Enzymatic and hyperglycemia stability of chemically modified insulins with hydrophobic acyl groups

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 2, 2004, Pages 481-483

  Nakashima, Kentaro ^a   Miyagi, Makoto ^a   Goto, Koichi ^a   Matsumoto, Yoko ^a   Ueoka, Ryuichi ^a  

^a SOJO UNIVERSITY   (Japan)

Author keywords

Acylated insulin; Diabetes; Digestive enzyme; Hypoglycemia

Indexed keywords

BENZOIC ACID DERIVATIVE; ESTER DERIVATIVE; HEXANOIC ACID DERIVATIVE; INSULIN; RECOMBINANT HUMAN INSULIN; SUCCINIMIDE DERIVATIVE;

ACYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DECOMPOSITION; DRUG SYNTHESIS; ENZYME STABILITY; HYDROPHOBICITY; HYPERGLYCEMIA; HYPOGLYCEMIA; MALE; NONHUMAN; RAT;

ANIMALIA;

EID: 0346099263     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.10.037     Document Type: Article

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16. -1) and centrifuged (2500 rpm) for 25 min at room temperature. The glucose concentration in blood plasma was measured by glucose oxidase method using Fuji DRI-CHEM 3500V (FUJIFILM MEDICAL).