Induction of apoptosis by p53, bax, bcl-2, and p21 expressed in colorectal cancer

International Journal of Clinical Oncology

Volumn 8, Issue 6, 2003, Pages 352-356

  Katsumata, Kenji ^a,b   Sumi, Tetsuo ^a   Tomioka, Haenori ^a   Aoki, Tatsuya ^a   Koyanagi, Yasuhisa ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

^b Makino Memorial Hospital   (Japan)

Author keywords

Apoptosis; bax; bcl 2; Colorectal cancer; p21; p53

Indexed keywords

DNA; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53;

ADULT; AGED; APOPTOSIS; ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; CORRELATION COEFFICIENT; DNA SEQUENCE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; NICK END LABELING; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE STRAND CONFORMATION POLYMORPHISM;

AGED; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; COLORECTAL NEOPLASMS; DNA, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, BCL-2; GENES, P53; HUMANS; IN SITU NICK-END LABELING; MALE; MIDDLE AGED; POINT MUTATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS P21(RAS); TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0346101695     PISSN: 13419625     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10147-003-0352-6     Document Type: Article

References (16)

1. Mitsutomi T, Chiba I (1992) A study on p53, an antioncogene, and its significance in clinical oncology. Protein, Nucleic Acid and Enzyme 37:1491-1505
2. Gavrieli Y, Sherman Y, Ben-Sasson SA (1992) Identification of programmed cell death in situ via specific labeling of Nuclear DNA fragmentation. J Cell Biol 119:493-501
3. Sanger F, Nicklen S, Coulson AR (1997) DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74:5463-5467
4. Kerr JFR, Wyllie AH, Currie AR (1972) Apoptosis. A basic biological phenomenon with wide ranging implications in tissue kinetics. Br J Cancer 26:239-257
5. Lane DP (1992) Cancer: p53 guardian of the genome. Nature 358:15-16
6. Baker SJ, Preisinger AC, Jessup JM (1990) p53 gene mutations occurred in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res 50:7717-7722
7. Scott N, Sanger P, Stewart J, et al. (1991) p53 in colorectal cancer: clinicopathological correlation and prognostic significance. Br J Cancer 63:317-319
8. Purdie CA, O'Grady J, Piris J (1991) p53 expression in colorectal tumors. Am J Pathol 138:807-813
9. Yang Z, Perkins ND, Ohno T, et al. (1995) The p21 cyclin-dependent kinase inhibitor suppresses tumorigenicity in vivo. Nature Med 1:1052-1056
10. Tokino T (1995) Study on target gene of p53 - primarily on p21/waf1. Exp Med 13:1656-1659
11. Miyashita T (1995) Transcriptional control of bax by p53. Exp Med 13:1873-1875
12. Vaux DL, Cory S, Adams JM (1988) Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335:440-442
13. Wyllie AH (1980) Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284:555-556
14. Garvieli Y, Sherman Y, Ben-Sasson SA (1992) Identification of programmed cell death in site via specific labeling of nuclear DNA fragmentation. J Cell Biol 119:493-501
15. Katada M, Sugiyama Y, Kunieda K (1999) An immunohistological study on influences by proteins relating to apoptosis in malignant process in adenoma of the large intestine. J Jpn Assoc Digestive Tract Surg 32:2224-2230
16. Sheikh MS, Chen YQ, Smith ML, et al. (1997) Role of p21 Waf1/Cip1/Sdi1 in cell death and DNA repair as studied using a tetracycline-induced system in p53-deficient cells. Oncogene 14:1875-1882