Innovation and placebos in research: A new design of clinical trial

Lancet

Volumn 362, Issue 9401, 2003, Pages 2036-2037

  Holbrook, Anne ^a,b   Goldsmith, Charles ^a,b  

^a CENTRE FOR EVALUATION OF MEDICINES   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; PLACEBO;

CALCULATION; CLINICAL RESEARCH; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG RESEARCH; HUMAN; MEDICAL RESEARCH; METHODOLOGY; NOTE; PATIENT SELECTION; PRIORITY JOURNAL; RANDOMIZATION;

EID: 0346157335     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(03)15147-1     Document Type: Note

References (10)

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2. Charney D.S., Nemeroff C.B., Lewis L., et al. National Depressive and Manic-Depressive Association consensus statement on the use of placebo in clinical trials of mood disorders. Arch Gen Psychiatry. 59:2002;262-270.
3. Feinstein A.R. Post-therapeutic response and therapeutic "style": re-formulating the "placebo effect" J Clin Epidemiol. 55:2002;427-429.
4. Emanuel E.J., Miller F.G. The ethics of placebo-controlled trial - a middle ground. N Engl J Med. 345:2001;915-919.
5. Amdur R.J., Biddle C.J. An algorithm for evaluating the ethics of a placebo-controlled trial. Int J Cancer. 96:2001;261-269.
6. Huston P., Peterson R. Withholding proven treatment in clinical research. N Engl J Med. 345:2001;912-914.
7. Weijer C. Placebo trials and tribulations. CMAJ. 166:2002;603-604.
8. Fava M., Evins A.E., Dorer D.J., Schoenfeld D.A. The problem of the placebo response in clinical trials for psychiatric disorders: culprits, possible remedies, and a novel study design approach. Psychother Psychosom. 72:2003;115-127.
9. Walsh B.T., Seidman S.N., Sysko R., Gould M. Placebo response in studies of major depression: variable, substantial, and growing. JAMA. 287:2002;1840-1847.
10. Goldsmith CH. Efficacy designs when a placebo group is unethical. Joint Statistical Meetings, New York, Aug 14, 2002: 282 (abstr 301763).