Adenovirus-mediated tumor-specific combined gene therapy using Herpes simplex virus thymidine/ganciclovir system and murine interleukin-12 induces effective antitumor activity against medullary thyroid carcinoma

Cancer Gene Therapy

Volumn 11, Issue 1, 2004, Pages 8-15

  Yamazaki, Masanori ^a   Straus, Francis H ^a   Messina, Marinella ^b   Robinson, Bruce G ^b,c   Takeda, Teiji ^d   Hashizume, Kiyoshi ^d   DeGroot, Leslie J ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b ROYAL NORTH SHORE HOSPITAL   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Calcitonin; Herpes simplex type 1 thymidine kinase ganciclovir; Interleukin 12; Medullary thyroid carcinoma; Tissue specific promoter

Indexed keywords

ADENOVIRUS VECTOR; CALCITONIN; GANCICLOVIR; INTERLEUKIN 12; LIVER ENZYME; THYMIDINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG SPECIFICITY; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; IN VITRO STUDY; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RAT; THYROID MEDULLARY CARCINOMA; TISSUE SPECIFICITY; TREATMENT INDICATION; TREATMENT OUTCOME; VIRAL GENE THERAPY; VIRUS INFECTION; VIRUS RECOMBINANT; WEIGHT REDUCTION;

ADENOVIRIDAE; ANIMALS; CARCINOMA, MEDULLARY; CELL DIVISION; CELL LINE, TUMOR; GANCICLOVIR; GENE THERAPY; HUMANS; INTERLEUKIN-12; MICE; NEOPLASM TRANSPLANTATION; ORGAN SPECIFICITY; RATS; SIMPLEXVIRUS; THYMIDINE KINASE; THYROID NEOPLASMS;

ADENOVIRIDAE; ANIMALIA; HUMAN HERPESVIRUS 1; MURINAE; SIMPLEXVIRUS;

EID: 0346095388     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700636     Document Type: Article

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