Alpha and Omega of Carotenoid Cleavage

Journal of Nutrition

Volumn 134, Issue 1, 2004, Pages

  Lakshman, M R ^a  

^a GEORGE WASHINGTON UNIVERSITY   (United States)

Author keywords

Central cleavage; Dioxygenase; Eccentric cleavage; Vitamin A; carotene

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; BETA CAROTENE; BETA,BETA CAROTENE 15,15' DIOXYGENASE; CAROTENOID; CELL ENZYME; ETHYLENE; FERROUS ION; OXYGENASE; RECOMBINANT PROTEIN; RETINAL; RETINOL; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

CHEMICAL BOND; CHICKEN; CLONE; CONFERENCE PAPER; DROSOPHILA MELANOGASTER; DUODENUM MUCOSA; ENZYME LOCALIZATION; ENZYME MECHANISM; MASS SPECTROMETRY; METABOLISM; NONHUMAN; OXIDATION; RABBIT; RAT; SWINE;

DROSOPHILA MELANOGASTER; GALLUS GALLUS; MELANOGASTER; ORYCTOLAGUS CUNICULUS; SUS SCROFA;

EID: 0346095552     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/134.1.241s     Document Type: Conference Paper

References (26)

1. Steenbock, H. (1919) White corn vs yellow corn and a probable relationship between the fat soluble viamins and yellow plant pigments. Science 50: 352.
2. Drummond, J. C., Ahmad, B. & Morton, R. A. (1930) Further observations on the relation of carotenes to vitamin A. J. Soc. Chem. Ind. 49: 291T.
3. Moore, T. (1930) Vitamin A and carotene VI. The conversion of carotene to vitamin A in vivo. Biochem. J. 24: 692.
4. Olson, J. A. & Hayaishi, O. (1965) The enzymatic cleavage of β-carotene into vitamin A by soluble enzymes of rat liver and intestine. Proc. Natl. Acad. Sci. U.S.A. 54: 1364-1369.
5. Goodman, D. S. & Huang, H. S. (1965) Biosynthesis of vitamin A with rat intestinal enzymes. Science 149: 879-880.
6. Goodman, D. S., and Huang, H. S. & Shiratori, T. (1966) Mechanism of biosynthesis of vitamin A from β-carotene. J. Biol. Chem. 242: 1929-1932.
7. Goodman, D. S., Huang, H. S., Kanai, M. & Shiratori, T. (1967) The enzymatic conversion of all-trans β-carotene into retinal. J. Biol. Chem. 242: 3543-3554.
8. Lakshman, M. R., Pope, J. L. & Olson, J. A. (1968) The specificity of a partially purified carotenoid cleavage enzyme of rabbit intestine. Biochem. Biophys. Res. Commun. 33: 347-352.
9. Lakshman, M. R., Chansang, H. & Olson, J. A. (1972) Purification and properties of carotenoid 15,15′-dioxygenase of rabbit intestine. J. Lipid. Res. 13: 477-482.
10. Gawienowski, A. M., Stacewicz, M. & Longley, R. (1974) Biosynthesis of retinal in bovine corpus luteum. J. Lipid. Res. 15: 375-379.
11. Singh, H. & Cama, H. R. (1974) Enzymatic cleavage of carotenoids. Biochim. Biophys. Acta. 370: 49-61.
12. Glover, J. & Redfearn, E. R. (1954) The mechanism of transformation of β-carotene into vitamin A in vivo. Biochem. J. 58: 15-16.
13. Sharma, R. V., Mathur, S. N., Dmitrovskii, A. A., Das, R. C. & Ganguly, J. (1977) Studies on the metabolism of β-carotene and apo-β-carotenoids in rats. Biochim. Biophys. Acta. 485: 183-194.
14. Hansen, S. & Maret, W. (1988) Retinal is not formed in vitro. Biochemistry 27: 200-206.
15. Wang, X. D., Tang, G. W., Fox, J. G., Krinsky, N. I. & Russell. R. M. (1991) Enzymatic conversion of β-carotene into β-apocarotenals and retinoids by human, monkey, ferret and rat tissues. Arch. Biochem. Biophys. 285: 8-16.
16. Tang, G., Wang, X.-D., Russell, R. M. & Krinsky, N. I. (1991) Characterization of β-apo-13-carotenone and β-apo-14′-carotenal as enzymatic products of the excentric cleavage of β-carotene. Biochemistry 30: 9829-9834.
17. Lakshman, M. R., Mychovsky, I. & Attlesey, M. (1989) Enzymatic conversion of all-trans-β-carotene to retinal by a cytosolic enzyme from rabbit and rat intestinal mucosa. Proc. Natl. Acad. Sci. U.S.A. 86: 9124-9128.
18. Napoli, J. L. & Race, K. R. (1988) Biogenesis of retinoic acid from β-carotene. J. Biol. Chem. 263: 17372-17377.
19. Ahmad, B. (1931) The fate of carotene after absorption in animal organism. Biochem. J. 25: 1195-1204.
20. Devery, J. & Milborrow, B. V. (1994) β-carotene-15,15′ -dioxygenase (1.13.11.21) isolation reaction mechanism and improved assay procedure. Brit. J. Nutr. 72: 397-414.
21. Nagao, A., During, A., Hoshino, C., Terao, J. & Olson, J. A. (1996) Stoichiometric conversion of all-trans-β-carotene to retinal by pig intestinal extract. Arc. Biochem. Biophys. 328: 57-63.
22. Yeum, K. J., Ferreira, A. L., Smith. D., Krinsky, N. I. & Russell, R. M. (2000) The effect of α-tocopherol on the oxidative cleavage of β-carotene. Free Radic. Biol. Med. 29: 105-114.
23. Barua, A. B. & Olson, J. A. (2000) β-carotene is converted primarily to retinoids in vivo. J. Nutr. 130: 1996-2001.
24. von Lintig, J. & Vogt, K. (2000) Filling the gap in vitamin A research. J. Biol. Chem. 275: 11915-11920.
25. Wyss, A., Wirtz, G., Woggon, W. D., Brugger, R., Wyss, M., Friedlein, A., Bachmann, H. & Hunziker, W. (2000) Cloning and expression of β-carotene-15, 15′-dioxygenase. Biochim. Biophys. Res. Commun. 271: 334-336.
26. Yan, W., Jang. G. F., Haeseleer, F., Esumi, N., Chang, J., Kerrigan, M., Campochiaro, M., Campochiaro, P., Palczewski, K. & Zack, D. J. (2001) Cloning and characterization of a human β, β-carotene-15,15′ -dioxygenase that is highly expressed in the retinal pigment epithelium. Genomics 72: 193-202.