1603-1606, 1990.
28. Medleau L, Cowan LA, Cornelius LM: Adrenal function testing in the cat: The effect of low dose intravenous dexamethasone administration. Res Vet Sci 42:260-261, 1987.
29. Peterson ME, Graves TK: Effect of low dosages of intravenous dexamethasone on serum cortisol concentrations in the normal cat. Res Vet Sci 44:38-40, 1988.
30. Kemppainen RJ, Peterson ME: Circulating concentration of dexamethasone in healthy dogs, dogs with hyperadrenocorticism, and dogs with nonadrenal illness during dexamethasone testing. Am J Vet Res 54:1765-1769, 1993.
31. Rijnberk A, Van Wees A, Mol JA: Assessment of two tests for the diagnosis of canine hyperadrenocorticism. Vet Rec 122:178-180, 1988.
32. van Vonderen IK, Koistra HS, Rijnberk A: Influence of veterinary care on the urinary corticoid:creatinine ratio in dogs. J Vet Intern Med 12:431-435, 1998.
33. Smiley L, Peterson ME: Evaluation of a urine cortisol:creatinine ratio as a screening test for hyperadrenocorticism in dogs. J Vet Intern Med 7:163-168, 1993.
34. Feldman EC, Mack RE: Urine cortisol:creatinine ratio as a screening test for hyperadrenocorticism in dogs. JAVMA 200:1637-1641, 1992.
35. Goosens MM, Meyer HP, Voorhout G, et al: Urinary excretion of glucocorticoids in the diagnosis of hyperadrenocorticism in cats. Domest Anim Endocrinol 12:355-362, 1995.
36. Eiler H, Oliver JW: Combined dexamethasone suppression and cosyntropin (synthetic ACTH) stimulation test in the dog: New approach to testing of adrenal gland function. Am J Vet Res 41:1243-1246, 1980.
37. Eiler H, Oliver JW, Legendre AM, et al: Stages of hyperadrenocorticism: Response of hyperadrenocorticoid dogs to the combined dexamethasone suppression/ACTH stimulation tests. JAVMA 185:289-294, 1984.
38. Feldman EC: Evaluation of a combined dexamethasone suppression/ACTH stimulation test in dogs with hyperadrenocorticism. JAVMA 187:49-53, 1985.
39. Feldman EC: Evaluation of a six-hour combined dexamethasone suppression/ACTH stimulation test in dogs with hyperadrenocorticism. JAVMA 189:1562-1566, 1986.
40. Zerbe CA, Nachreiner RF, Dunstan RW, et al: Hyperadrenocorticism in a cat. JAVMA 190:559-563, 1987.
41. Peterson ME, Steele P: Pituitary-dependent hyperadrenocorticism in a cat. JAVMA 189:680-683, 1986.
42. Vial GC, Stabenfeldt GH, Franti CE, Ling GL: Influence of environment on adrenal cortical response to ACTH stimulation in clinically normal dogs. Am J Vet Res 40:919-921, 1979.
43. Zenoble RD, Kemppainen RJ: Adrenocortical suppression by topically applied corticosteroids in healthy dogs. JAVMA 191:685-688, 1987.
44. Stolp R, Rijnberk A, Meijer JC, et al: Urinary corticoids in the diagnosis of canine hyperadrenocorticism. Res Vet Sci 34:141-144, 1983.
45. Roberts SM, Lavach JD, Macy DW, et al: Effect of ophthalmic prednisolone acetate on the canine adrenal gland and hepatic function. Am J Vet Res 45:1711-1714, 1984.
46. Moriello KA, Fehrer-Sawyer SL, Meyer DJ, et al: Adrenocortical suppression associated with topical otic administration of glucocorticoids in dogs. JAVMA 193:329-331, 1988.
47. Chauvet AE, Feldman EC, Kass PH: Effects of phenobarbital administration on results of serum biochemical analyses and adrenocortical function tests in epileptic dogs. JAVMA 207:1305-1307, 1995.
48. Dyer ER, Monroe WE, Forrester SD: Effects of short-and long-term administration of phenobarbital on endogenous ACTH concentration and results of ACTH stimulation tests in dogs. JAVMA 205:315-318, 1994.