Enantioselective Synthesis and Biological Activity of (3S,4R)- and (3S,4S)-3-Hydroxy-4-hydroxymethyl-4-butanolides in Relation to PGE2

Journal of Medicinal Chemistry

Volumn 47, Issue 2, 2004, Pages 292-295

  Miranda, Pedro O ^a   Estévez, Francisco ^b   Quintana, José ^b   Garcia, Candelaria I ^a   Brouard, Ignacio ^a   Padrón, Juan I ^a   Pivel, Juan P ^c   Bermejo, Jaime ^a  

^a INSTITUTO DE PRODUCTOS NATURALES Y AGROBIOLOGÍA   (Spain)

^b UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

^c Industrial Cantabria Farmaceutica S A   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 4 HYDROXYMETHYL 4 BUTANOLIDE; BUTYROLACTONE; PROSTAGLANDIN E2; PROTEIN C FOS; TRITIUM; UNCLASSIFIED DRUG;

ARTICLE; BINDING COMPETITION; CELL STRAIN HL 60; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; HUMAN; HUMAN CELL; PROTEIN EXPRESSION;

4-BUTYROLACTONE; BINDING, COMPETITIVE; CELL DIFFERENTIATION; CELL SURVIVAL; DINOPROSTONE; HL-60 CELLS; HUMANS; PROTO-ONCOGENE PROTEINS C-FOS; RADIOLIGAND ASSAY; RNA, MESSENGER; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TETRADECANOYLPHORBOL ACETATE;

EID: 0346333098     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm034216y     Document Type: Article

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