A new method for rapidly and simultaneously decreasing serotonin and catecholamine synthesis in humans

Journal of Psychiatry and Neuroscience

Volumn 28, Issue 6, 2003, Pages 464-467

  Leyton, Marco ^a   Pun, Valerie Kwai ^a   Benkelfat, Chawki ^a   Young, Simon N ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Catecholamines; Dopamine; Norepinephrine; Phenylalanine; Serotonin; Tryptophan; Tyrosine

Indexed keywords

AMINO ACID MIXTURE; CATECHOLAMINE; PHENYLALANINE; SEROTONIN; TRYPTOPHAN; TRYPTOPHYLPHENYLALANYLTYROSINE DEFICIENT AMINO ACID MIXTURE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BOREDOM; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; FEMALE; HAPPINESS; HUMAN; INGESTION; IRRITABILITY; MALE; MEASUREMENT; MOOD DISORDER; NORMAL HUMAN; PROTEIN BLOOD LEVEL; PROTEIN DEPLETION; PROTEIN SYNTHESIS; VISUAL ANALOG SCALE; VOLUNTEER;

ADULT; AMINO ACIDS; BRAIN; CATECHOLAMINES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DRUG COMBINATIONS; FEMALE; FLUOROMETRY; HUMANS; MALE; MOOD DISORDERS; PHENYLALANINE; PILOT PROJECTS; SEROTONIN; TIME FACTORS; TRYPTOPHAN; TYROSINE;

EID: 0345865043     PISSN: 11804882     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Sulser F. Serotonin-norepinephrine receptor interactions in the brain: implications for the pharmacology and pathophysiology of affective disorders. J Clin Psychiatry 1987;48(3 Suppl):12-8.
2. Geracioti TD Jr, Loosen PT, Ekhator NN, Schmidt D, Chambliss B, Baker DG, et al. Uncoupling of serotonergic and noradrenergic systems in depression: preliminary evidence from continuous cerebrospinal fluid sampling. Depress Anxiety 1997;6:89-94.
3. Kish SJ, Kalasinsky KS, Derkach P, Schmunk GA, Guttman M, Ang L, et al. Striatal dopaminergic and serotonergic markers in human heroin users. Neuropsychopharmacology 2001;24:561-7.
4. Goodwin FK, Bunney WE Jr. Depressions following reserpine: a reevaluation. Semin Psychiatry 1971;3:435-48.
5. Salomon RM, Miller HL, Krystal JH, Heninger GR, Charney DS. Lack of behavioral effects of monoamine depletion in healthy subjects. Biol Psychiatry 1997;41:58-64.
6. McCann UD, Penetar DM, Belenky G. Acute dystonic reaction in normal humans caused by catecholamine depletion. Clin Neuropharmacol 1990;13:565-8.
7. Brogden RN, Heel RC, Speight TM, Avery GS. α-Methyl-p-tyrosine: a review of its pharmacology and clinical use. Drugs 1981;21:81-9.
8. Moja EA, Restani P, Corsini E, Stacchezzini MC, Assereo R, Galli CL. Cycloheximide blocks the fall of plasma and tissue tryptophan levels after tryptophan-free amino acid mixtures. Life Sci 1991;49:1121-8.
9. Moja EA, Rocchi E, Benedetti F, Paolillo F, Casalgrandi G, Ponz de Leon M. Decrease in plasma tryptophan after a tryptophan-free amino acid solution. A comparison between cirrhotic and control subjects. Life Sci 1991;48:409-18.
10. First MB, Spitzer RI, Gibbon M. Axis I disorders. New York: New York State Psychiatric Institute; 1995.
11. Andreasen NC, Endicott J, Spitzer RL, Winokur G. The family history method using diagnostic criteria: reliability and validity. Arch Gen Psychiatry 1977;34:1229-35.
12. Beck AT, Ward CH, Mendelson M, Mock JE, Erbaugh JK. An inventory for measuring depression. Arch Gen Psychiatry 1961; 4:561-71.
13. Young SN, Smith SE, Pihl RO, Ervin FR. Tryptophan depletion causes a rapid lowering of mood in normal males. Psychopharmacology 1985;87:173-7.
14. Ellenbogen MA, Young SN, Dean P, Palmour RM, Benkelfat C. Mood responses to acute tryptophan depletion in healthy volunteers: sex differences and temporal stability. Neuropsychopharmacology 1996;15:465-74.
15. Leyton M, Young SN, Pihl RO, Etezadi S, Lauze C, Blier P, et al. Effects on mood of acute phenylalanine/tyrosine depletion in healthy women. Neuropsychopharmacology 2000;22:52-63.
16. Lorr M, McNair DM, Fisher S. Evidence for bipolar mood states. J Pers Assess 1982;46:432-6.
17. McNair DM, Lorr M, Droppleman LF. Manual for the profile of mood states. San Diego (CA): Educational and Industrial Testing Service; 1988.
18. Bond A, Lader M. The use of analog scales in rating subjective feelings. Br J Med Psychol 1974;47:211-8.
19. Palmour RM, Ervin FR, Baker GB, Young SN. Effects of acute tryptophan depletion and acute tyrosine/phenylalanine depletion on CSF amine metabolite levels and voluntary alcohol consumption in vervet monkeys. Psychopharmacology 1998;136:1-7.
20. McTavish SF, Cowen PJ, Sharp T. Effect of a tyrosine-free amino acid mixture on regional brain catecholamine synthesis and release. Psychopharmacology 1999;141:182-8.
21. 11C]raclopride study in healthy men. Neuropsychopharmacology. In press.
22. Young SN, Leyton M. The role of serotonin in human mood and social interaction: insight from altered tryptophan levels. Pharmacol Biochem Behav 2002;71:857-65.