Solid-phase chemical synthesis of phosphonoacetate and thiophosphonoacetate oligodeoxynucleotides

Journal of the American Chemical Society

Volumn 125, Issue 4, 2003, Pages 940-950

  Dellinger, Douglas J ^b,c   Sheehan, David M ^a,d   Christensen, Nanna K ^a,e   Lindberg, James G ^b   Caruthers, Marvin H ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b MetaSense Technologies   (United States)

^c AGILENT LABORATORIES   (United States)

^d SEQUENOM INC   (United States)

^e UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ION EXCHANGE; MONOMERS; RNA; SYNTHESIS (CHEMICAL);

OLIGODEOXYNUCLEOTIDES; PHOSPHONOACETATE; THIOPHOSPHONOACETATE;

ACETIC ACID;

(10 CAMPHORSULFONYL)OXAZIRIDINE; 3' O PHOSPHINOAMIDITE; 3H 1,2 BENZODITHIOL 3 ONE 1,1 DIOXIDE; 5' O (4,4' DIMETHOXYTRITYL) 2' DEOXYNUCLEOSIDE; GLASS; MONOMER; NUCLEOSIDE DERIVATIVE; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; OXAZIRIDINE DERIVATIVE; PHOSPHODIESTERASE; PHOSPHONOACETIC ACID; RIBONUCLEASE H; SNAKE VENOM; TETRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; DNA SYNTHESIS; HYDROLYSIS; ION EXCHANGE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; OXIDATION; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; REFORMATSKY REACTION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLID;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OLIGONUCLEOTIDES; PHOSPHONOACETIC ACID; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; THIOPHOSPHORIC ACID ESTERS;

EID: 0346003765     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja027983f     Document Type: Article

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