Cow's milk antibodies in patients with newly diagnosed type 1 diabetes: Primary or secondary?

Pediatric Diabetes

Volumn 4, Issue 4, 2003, Pages 155-156

  Knip, Mikael ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

BOVINE SERUM ALBUMIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; MILK PROTEIN; PROTEIN ANTIBODY;

ANTIBODY DETECTION; ARTIFICIAL MILK; CHILD NUTRITION; DIABETOGENESIS; EDITORIAL; FOOD INTAKE; HUMAN; HUMORAL IMMUNITY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOLOGICAL TOLERANCE; IMMUNOREACTIVITY; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; INTESTINE MUCOSA PERMEABILITY; MILK; PATHOGENESIS; PRIORITY JOURNAL; RISK FACTOR;

ANIMALS; ANTIBODIES; CATTLE; DIABETES MELLITUS, TYPE 1; FEMALE; HUMANS; IMMUNOGLOBULIN G; MILK; MILK PROTEINS;

EID: 0346252500     PISSN: 1399543X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-543X.2003.00029.x     Document Type: Editorial

References (14)

1. Savilahti E, Åkerblom HK, Tainio VM, Koskimies S. Children with newly diagnosed insulin-dependent diabetes mellitus have increased levels of cow's milk antibodies. Diabetes Res 1988: 7: 137-140.
2. Savilahti E, Saukkonen TT, Virtala ET, Tuomilehto J, Åkerblom HK. Increased levels of cow's milk and β-lacto-globulin antibodies in young children with newly diagnosed IDDM. The Childhood Diabetes in Finland Study Group. Diabetes Care 1993: 16: 984-989.
3. Dahlquist G, Savilahti E, Landin-Olsson M. An increased level of antibodies to beta-lactoglobulin is a risk determinant for early-onset type 1 (insulin-dependent) diabetes mellitus independent of islet cell antibodies and early introduction of cow's milk. Diabetologia 1992: 35: 980-984.
4. Saukkonen T, Savilahti E, Vaarala O et al. Children with newly diagnosed IDDM have increased levels of antibodies to bovine serum albumin but not to ovalbumin. Diabetes Care 1994: 17: 970-976.
5. Levy-Marchal C, Karjalainen J, Dubois F, Karges W, Chernichow P, Dosch HM. Antibodies against bovine albumin and other diabetes markers in French children. Diabetes Care 1995: 18: 1089-1094.
6. Vaarala O, Knip M, Paronen J et al. Cow milk formula feeding induces primary immunization to insulin in infants at genetic risk for type 1 diabetes. Diabetes 1999: 48: 1389-1394.
7. Karjalainen J, Martin JM, Knip M et al. A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus. N Engl J Med 1992: 327: 302-307.
8. Atkinson MA, Bowman MA, Kao KJ et al. Lack of immune responsiveness to bovine serum albumin in insulin-dependent diabetes. N Engl J Med 1993: 329: 1853-1858.
9. Perez-Bravo F, Oyarzun A, Carrasco E, Albala C, Dorman JS, Santos JL. Duration of breast feeding and bovine serum albumin antibody levels in type 1 diabetes: a case-control study. Pediatr Diabetes 2003: 4: 157-161.
10. Verge CF, Howard NJ, Irwig L, Simpson JM, Mac Kerras D, Silink M. Environmental factors in childhood IDDM. A population-based case-control study. Diabetes Care 1994: 17: 1381-1389.
11. Virtanen SM, Hyppönen E, Läärä E et al. Cow's milk consumption, disease associated autoantibodies and type 1 diabetes mellitus: a follow-up study in siblings of diabetic children. Diabet Med 1998: 15: 730-738.
12. Vaarala O. The gut immune system and type 1 diabetes. Ann N Y Acad Sci 2002: 958: 39-46.
13. Kuitunen M, Saukkonen T, Ilonen J, Åkerblom HK, Savilahti E. Intestinal permeability to mannitol and lactulose in children with type 1 diabetes with the HLA-DQB1*02 allele. Autoimmunity 2002: 35: 365-368.
14. Virtanen SM, Saukkonen T, Savilahti E et al. Diet, cow's milk protein antibodies and the risk of IDDM in Finnish children. Diabetologia 1994: 37: 381-387.