The effect of an elevated maternal lysine concentration on placental lysine transport in pregnant sheep

American Journal of Obstetrics and Gynecology

Volumn 189, Issue 5, 2003, Pages 1494-1500

  Wilkes, Paul T ^a   Meschia, Giacomo ^a   Teng, Cecilia ^a   Zhu, Yaming ^a   Wilkening, Randall B ^a   Battaglia, Frederick C ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b Building 260 ^*  (United States)

Author keywords

Essential amino acids; Fetal growth; Nutrition; Placental transport; Uterine and umbilical lysine uptake

Indexed keywords

2 AMINOADIPIC ACID; AMINO ACID; LYSINE;

ANIMAL EXPERIMENT; ARTICLE; CIRCULATION; CONTROLLED STUDY; DIFFUSION; FEMALE; FETUS GROWTH; NONHUMAN; NUTRITION; PLACENTA; PREGNANCY; PRIORITY JOURNAL; SHEEP; UMBILICAL CORD BLOOD FLOW; UMBILICAL VEIN; UMBILICUS; UTERINE BLOOD VESSEL; VEIN;

EID: 0346120402     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1067/S0002-9378(03)00595-7     Document Type: Article

References (19)

1. Jóźwik M, Teng C, Timmerman M, Chung M, Meschia G, Battaglia FC. Uptake and transport by the ovine placenta of neutral nonmetabolizable amino acids with different transport system affinities. Placenta 1998;19:531-8.
2. Smith CH, Moe AJ, Ganapathy V. Nutrient transport pathways across the epithelium of the placenta. Annu Rev Nutr 1992;12:183-206.
3. Moe AJ. Placental amino acid transport. Am J Physiol 1995;268: C1321-C1331.
4. Jóźwik M, Teng C, Wilkening RB, Meschia G, Tooze J, Chung M, et al. Effects of branched chain amino acids on placental amino acid transfer and insulin and glucagons release in the ovine fetus. Am J Obstet Gynecol 2001;185:487-95.
5. Paolini CL, Meschia G, Fennessey P, Pike AP, Teng C, Battaglia FC, et al. An in vivo study of ovine placental transport of essential amino acids. Am J Physiol Endocrinol Metab 2001;280:E31-9.
6. Ross JR, Fennessey PV, Wilkening RB, Battaglia FC, Meschia G. Placental transport and fetal utilization of leucine in a model of fetal growth retardation. Am J Physiol Endocrinol Metab 1996;270: E491-503.
7. 2 kinetics. J Dev Physiol 1984;6:359-62.
8. Chung M, Teng C, Timmerman M, Meschia G, Battaglia FC. Production and utilization of amino acids by ovine placenta in vivo. Am J Physiol 1998;274:E13-22.
9. Anderson AH, Fennessey PV, Meschia G, Wilkening RB, Battaglia FC. Placental transport of threonine and its utilization in the normal and growth-restricted fetus. Am. J Physiol Endocrinol Metab 1997;272: E892-900.
10. Kudo Y, Boyd CAR. Human placental amino acid transporter genes: expression and function. Reproduction 2002;124:595-600.
11. Vaughn PR, Lobo C, Battaglia FC, Fennessey PV, Wilkening RB, Meschia G. Glutamine-glutamate exchange between placenta and fetal liver. Am J Physiol Endocrinol Metab 1995;268:E705-11.
12. Polonsky KS, O'Meara NM. Secretion and metabolism of insulin, proinsulin and C peptide. In: DeGroot J, Jameson JL, editors. Endocrinology. 4th ed. Philadelphia: WB Saunders; 2001. p. 697-711.
13. Meier PR, Peterson RG, Bonds DR, Meschia G, Battaglia FC. Rates of protein synthesis and turnover in fetal life. Am J Physiol Endocrinol Metab 3 1981;240:E320-4.
14. Teng C, Battaglia FC, Meschia G, Narkewicz M, Wilkening RB. Fetal hepatic and umbilical uptakes of glucogenic substrates before and during a glucagon-somatostatin infusion. Am J Physiol Endocrinol Metab 2002;282:E542-50.
15. Tsui B, Dennehy CE, Tsourounis C. A survey of dietary supplement use during pregnancy at an academic medical center. Am J Obstet Gynecol 2001;185:433-7.
16. Bajoria R, Sooranna SR, Ward S, D'Souza S, Hancock M. Placental transport rather than maternal concentration of amino acids regulates fetal growth in monochorionic twins: implications for fetal origin hypothesis. Am J Obstet Gynecol 2001;185:1239-46.
17. Cetin I, Ronzoni S, Marconi AM, Perugino G, Corbetta C, Battaglia FC, et al. Maternal concentrations and fetal-maternal concentration differences of plasma amino acids in normal and intrauterine growth-restricted pregnancies. Am J Obstet Gynecol 1996;174:1575-83.
18. Ronzoni S, Marconi AM, Cetin I, Paolini CL, Teng C, Pardi G, et al. Umbilical amino acid uptake at increasing maternal amino acid concentrations: effect of a maternal amino acid infusate. Am J Obstet Gynecol 1999;181:477-83.
19. Harding JE, Charlton V. Treatment of the growth retarded fetus by augmentation of substrate supply. Semin Perinatol 1989;13: 211-23.