Simultaneous quantitative analysis of ketanserin and ketanserinol in plasma by RP-HPLC with fluorescence detection

Biomedical Chromatography

Volumn 17, Issue 8, 2003, Pages 517-521

  Yassen, A ^a   Hanff, L M ^a   Vulto, A G ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Dosage regimens; Neonate plasma level; Pre eclamptic; Pregnancy

Indexed keywords

CALIBRATION; EXTRACTION; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PHASE SEPARATION;

DOSAGE REGIMEN; FLUORESCENCE DETECTION; HUMAN PLASMAS; LIQUID CHROMATOGRAPHIC ASSAY; NEONATE PLASMA LEVEL; PERFORMANCE; PLASMA LEVELS; PRE-ECLAMPTIC; PREGNANCY; RP-HPLC;

PARTICLE SIZE;

ACETIC ACID; ACETONITRILE; BUFFER; KETANSERIN; KETANSERINOL; METHANOL;

ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STRUCTURE; FLUORESCENCE ANALYSIS; HUMAN; PARTICLE SIZE; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SENSITIVITY AND SPECIFICITY; STANDARD; VALIDATION PROCESS;

VIBRIO PHAGE NT-1;

EID: 0346258149     PISSN: 02693879     EISSN: None     Source Type: Journal    
DOI: 10.1002/bmc.265     Document Type: Article

References (11)

1. Bolte AC, van Geijn HP and Dekker GA. Pathophysiology of preeclampsia and the role of serotonin. European Journal of Obstetrics, Gynecology and Reprodive Biology 2001; 95(1): 12-21.
2. Davies CL. Determination of ketanserin in plasma by reversed-phase high-performance liquid chromatography. Journal of Chromatography 1983; 275(1): 232-233.
3. Duley L and Henderson-Smart DJ. Drugs for rapid treatment of very high blood pressure during pregnancy. Cochrane Database Systemic Review 2000; (2): CD001449.
4. Heykants J, Van Peer A, Woestenborghs R, Gould S and Mills J. Pharmacokinetics of ketanserin and its metabolite ketanserinol in man after intravenous, intramuscular and oral administration. European Journal of Clinical Pharmacology 1986; 31(3): 343-350.
5. Kacprowicz AT, Shaw PG, Moulds RF and Bury RW. Determination of ketanserin in human plasma by high-performance liquid chromatography. Journal of Chromatography 1983; 272(2): 417-420.
6. Kurowski M. Simultaneous determination of ketanserin and ketanserinol in biological fluids using ion-pair liquid chromatography and fluorometric detection. Journal of Chromatography 1985; 341(1): 208-212.
7. Lindelauf F. Determination of ketanserin and its major metabolite (reduced ketanserin) in human plasma by high-performance liquid chromatography. Journal of Chromatography 1983; 277: 396-400.
8. Okonkwo PO, Reimann IW, Woestenborghs R and Klotz U. High-performance liquid chromatographic assay with fluorometric detection of ketanserin, a new antihypertensive agent and serotonin S2 antagonist in human plasma, blood and urine. Journal of Chromatography 1983; 272(2): 411-416.
9. Persson B, Heykants J and Hedner T. Clinical pharmacokinetics of ketanserin. Clinical Pharmacokinetics 1991; 20(4): 263-279.
10. Simon V and Somani, P. Rapid method for determination of ketanserin, a novel antiserotonin drug, by high-performance liquid chromatography. Journal of Chromatography 1982; 232(1): 186-191.
11. van Schie DL, de Jeu RM, Steyn DW, Odendaal HJ and van Geijn HP. The optimal dosage of ketanserin for patients with severe hypertension in pregnancy. European Journal of Obstetrics, Gynecology and Reproductive Biology 2002; 102(2): 161-166.