Induction Chemotherapy followed by Concomitant TFHX Chemoradiotherapy with Reduced Dose Radiation in Advanced Head and Neck Cancer

Clinical Cancer Research

Volumn 9, Issue 16 I, 2003, Pages 5936-5943

  Haraf, Daniel J ^a,e   Rosen, Fred R ^d   Stenson, Kerstin ^a   Argiris, Athanassios ^b,c   Mittal, Bharat B ^b,c   Witt, Mary Ellyn ^a   Brockstein, Bruce E ^b,c   List, Marcy A ^a   Portugal, Louis ^e   Pelzer, Harold ^c   Weichselbaum, Ralph R ^a,e   Vokes, Everett E ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d UNIVERSITY OF ILLINOIS   (United States)

^e UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOPLATIN; FLUOROURACIL; HYDROXYUREA; PACLITAXEL;

ADULT; ADVANCED CANCER; AGED; ALOPECIA; ANOREXIA; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER CONTROL; CANCER RADIOTHERAPY; CANCER SURVIVAL; COHORT ANALYSIS; CONSTIPATION; DIARRHEA; FATIGUE; FEMALE; FEVER; HEAD AND NECK CANCER; HIGH RISK PATIENT; HUMAN; INFECTION; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; NAUSEA; NEUROPATHY; PAIN; PRIORITY JOURNAL; QUALITY OF LIFE; RADIATION DOSE; SIDE EFFECT; VOMITING;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARBOPLATIN; CARCINOMA, SQUAMOUS CELL; COHORT STUDIES; COMBINED MODALITY THERAPY; DISEASE PROGRESSION; DISEASE-FREE SURVIVAL; FEMALE; FLUOROURACIL; HEAD AND NECK NEOPLASMS; HUMANS; HYDROXYUREA; MALE; MIDDLE AGED; PACLITAXEL; QUALITY OF LIFE; RADIOTHERAPY DOSAGE; REMISSION INDUCTION; SURVIVAL RATE;

EID: 0346103804     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Forastiere, A., Koch, W., Trotti, A., and Sidransky, D. Head and neck cancer. N. Engl. J. Med., 345: 1890-1900, 2001.
2. Lamont, E., and Vokes, E. E. Chemotherapy in the management of squamous cell carcinoma of the head and neck. Lancet Oncol., 2: 261-269, 2001.
3. El-Sayed, S., and Nelson, N. Adjuvant and adjunctive chemotherapy in the management of squamous cell carcinoma of the head and neck region. A meta-analysis of prospective and randomized trials. J. Clin. Oncol., 14: 838-847, 1996.
4. Pignon, J. P., Bourhis, J., Domenge, C., and Designe, L. Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer. Lancet, 355: 949-955, 2000.
5. Wendt, T., Grabenbauer, G., Rodel, C., Thiel, H. J., Aydin, H., Rohloff, R., Wustrow, T. P., Iro, H., Popella, C., and Schalhorn, A. Simultaneous radiochemotherapy versus radiotherapy alone in advanced head and neck cancer: a randomized multicenter study. J. Clin. Oncol., 16: 1318-1324, 1998.
6. Brizel, D. M., Albers, M. E., Fisher, S. R., Scher, R. L., Richtsmeier, W. J., Hars, V., George, S. L., Huang, A. T., and Prosnitz, L. R. Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer [see comments]. N. Engl. J. Med., 338: 1798-1804, 1998.
7. Jeremic, B., Shibamoto, Y., Milicic, B., Nikolic, N., Dagovic, A., Aleksandrovic, J., Vaskovic, Z., and Tadic, L. Hyperfractionated radiation therapy with or without concurrent low-dose daily cisplatin in locally advanced squamous cell carcinoma of the head and neck: a prospective randomized trial. J. Clin. Oncol., 18: 1458-1464, 2000.
8. Calais, G., Alfonsi, M., Bardet, E., Sire, C., Germain, T., Bergerot, P., Rhein, B., Tortochaux, J., Oudinot, P., and Bertrand, P. Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma [see comments]. J. Natl. Cancer Inst. (Bethesda), 91: 2081-2086, 1999.
9. Forastiere, A., Berkey, B., Maor, M., Weber, R., Goepfert, H., Morrison, W. H., Glosson, B. S., Trotti, A., Ridge, J. A., Chao, C., Peters, G., Lee, D., Leaf, A., and Ensley, J. Phase III trial to preserve the larynx: induction chemotherapy and radiotherapy versus concomitant chemoradiotherapy versus radiotherapy alone, Intergroup Trial R91-11. Proc. Am. Soc. Clin. Oncol. 20: 2a, 2001.
10. Adelstein, D. J., Li, Y., Adams, G. L., Wagner, H., Jr., Kish, J. A., Ensley, J. F., Schul, D. E., and Forastiere, A. A. An Intergroup Phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J. Clin. Oncol., 21: 92-98, 2003.
11. Adelstein, D. L., Lavertu, P., Saxton, J. P., Secic, M., Wood, B. G., Wanamaker, J. R., Eliachar, I., Strome, M., and Larto, M. A. Mature results of a Phase III randomized trial comparing concurrent chemoradiotherapy with radiation therapy alone in patients with stage III and IV squamous cell carcinoma of the head and neck. Cancer (Phila.), 88: 876-883, 2000.
12. Vokes, E. E., and Athanasiadis, I. Chemotherapy of squamous cell carcinoma of head and neck: the future is now. Ann. Oncol., 7: 15-29, 1996.
13. Adelstein, D. Induction chemotherapy in head and neck cancer. Hematol. Oncol. Clin. N. Am., 13: 689-698, v-vi, 1999.
14. Paccagnella, A., Orlando, A., Marchiori, C., Zorat, P. L., Cavaniglia, G., Sileni, V. C., Jirillo, A., Tomio, L., Fila, G., Fede, A., et al. Phase III trial of initial chemotherapy in stage III or IV head and neck cancers: a study by the Gruppo di Studio sui Tumori della Testa e del Collo. J. Natl. Cancer Inst. (Bethesda), 86: 265-272, 1994.
15. Domenge, C., Hill, C., Lefebvre, J. L., De Raucourt, D., Rhein, B., Wibault, P., Marandas, P., Coche-Dequeant, B., Stromboni-Luboinski, M., Sancho-Garnier, H., Luboinski, B., and the French Groupe d'Etude des Tumeurs de la Tete et du Cou (GETTEC). Randomized trial of neoadjuvant chemotherapy in oropharyngeal carcinoma. French Groupe d'Etude des Tumeurs de la Tete at du Cou (GETTEC). Br. J. Cancer, 83: 1594-1598, 2000.
16. Lefebvre, J. L., Chevalier, D., Luboinski, B., Kirkpatrick, A., Collette, L., and Sahmoud, T. Larynx preservation in pyriform sinus cancer: preliminary results of a European Organization for Research and Treatment of Cancer Phase III trial. EORTC Head and Neck Cancer Cooperative Group [see comments]. J. Natl. Cancer Inst. (Bethesda), 88: 890-899, 1996.
17. Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. The Department of Veterans Affairs Laryngeal Cancer Study Group [see comments]. N. Engl. J. Med. 324: 1685-1690, 1991.
18. Vokes, E. E., Kies, M., Haraf, D. J., Mick, R., Moran, W. J., Kozloff, M., Mittal, B., Pelzer, H., Wenig, B., Panje, W., et al. Induction chemotherapy followed by concomitant chemoradiotherapy for advanced head and neck cancer: impact on the natural history of the disease. J. Clin. Oncol., 13: 876-883, 1995.
19. Kies, M., Haraf, D., Athanasiadis, I., Kozloff, M., Mittal, B., Pelzer, H., Rademaker, A. W., Wenig, B., Weichselbaum, R. R., and Vokes, E. E. Induction chemotherapy followed by concurrent chemoradiation for advanced head and neck cancer: improved disease control and survival. J. Clin. Oncol., 16: 2715-2721, 1998.
20. Vokes, E. E., Kies, M. S., Haraf, D. J., Stenson, K., List, M., Humerickhouse, R., Dolan, M. E., Pelzer, H., Sulzen, L., Witt, M. E., Hsieh, Y. C., Mittal, B. B., and Weichselbaum, R. R. Concomitant chemoradiotherapy as primary therapy for locoregionally advanced head and neck cancer. J. Clin. Oncol., 18: 1652-1661, 2000.
21. Kies, M. S., Haraf, D. J., Rosen, F., Stenson, K., List, M., Brockstein, B., Chung, T., Mittal, B. B., Pelzer, H., Portugal, L., Rademaker, A., Weichselbaum, R., and Vokes, E. E. Concomitant infusional paclitaxel and fluorouracil, oral hydroxyurea, and hyperfractionated radiation for locally advanced squamous head and neck cancer. J. Clin. Oncol., 19: 1961-1969, 2001.
22. Rosen, F. R., Haraf, D. J., Kies, M. S., Portugal, L., List, M., Brockstein, B., Chung, T., Mittal, B. B., Stenson, K., Pelzer, H., Rademaker, A., Weichselbaum, R., and Vokes, E. E. Multicenter randomized Phase II study of paclitaxel (1 hour infusion), fluorouracil, hydroxyurea and concomitant hyperfractionated radiation with or without erythropoietin for advanced oral, pharynx and larynx cancer. Clin. Cancer Res., 9:1689-1697, 2003.
23. Vokes, E. E., Stenson, K., Rosen, F. R., Kies, M. S., Rademaker, A. W., Witt, M. E., Brockstein, B. E., List, M. A., Fung, B. B., Portugal, L., Mittal, B. B., Pelzer, H., Weichselbaum, R. R., and Haraf, D. J. Weekly carboplatin and paclitaxel followed by concomitant paclitaxel, fluorouracil, and hydroxyurea chemoradiotherapy: curative and organ-preserving therapy for advanced head and neck cancer. J. Clin. Oncol., 21: 320-326, 2003.
24. Adelstein, D. J., Saxton, J. P., Lavertu, P., Rybicki, L. A., Esclamado, R. M., Wood, B. G., Strome, M., and Carroll, M. A. Maximizing local control and organ preservation in stage IV squamous cell head and neck cancer with hyperfractionated radiation and concurrent chemotherapy. J. Clin. Oncol., 20: 1405-1410, 2002.
25. Kumar, P., and Robbins, K. T. Treatment of advanced head and neck cancer with intra-arterial cisplatin and concurrent radiation therapy: the 'RADPLAT' protocol. Curr. Oncol. Rep., 3: 59-65, 2001.
26. Zeman, E. M. Biologic basis of radiation oncology. In: L. L. Gunderson and J. E. Tepper (eds), Clinical Radiation Oncology, pp. 1-41. New York: Churchill Livingstone, 2000.
27. Maciejewski, B., Preuss-Bayer, G., and Trott, K. R. The influence of the number of fractions and of overall treatment time on local control and late complication rate in squamous cell carcinoma of the larynx. Int. J. Radiat. Oncol. Biol. Phys., 9: 321-328, 1983.
28. Fu, K. K., Pajak, T. F., Marvial, V. A., Ortiz, H. G., Rotman, M., Asbell, S. O., Coia, L. R., Vora, N. L., Byhardt, R., Rubin, P., Sorgen, S. D., Cox, J. D., and Stetz, J. Late effects of hyperfractionated radiotherapy for advanced head and neck cancer: long-term follow-up results of RTOG 83-13. Int. J. Radiat. Oncol. Biol. Phys., 32: 577-588, 1995.
29. Taylor, J. M., Mendenhall, W. M., and Lavey, R. S. Dose, time and fraction size issues for late effects in head and neck cancers. Int. J. Radiat. Oncol. Biol. Phys., 22: 3-11, 1992.
30. Brockstein, B., Haraf, D. J., Stenson, K., Fasanmade, A., Stupp, R., Glisson, B., Lippman, S. M., Ratain, M. J., Sulzen, L., Klepsch, A., Weichselbaum, R. R., and Vokes, E. E. Phase I study of concomitant chemoradiotherapy with paclitaxel, fluorouracil, and hydroxyurea with granulocyte colony-stimulating factor support for patients with poor-prognosis cancer of the head and neck. J. Clin. Oncol., 16: 735-744, 1998.
31. Brockstein, B., Haraf, D. J., Stenson, K., Sulzen, L., Witt, M. E., Weichselbaum, R. W., and Vokes, E. E. A Phase I-II study of concomitant chemoradiotherapy with paclitaxel (one-hour infusion), 5-fluorouracil and hydroxyurea with granulocyte colony stimulating factor support for patients with poor prognosis head and neck cancer. Ann. Oncol., 11: 721-728, 2000.
32. List, M. A., Siston, A., Haraf, D., Schumm, P., Kies, M., Stenson, K., and Vokes, E. E. Quality of life and performance in advanced head and neck cancer patients on concomitant chemoradiotherapy: a prospective examination. J. Clin. Oncol., 17: 1020-1028, 1999.
33. Cella, D. F., Tulsky, D. S., Gray, G., Sarafian, B., Linn, E., Bonomi, A., Silberman, M., Yellen, S. B., Winicour, P., Brannon, J., et al. The Functional Assessment of Cancer Therapy scale: development and validation of the general measure. J. Clin. Oncol., 11: 570-579, 1993.
34. List, M. A., Ritter-Sterr, C., and Lansky, S. B. A performance status scale for head and neck cancer patients. Cancer (Phila.), 66: 564-569, 1990.
35. List, M. A., D'Antonio, L. L., Cella, D. F., Siston, A., Mumby, P., Haraf, D., and Vokes, E. The performance status scale for head and neck cancer patients and the functional assessment of cancer therapy-head and neck scale. A study of utility and validity. Cancer (Phila.), 77: 2294-2301, 1996.
36. Browman, G. P., Levine, M. N., Hodson, D. I., Sathya, J., Russell, R., Skingley, P., Cripps, C., Eapen, L., and Girard, A. The Head and Neck Radiotherapy Questionnaire: a morbidity/quality-of-life instrument for clinical trials of radiation therapy in locally advanced head and neck cancer. J. Clin. Oncol., 11: 863-872, 1993.
37. Radloff, L. The CES-D scale: a self-report depression scale for research in the general population. Appl. Psychol. Meas., 3: 385-401, 1977.
38. Stenson, K. M., Haraf, D. J., Pelzer, H., Recant, W., Kies, M. S., Weichselbaum, R. R., and Vokes, E. E. The role of cervical lymphadenopathy after aggressive concomitant chemoradiotherapy: the feasibility of selective neck dissection. Arch. Otolaryngol. Head Neck Surg., 126: 950-956, 2000.