Are Individual Patient Trials (n-of-1 Trials) in Rheumatology Worth the Extra Effort?

Journal of Rheumatology

Volumn 31, Issue 1, 2004, Pages 8-11

  Peloso, Paul M ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA HEALTH CARE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; ARTHROTEC; DICLOFENAC; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PLACEBO;

ANALGESIA; CLINICAL TRIAL; CROSSOVER PROCEDURE; DRUG EFFICACY; DRUG SAFETY; EDITORIAL; FIBROMYALGIA; HUMAN; OSTEOARTHRITIS; OUTCOMES RESEARCH; PATIENT SATISFACTION; PRIORITY JOURNAL; QUESTIONNAIRE; RANDOMIZATION; RHEUMATOID ARTHRITIS;

ANTIRHEUMATIC AGENTS; HUMANS; RANDOMIZED CONTROLLED TRIALS; RHEUMATIC DISEASES; RHEUMATOLOGY;

EID: 0346057902     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Editorial

References (17)

1. Guyatt GH, Sackett DL, Adachi JD, et al. A clinicians' guide for conducting randomized trials in individual patients, CMAJ 1988;139:497-503.
2. Guyatt GH, Keller JL, Jaeschke R, Rosenbloom D, Adachi JD, Newhouse MT. The n-of-1 randomized controlled trial: clinical usefulness. Our three-year experience. Ann Intern Med 1990;112:293-9.
3. Randomization designs for single-case and small-n studies. In: Todman JB, Dugard P, editors. Single-case and small-n experimental designs. A practical guide to randomization. Mahwah, NJ: Lawrence Erlbaum Associates; 2001.
4. Felson D, Anderson JJ, Boers M. et al. American College of Rheumatology. Preliminary definition of improvement in rheumatoid arthritis. Arthritis Rheum 1995;38:727-35.
5. Zucker DR, Schmid CH, McIntosh MW, D'Agosfino RB, Selker HP, Lau J. Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment. J Clin Epidemiol 1997;50:401-10.
6. Larson EB, Ellsworth AJ, Oas J. Randomized clinical trials in single patients during a 2-year period. JAMA 1993;270:2708-12.
7. Knowles SR, Uetrecht JP, Shear NH. Confirming false adverse reactions to drugs by performing individualized, randomized trials. Can J Clin Pharmacol 2002;9:149-53.
8. Statistical and visual analysis. In: Todman JB, Dugard P, editors. Single-case and small-n experimental designs. A practical guide to randomization. Mahwah, NJ: Lawrence Erlbaum Associates; 2001.
9. Jaeschke R, Adachi J, Guyatt G, Keller J, Wong B. Clinical usefulness of amitriptyline in fibromyalgia: the results of 23 N-of-1 randomized controlled trials. J Rheumatol 1991;18:447-51.
10. March L, Irwig L, Schwarz J, Simpson J, Chock C, Brooks P. N of 1 trials comparing a non-steroidal anti-inflammatory drug with paracetamol in osteoarthritis. BMJ 1994;309:1041-5;1045-6 [discussion]; 1995;310:66-7 [comment].
11. March L, Irwig L, Schwarz J, Simpson J, Chock C, Brooks P. N of 1 trials comparing a non-steroidal anti-inflammatory drug with paracetamol in osteoarthritis. BMJ 1994;309:1041-5;1045-6 [discussion]; 1995;310:66-7 [comment].
12. Carette S, McCain GA, Bell DA, Fam AG. Evaluation of amitriptyline in primary fibrositis. Arthritis Rheum 1986;29:655-9.
13. Carette S, Bell MJ, Reynolds WB, et al. Comparison of amitriptyline, cyclobenzaprine, and placebo in the treatment of fibromyalgia. A randomized, double-blind clinical trial. Arthritis Rheum 1994;37:32-40.
14. Case JP, Baliunas AJ, Block JA. Lack of efficacy of acetaminophen in treating symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled comparison trial with diclofenac sodium. Arch Intern Med 2003;163:169-78.
15. Pincus T, Koch GG, Sokka T, et al. A randomized, double-blind, crossover clinical trial of diclofenac plus misoprostol versus acetaminophen in patients with osteoarthritis of the hip or knee. Arthritis Rheum 2001;44:1587-98.
16. Pope JE, Prashker M, Anderson J. The efficacy and cost-effecfiveness of n of 1 studies with diclofenac compared to standard treatment with nonsteroidal antiinflammatory drugs in osteoarthritis. J Rheumatol 2004;31:140-9.
17. Bruce B, Fries JF. The Stanford Health Assessment Questionnaire: dimensions and practical applications. Health Qual Life Outcomes 2003;9;1:20. Internet [accessed November 2, 2003]. Available from: http://www.pubmedcentral.nih.gov/articierender.fcgi? rendertype=abstract& artid=165587