A novel water-soluble and cell-permeable calpain inhibitor protects myocardial and mitochondrial function in postischemic reperfusion

Biological Chemistry

Volumn 384, Issue 12, 2003, Pages 1597-1603

  Neuhof, Christiane ^a   Götte, Oliver ^a   Trumbeckaite, Sonata ^b   Attenberger, Markus ^a   Kuzkaya, Nermin ^a   Gellerich, Frank ^c   Möller, Achim ^d   Lubisch, Wilfried ^d   Speth, Maria ^a   Tillmanns, Harald ^a   Neuhof, Heinz ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b KAUNAS UNIVERSITY OF MEDICINE   (Lithuania)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^d ABBOTT GMBH AND CO KG   (Germany)

Author keywords

Coronary flow; Dose response relationship; Enzyme release; Left ventricular pressure; Tissue concentration

Indexed keywords

A 705239; CALPASTATIN; CREATINE KINASE; LACTATE DEHYDROGENASE; OXYGEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DRUG ACCUMULATION; DRUG ACTIVITY; DRUG RESEARCH; DRUG TISSUE LEVEL; ENZYME RELEASE; FEMALE; HEART FUNCTION; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE ISCHEMIA; HEART MUSCLE PERFUSION; HEART PROTECTION; ISOLATED HEART; MALE; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; RABBIT; REPERFUSION INJURY; SOLUBILITY;

ADENOSINE DIPHOSPHATE; ANIMALS; ANTIMYCIN A; ATRACTYLOSIDE; BENZAMIDES; CALPAIN; CORONARY CIRCULATION; CREATINE KINASE; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEART; HEART RATE; L-LACTATE DEHYDROGENASE; MALE; MITOCHONDRIA, HEART; MYOCARDIAL CONTRACTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; OXYGEN CONSUMPTION; RABBITS; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0346097918     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2003.177     Document Type: Article

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