The significance of gemistocytes in astrocytoma

Acta Neurochirurgica

Volumn 145, Issue 12, 2003, Pages 1097-1103

  Yang, H J ^a   Kim, J E ^a   Paek, S H ^a   Chi, J G ^a   Jung, H W ^a   Kim, D G ^a,b   Paulus, W ^c  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University Hospital   (South Korea)

^c NONE

Author keywords

Apoptosis; Astrocytoma; Gemistocyte; Prognosis; Proliferative potential

Indexed keywords

CYCLINE; KI 67 ANTIGEN; PROTEIN BCL 2; PROTEIN P53;

ADULT; AGED; ANAPLASTIC CARCINOMA; ARTICLE; ASTROCYTE; ASTROCYTOMA; CANCER DIAGNOSIS; CANCER SURVIVAL; CELL; CONTROLLED STUDY; EVALUATION; FEMALE; FOLLOW UP; GEMISTOCYTE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MALIGNANT TRANSFORMATION; NICK END LABELING; PRIORITY JOURNAL; PROGNOSIS; RECURRENT DISEASE; RETROSPECTIVE STUDY; SURVIVAL RATE; SURVIVAL TIME; TUMOR;

ADULT; AGED; ASTROCYTES; ASTROCYTOMA; BRAIN; BRAIN NEOPLASMS; CELL COUNT; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IN SITU NICK-END LABELING; KI-67 ANTIGEN; MALE; MIDDLE AGED; PROGNOSIS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTO-ONCOGENE PROTEINS C-BCL-2; RETROSPECTIVE STUDIES; SURVIVAL RATE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0345865246     PISSN: 00016268     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00701-003-0149-4     Document Type: Article

References (28)

1. Allan DJ, Howell A, Roberts SA, Williams GT, Watson RJ, Coyne JD, Clarke RB, Laidlaw IJ, Potten CS (1992) Reduction in apoptosis relative to mitosis in histologically normal epithelium accompanies fibrocystic change and carcinoma of the premenopausal human breast. J Pathol 167: 25-32
2. Chozick BS, Pezzullo JC, Epstein MH, Finch PW (1994) Prognostic implications of p53 overexpression in supratentorial astrocytic tumors. Neurosurgery 35: 831-837
3. Cory S, Strasser A, Jacks T, Corcoran LM, Metz T, Harris AW, Adams JM (1994) Enhanced cell survival and tumorigenesis. Cold Spring Harb Symp Quant Biol 59: 365-375
4. Daumas-Duport C, Scheithauer B, O'Fallon J, Kelly P (1988) Grading of astrocytomas. A simple and reproducible method. Cancer 62: 2152-2165
5. Dean BL, Drayer BP, Bird CR, Florn RA, Hodak JA, Coons SW, Carey RG (1990) Gliomas: classification with MR imaging. Radiology 174: 411-415
6. Gavrieli Y, Sherman Y, Ben-Sasson SA (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119: 493-501
7. Heesters MA, Koudstaal J, Go KG, Molenaar WM (1999) Analysis of proliferation and apoptosis in brain gliomas: prognostic and clinical value. J Neurooncol 44: 255-266
8. Hoshino T, Wilson BC, Ellis WG (1975) Gemistocytic astrocytes in gliomas. An autoradiographic study. J Neuropathol Exp Neurol 34: 263-281
9. Karamitopoulou E, Perentes E, Diamantis I (1993) p53 protein expression in central nervous system tumors: an immunomstochemical study with CM1 polyvalent and DO-7 monoclonal antibodies. Acta Neuropathol 85: 611-616
10. Karamitopoulou E, Perentes E, Diamantis I, Maraziotis T (1994) Ki-67 immunoreactivity in human central nervous system tumors: a study with MIB 1 monoclonal antibody on archival material. Acta Neuropathol 87: 47-54
11. Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26: 239-257
12. Kleihues P, Davis RL, Coons SW, Burger PC (2000) Anaplastic astrocytoma. In: Kleihues P, Cavenee WK (eds) Pathology and genetics of tumours of the nervous system. IARC press, Lyon, pp 27-28
13. Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC, Cavenee WK (2002) The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 61: 215-225; discussion 226-229
14. Krouwer HGJ, Davis RL, Silver P, Prados M (1991) Gemistocytic astrocytomas: a reappraisal. J Neurosurg 74: 399-406
15. Louis DN (1994) The p53 gene and protein in human brain tumors. J Neuropathol Exp Neurol 53: 11-21
16. McKeever PE, Ross DA, Strawderman MS, Brunberg JA, Greenberg HS, Junck L (1997) A comparison of the predictive power for survival in gliomas provided by MIB-1, bromodeoxyuridine and proliferating cell nuclear antigen with histopathologic and clinical parameters. J Neuropathol Exp Neurol 56: 798-805
17. McKeever PE, Strawderman MS, Yamini B, Mikhail AA, Blaivas M (1998) MIB-1 proliferation index predicts survival among patients with grade II astrocytoma. J Neuropathol Exp Neurol 57: 931-936
18. Onda K, Davis RL, Wilson CB, Hoshino T (1994) Regional differences in bromodeoxyuridine uptake, expression of Ki-67 protein, and nucleolar organizer region counts in glioblastoma multiforme. Acta Neuropathol 87: 586-593
19. Paulus W, Grothe C, Sensenbrenner M, Janet T, Baur I, Graf M, Roggendorf W (1990) Localization of basic fibroblast growth factor, a mitogen and angiogenic factor, in human brain tumors. Acta Neuropathol 79: 418-423
20. Reis RM, Hara A, Kleihues P, Ohgaki H (2001) Genetic evidence of the neoplastic nature of gemistocytes in astrocytomas. Acta Neuropathol (Berl) 102: 422-425
21. Russell DS, Rubinstein LJ (1989) Pathology of tumors of the central nervous system. Williams & Wilkins, Baltimore
22. Schiffer D, Cavalla P, Migheli A, Chio A, Giordana MT, Marino S, Attanasio A (1995) Apoptosis and cell proliferation in human neuroepithelial tumors. Neurosci Lett 195: 81-84
23. Schiffer D, Chio A, Giordana MT, Leone M, Soffietti R (1988) Prognostic value of histologic factors in adult cerebral astrocytoma. Cancer 61: 1386-1393
24. Shinoda J, Sakai N, Nakatani K, Funakoshi T (1998) Prognostic factors in supratentorial WHO grade II astrocytoma in adults. Br J Neurosurg 12: 318-324
25. Tatter SB, Wilson CB, Harsh GR IV (1996) Neuroepithelial tumors of the adult brain. In: Youmans JR (ed) Neurological surgery. W. B. Saunders, Philadelphia, pp 2612-2684
26. Vital A, Loiseau H, Kantor G, Daucourt V, Chene G, Cohadon F, Rougier A, Rivel J, Vital C (1998) p53 protein expression in grade II astrocytomas: immunohistochemical study of 100 cases with long-term follow-up. Pathol Res Pract 194: 831-836
27. Watanabe K, Peraud A, Gratas C, Wakai S, Kleihues P, Ohgaki H (1998) p53 and PTEN gene mutations in gemistocytic astrocytomas. Acta Neuropathol (Berl) 95: 559-564
28. Watanabe K, Tachibana O, Yonekawa Y, Kleihues P, Ohgaki H (1997) Role of gemistocytes in astrocytoma progression. Lab Invest 76: 277-284