Functional specificity of two hormone response elements present on the human apoA-II promoter that bind retinoid X receptor α/thyroid receptor β heterodimers for retinoids and thyroids: Synergistic interactions between thyroid receptor β and upstream stimulatory factor 2a

Biochemical Journal

Volumn 376, Issue 2, 2003, Pages 423-431

  Hatzivassiliou, Eudoxia ^a   Koukos, George ^b   Ribeiro, Agnes ^c   Zannis, Vassilis ^b,d   Kardassis, Dimitris ^b  

^a BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING   (Greece)

^b UNIVERSITY OF CRETE   (Greece)

^c INSERM   (France)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apolipoprotein; Atherosclerosis; Gene regulation; Hormone nuclear receptor; Thyroid hormone responsive element; Transcriptional synergism

Indexed keywords

DIMERS; DNA; MUTAGENESIS;

TRANSCRIPTION FACTORS;

HORMONES;

ALITRETINOIN; APOLIPOPROTEIN A2; HYBRID PROTEIN; LIOTHYRONINE; RETINOID; RETINOID X RECEPTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CERCOPITHECIDAE; ELECTROPHORETIC MOBILITY; EMBRYO; GENE CONTROL; HORMONE RESPONSIVE ELEMENT; HUMAN; HUMAN CELL; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING;

ANIMALS; APOLIPOPROTEIN A-II; BINDING SITES; CELL LINE; COS CELLS; DIMERIZATION; DNA-BINDING PROTEINS; DRUG SYNERGISM; HUMANS; MODELS, BIOLOGICAL; PROMOTER REGIONS (GENETICS); RECEPTORS, RETINOIC ACID; RESPONSE ELEMENTS; RETINOID X RECEPTORS; THYROID HORMONE RECEPTORS BETA; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRETINOIN; TRIGLYCERIDES; TRIIODOTHYRONINE; UPSTREAM STIMULATORY FACTORS;

ANIMALIA; CERCOPITHECIDAE; HOMO;

EID: 0346103825     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20030549     Document Type: Article

References (40)

1. Schonfeld, G., Patsch, W., Rudel, L. L., Nelson, C., Epstein, M. and Olson, R. E. (1982) Effects of dietary cholesterol and fatty acids on plasma lipoproteins. J. Clin. Invest. 69, 1072-1080
2. Brewer, Jr, H. B., Lux, S. E., Ronan, R. and John, K. M. (1972) Amino acid sequence of human apoLp-Gln-II (apoA-II), an apolipoprotein isolated from the high-density lipoprotein complex. Proc. Natl. Acad. Sci. U.S.A. 69, 1304-1308
3. Lusis, A. J. (1988) Genetic factors affecting blood lipoproteins: the candidate gene approach. J. Lipid Res. 29, 397-428
4. Doolittle, M. H., LeBoeuf, R. C., Warden, C. H., Bee, L. M. and Lusis, A. J. (1990) A polymorphism affecting apolipoprotein A-II translational efficiency determines high density lipoprotein size and composition. J. Biol. Chem. 265, 16380-16388
5. Warden, C. H., Hedrick, C. C., Qiao, J. H., Castellani, L. W. and Lusis, A. J. (1993) Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II. Science 261, 469-472
6. Warden, C. H., Bu, X., Dalinski, A., Purcell-Huynh, D. A., DeMeester, C., Shieh, B.-H., Puppione, D. L., Gray, R. M., Reaveau, G. M., Chen, Y.-D. I. et al. (1993) A multivariate metabolic phenotype is linked to the apolipoprotein A-II gene in both mice and man: synteny at the ath-1 locus. Circulation 88 (Suppl.), 1429
7. Schultz, J. R., Verstuyft, J. G., Gong, E. L., Nichols, A. V. and Rubin, E. M. (1993) Protein composition determines the anti-atherogenic properties of HDL in transgenic mice. Nature (London) 365, 762-764
8. Tailleux, A., Bouly, M., Luc, G., Castro, G., Caillaud, J. M., Hennuyer, N., Poulain, P., Fruchart, J. C., Duverger, N. and Fievet, C. (2000) Decreased susceptibility to diet-induced atherosclerosis in human apolipoprotein A-II transgenic mice. Arterioscler., Thromb., Vasc. Biol. 20, 2453-2458
9. Boisfer, E., Lambert, G., Atger, V., Tran, Q. N., Pastier, D., Benetollo, C., Trottier, J. F., Beaucamps, I., Antonucci, M., Laplaud, M. et al. (1999) Overexpression of human apolipoprotein A-II in mice induces hypertriglyceridemia due to defective VLDL hydrolysis. J. Biol. Chem 274, 11564-11572
10. Hussain, M. M. and Zannis, V. I. (1990) Intracellular modification of human apolipoprotein AII (apoA-II) and sites of apoA-II mRNA synthesis: comparison of apoA-II with apoCIII and apoCIII isoproteins. Biochemistry 29, 209-217
11. Kardassis, D., Laccotripe, M., Talianidis, I. and Zannis, V. I. (1996) Transcriptional regulation of the genes involved in lipoprotein transport. The role of proximal promoters and long range regulatory elements and factors in apolipoprotein gene region. Hypertension 27, 980-1008
12. Chambaz, J., Cardot, P., Pastier, D., Zannis, V. and Cladaras, C. (1991) Promoter elements and factors required for hepatic transcription of the human apoA-II gene. J. Biol. Chem. 266, 11676-11685
13. Zannis, V. I., Kan, H. Y., Kritis, A., Zanni, E. E. and Kardassis, D. (2001) Transcriptional regulation of the human apolipoprotein genes. Front Biosci. 6, D456-D504
14. Cardot, P., Chambaz, J., Kardassis, D., Cladaras, C. and Zannis, V. I. (1993) Factors participating in the liver-specific expression of the human apolipoprotein A-II gene and their significance for transcription. Biochemistry 32, 9080-9093
15. Lacorte, J. M., Fourniat, E., Pastier, D., Chambaz, J., Ribeiro, A. and Cardot, P. (1996) The proximal element of the human apolipoprotein A-II promoter increases the enhancer activity of the distal region. Biochem. J. 318, 681-688
16. Cardot, P., Chambaz, J., Cladaras, C. and Zannis, V. I. (1991) Regulation of the human apoA-II gene by the synergistic action of factors binding to the proximal and distal regulatory elements. J. Biol. Chem. 266, 24460-24470
17. Sawadogo, M. and Roeder, R. G. (1985) Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region. Cell (Cambridge, Mass.) 43, 165-175
18. Ribeiro, A., Pastier, D., Kardassis, D., Chambaz, J. and Cardot, P. (1999) Cooperative binding of upstream stimulatory factor and hepatic nuclear factor 4 drives the transcription of the human apolipoprotein A-II gene. J. Biol. Chem. 274, 1216-1225
19. Pissios, P., Kan, H. Y., Nagaoka, S. and Zannis, V. I. (1999) SREBP-1 binds to multiple sites and transactivates the human apoA-II promoter in vitro: SREBP-1 mutants defective in DNA binding or transcriptional activation repress the apoA-II promoter activity. Arterioscler., Thromb., Vasc. Biol. 19, 1456-1469
20. Kan, H. Y., Pissios, P., Chambaz, J. and Zannis, V. I. (1999) DNA binding specificity and transactivation properties of SREBP-2 bound to multiple sites on the human apoA-II promoter. Nucleic Acids Res. 27, 1104-1117
21. Ladias, J. A. A., Hadzopoulou-Cladaras, M., Kardassis, D., Cardot, P., Cheng, J., Zannis, V. I. and Cladaras, C. (1992) Transcriptional regulation of human apolipoprotein genes ApoB, ApoCIII, and ApoAII by members of the steroid hormone receptor superfamily HNF-4, ARP-1, EAR-2, and EAR-3. J. Biol. Chem. 267, 15849-15860
22. Vu-Dac, N., Schoonjans, K., Kosykh, V., Dallongeville, J., Heyman, R. A., Staels, B. and Auwerx, J. (1996) Retinoids increase human apolipoprotein A-II expression through activation of the retinoid X receptor but not the retinoic acid receptor. Mol. Cell. Biol. 16, 3350-3360
23. Hatzivassiliou, E., Cardot, P., Zannis, V. I. and Mitsialis, S. A. (1997) Ultraspiracle, a Drosophila retinoic X receptor α homologue, can mobilize the human thyroid hormone receptor to transactivate a human promoter. Biochemistry 36, 9221-9231
24. Lavrentiadou, S. N., Hadzopoulou-Cladaras, M., Kardassis, D. and Zannis, V. I. (1999) Binding specificity and modulation of the human ApoCIII promoter activity by heterodimers of ligand-dependent nuclear receptors. Biochemistry 38, 964-975
25. Graham, F. L. and van der Eb, A. J. (1973) A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52, 456-467
26. Gorman, C. M., Moffat, L. F. and Howard, B. H. (1982) Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2, 1044-1051
27. Edlund, T., Walker, M. D., Barr, P. J. and Rutter, W. J. (1985) Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5′-flanking elements. Science 30, 912-916
28. Kardassis, D., Zannis, V. I. and Cladaras, C. (1992) Organization of the regulatory elements and nuclear activities participating in the transcription of the human apolipoprotein B gene. J. Biol. Chem. 267, 2622-2632
29. Shih, H.-M., Liu, Z. and Towle, H. C. (1995) Two CACGTG motifs with proper spacing dictate the carbohydrate regulation of hepatic gene transcription. J. Biol. Chem. 270, 21991-21997
30. Sawadogo, M. (1988) Multiple forms of the human gene-specific transcription factor USF. II. DNA binding properties and transcriptional activity of the purified HeLa USF. J. Biol. Chem. 263, 11994-12001
31. Sirito, M., Lin, Q., Marity, T. and Sawadogo, M. (1994) Ubiquitous expression of the 43- and 44-kDa forms of transcription factor USF in mammalian cells. Nucleic Acids Res. 22, 427-433
32. Viollet, B., Lefrançois-Martinez, A.-M., Henrion, A., Khan, A., Raymondjean, M. and Martinez, A. (1996) Immunochemical characterization and transacting properties of upstream stimulatory factor isoforms. J. Biol. Chem. 271, 1405-1415
33. Henrion, A. A., Martinez, A., Mattei, M.-G., Khan, A. and Raymondjean, M. (1995) Structure, sequence, and chromosomal location of the gene for USF2 transcription factors in mouse. Genomics 25, 36-43
34. Moras, D. and Gronemeyer, H. (1998) The nuclear receptor ligand-binding domain: structure and function. Curr. Opin. Cell Biol. 10, 384-391
35. Breen, G. A. and Jordan, E. M. (1999) Transcriptional activation of the F(1)F(0) ATP synthase α-subunit initiator element by USF2 is mediated by p300. Biochim. Biophys. Acta 1428, 169-176
36. Moore, M. L., Park, E. A. and McMillin, J. B. (2003) Upstream stimulatory factor represses the induction of carnitine palmitoyltransferase- 1β expression by PGC-1. J. Biol. Chem. 278, 17263-17268
37. Xing, W. and Archer, T. K. (1998) Upstream stimulatory factors mediate estrogen receptor activation of the cathepsin D promoter. Mol. Endocrinol. 12, 1310-1321
38. Strobl, W., Chan, L. and Patsch, W. (1992) Differential regulation of hepatic apolipoprotein A-I and A-II gene expression by thyroid hormone in rat liver. Atherosclerosis 97, 161-170
39. Davidson, N. O., Carlos, R. C., Drwerk, M. J. and Parmer, T. G. (1988) Apolipoprotein gene expression in the rat is regulated in a tissue-specific manner by thyroid hormone. J. Lipid Res. 29, 1511-1522
40. Lin-Lee, Y.-C., Strobl, W., Soyal, S., Radosavljevic, M., Song, M., Gotto, Jr, A. M. and Patsch, W. (1992) Role of thyroid hormone in the expression of apolipoprotein A-IV and C-III genes in rat liver. J. Lipid Res. 34, 249-259