Efficient One-Step Syntheses of Isoprenoid Conjugates of Nucleoside 5′-Diphosphates

Organic Letters

Volumn 5, Issue 24, 2003, Pages 4713-4715

  Ryu, Youngha ^a   Scott, A Ian ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORIDE; ISOPRENE; ISOPRENOID; NUCLEOSIDE DERIVATIVE; PYROPHOSPHORIC ACID DERIVATIVE; TOLUENESULFONIC ACID DERIVATIVE;

ARTICLE; CONJUGATE; DRUG STRUCTURE; DRUG SYNTHESIS;

MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; NUCLEOTIDES; POLYISOPRENYL PHOSPHATES;

EID: 0346150263     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol035880b     Document Type: Article

References (15)

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12. The literature indicates that alkylation reagents such as alkyl halides, diakyl sulfates and trialkyl phosphates led to nonselective multi-akylation on both nucleoside bases and phosphates. For examples, see: (a) Ogilvie, K. K.; Beaucage, S. L.; Gillen, M. F.; Entwistle, D. W. Nucleic Acids Res. 1979, 6, 2261. (b) Ogilvie, K. K.; Beaucage, S. L.; Gillen, M. F.; Entwistle, D.; Quilliam, M. Nucleic Acids Res. 1979, 6, 1695.
13. The literature indicates that alkylation reagents such as alkyl halides, diakyl sulfates and trialkyl phosphates led to nonselective multi-akylation on both nucleoside bases and phosphates. For examples, see: (a) Ogilvie, K. K.; Beaucage, S. L.; Gillen, M. F.; Entwistle, D. W. Nucleic Acids Res. 1979, 6, 2261. (b) Ogilvie, K. K.; Beaucage, S. L.; Gillen, M. F.; Entwistle, D.; Quilliam, M. Nucleic Acids Res. 1979, 6, 1695.
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15. Unpublished result and personal communication from Dr. J. W. Szostak and Dr. B. Seelig.