Resistance to androstanes as an approach for androstandienedione yield enhancement in industrial mycobacteria

Journal of Industrial Microbiology and Biotechnology

Volumn 30, Issue 10, 2003, Pages 623-626

  Perez, Celso ^a   Falero, Alina ^a   Llanes, Nury ^a   Hung, Blanca R ^a   Hervé, Maria E ^a   Palmero, Alexis ^a   Martí, Elena ^a  

^a NATL CENTER FOR SCIENTIFIC RESEARCH   (Cuba)

Author keywords

Androstanes; Biotransformation; Mycobacteria; Steroids

Indexed keywords

1,4-ANDROSTADIENE-3,17-DIONE; ANDROSTANE DERIVATIVE; ANDROSTANEDIONE; BOLDIONE; NITROSOGUANIDINE; STEROID; STEROL; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM; BACTERIUM CULTURE; BACTERIUM MUTANT; BIOTRANSFORMATION; CULTURE MEDIUM; ENZYME ACTIVITY; FERMENTATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; METHODOLOGY; MICROBIOLOGY; MUTAGENESIS; MYCOBACTERIUM; NONHUMAN;

ANDROSTADIENES; ANDROSTANES; BACTERIA; BIOTRANSFORMATION; FERMENTATION; INDUSTRIAL MICROBIOLOGY; MUTAGENESIS; STEROLS;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); CORYNEBACTERINEAE; MYCOBACTERIUM; UNCULTURED ACTINOMYCETE;

EID: 0346249845     PISSN: 13675435     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10295-003-0079-4     Document Type: Article

References (18)

1. Ahmad S, Garg SK, Johri BN (1992) Biotransformation of sterols: selective cleavage of the side chains. Biotechnol Adv 10:1-67
2. Aniruda S, Patil S, Barti S (1992) Microbial conversion of solasodine to androstene-3,17-dione (AD), a key intermediate for androgene synthesis. Lett Appl Microbiol 15:86-88
3. 1-dehydogenase by Streptomyces lividans with a multi-copy shuttle vector. Appl Microbiol Biotechnol 43:1044-1049
4. Drake JW (1969) The molecular basis of mutation. HoldenDay, San Francisco
5. 1-dehydogenase from Rhodococcus rhodochrous. J Biochem 126:662-667
6. Hesselink P, de Vries H, Whitholt B (1987) Enhancement of microbial side chain cleavage by addition of cyclodextrin. In: Neijssel O, Van der Meers R, Luyben K (eds) Proceedings of the 4th European Congress of Biotechnology, vol 2. Elsevier, Amsterdam, pp 299-302
7. Hesselink P, van Vliet S, de Vries H, Witholt B (1989) Optimization of steroid side chain cleavage by Mycobacterium sp. in the presence of cyclodextrins. Enzyme Microb Technol 11:398-404
8. Hung BR, Falero A, Llanes N, Pérez C, Ramírez MA (1994) Testosterone as biotransformation product in steroid conversion by Mycobacterium sp. Biotechnol Lett 16:497-500
9. 1-dehydrogenase from Nocardia corallina. Biochim Biophys Acta 1040:281-286
10. Lee C-Y, Liu WH (1992). Production of androsta-1,4-diene3,17-dione from cholesterol using immobilized growing of Mycobacterium sp. NRRRL B-3683 adsorbed on solid carriers. Appl Microbiol Biotechnol 36:598-603
11. Mahato SB, Majundar I (1997) Current trends in microbial steroid biotransformation. Steroids 62:332-345
12. Martin CK (1977) Microbial cleavage of sterol side chain. Adv Appl Microbiol 22:29
13. Pérez C, Pérez I, Hervé ME (1995) Isolation and partial characterization of a new mutant for sterol biotransformation in Mycobacterium sp. Biotechnol Lett 17:1241-1246
14. Smith M, Zahnley J, Pfeifer D, Goff D (1993) Growth and cholesterol oxidation by Mycobacterium species in Tween 80 medium. Appl Environ Microbiol 59:1425-1429
15. Subramanyan VR, Pal BB, Mohanty KK (1989) Inducibility and stability of auxotrophic mutations in Mycobacterium fortuitum, M. smegmatis and M. vaccae. Lett Appl Microbiol 8:161-164
16. Wovcha MG, Antosz FJ, Knight JC, Kominek LA, Pike TR (1978) Bioconversion of sitosterol to useful steroidal intermediates by mutants of Mycobacterium fortuitum. Biochim Biophys Acta 531:308-321
17. Wovcha MG, Brooks KE, Kominek LA (1979) Evidence for two steroid 1,2 dehydrogenase activities in Mycobacterium fortuitum. Biochim Biophys Acta 574:471-479
18. Zeillinger R, Spona J (1986) Pseudomonas testosteroni: new data about growth and steroid metabolism. FEMS Microbiol Lett 37:231-235