The amygdaloid body: Functional implications;La amígdala: Implicaciones funcionales

Revista de Neurologia

Volumn 33, Issue 5, 2001, Pages 471-476

  Torras, M ^a   Portell, I ^a   Morgado Bernal, Ignacio ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Amygdaloid body; Conditioned fear; Emotion; Learning; Memory; Modulation of the memory

Indexed keywords

EID: 0345857979     PISSN: 02100010     EISSN: None     Source Type: Journal    
DOI: 10.33588/rn.3305.2001125     Document Type: Article

References (105)

1. Alheid GF, de Olmos JS, Beltramino CA. Amygdala and extended amygdala. In Paxinos G, ed. The Rat Nervous System. 2 ed. Sydney: Academic Press; 1995. p. 183-213.
2. Amaral DG, Price JL, Pitkänen A, Carmichael ST. Anatomical organization of the primate amygdaloid complex. In Aggleton JP, ed. The Amygdala: Neurobiological Aspects of Emotion, Memory, and Mental Dysfunction. New York: Wiley-Liss; 1992. p. 1-66.
3. Pitkänen A, Savander V, LeDoux JE. Organization of intra-amygdaloid circuitries in the rat: an emerging framework for understanding functions of the amygdala. Trends Neurosci 1997; 20: 517-23.
4. LeDoux, JE. Emotion and the amygdala. In Aggleton, ed. The amygdala: neurobiological aspects of emotion, memory, and mental dysfunction. New York: Wiley-Liss; 1992. p. 339-51.
5. Davis, M. The role of the amygdala in conditioned fear. In Aggleton JP, ed. The amygdala: neurobiological aspects of emotion, memory, and mental dysfunction. New York; Wiley-Liss; 1992. p. 255-305.
6. McGaugh JL, Introini-Collison IB, Cahill L, Kim M, Liang KC. Involvement of the amygdala in neuromodulatory influences on memory storage. In Aggleton JP, ed. The amygdala: neurobiological aspects of emotion, memory, and mental dysfunction. New York: Wiley-Liss 1992; p. 1-66.
7. Klüver H, Bucy PC. 'Psychic blindness' and other symptoms following bilateral temporal lobectomy in rhesus monkeys. Am J Physiol 1937; 119: 352-3.
8. Schreiner L, Kling A Behavioral changes following rhinencephalic injury in cat. J Neurophysiol 1953; 16: 643-59.
9. Aggleton, JP. The functional effects of amygdala lesions in humans: A comparison with findings from monkeys. In Aggleton JP, ed. The amygdala: neurobiological aspects of emotion, memory, and mental dysfunction. New York: Wiley-Liss 1992; p. 485-503.
10. Broks P, Young AW, Maratos EJ, Coffey PJ, Calder AJ, Isaac CL, et al. Face processing impairments after encephalitis: amygdala damage and recognition of fear. Neuropsychologia 1998; 36: 59-70.
11. Hamann SB, Stefanacci L, Squire LR, Adolphs R, Tranel D, Damasio H, et al. Recognizing facial emotion. Nature 1996; 379: 497
12. Hayman LA, Rexer JL, Pavol MA, Strite D, Meyers CA. Küver-Bucy syndrome after bilateral selective damage of amygdala and its cortical connections. J Neuropsychiatry 1998; 10: 354-8.
13. Young AW, Aggleton JP, Hellawell DJ, Johnson M, Broks P, Hanley RH. Face processing impairments after amygdalotomy. Brain 1995; 118: 15-24.
14. Adolphs R, Tranel D, Damasio H, Damasio A. Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala. Nature 1994; 372: 669-72.
15. Adolphs R, Tranel D, Damasio H, Damasio A. Fear and the human amygdala. J Neurosci 1995; 15: 5879-91.
16. Scott SK., Young AW, Calder AJ, Hellawell DJ, Aggleton JP, Johnson MJ. Impaired auditory recognition of fear and anger following bilateral amygdala lesions. Nature 1997; 385: 254-7.
17. Anderson AK, Phelps EA. Intact recognition of vocal expressions of fear fol-lowing bilateral lesions of the human amygdala. Neuroreport 1998; 9: 3607-13.
18. Morris JS, Frith CD, Perrett DI, Rowland D, Young AW, Calder AJ, Dolan RJ. A differential neural response in the human amygdala to fearful and happy facial expressions. Nature 1996; 383: 812-5.
19. Morris JS, Friston KJ, Büchel C, Frith CD, Young AW, Calder AJ, et al. A neuromodulatory role for the human amygdala in processing emotional facial expressions. Brain 1998; 121: 47-54.
20. Phillips ML, Young AW, Scott SK, Calder AJ, Andrew C, Giampietro V, et al. Neural response to facial and vocal expressions of fear and disgust. Proc R Soc Lond Biol Sci 1998; 265: 1809-17.
21. Lane RD, Reiman EM, Bradley MM, Lang PJ, Ahem GL, Davidson RJ, et al. Neuroanatomical correlates of pleasant and unpleasant emotion. Neuropsychologia 1997; 35: 437-44.
22. Phillips ML, Young AW, Senior C, Brammer M, Andrew C, Calder AJ, et al. A specific neural substrate for perceiving facial expressions of dis-gust. Nature 1997; 389: 495-8.
23. Schneider F, Grodd W, Weiss U, Klose U, Mayer KR, Nägele T, et al. Functional MRI reveals left amygdala activation during emotion. Psychiatry Res 1997; 76: 75-82.
24. Whalen PJ, Rauch SL, Etcoff NL, McInerney SC, Lee MB, Jenike MA. Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge. J Neurosci 1998; 18: 411-8.
25. Campeau S, Davis M. Involvement of the central nucleus and basolateral complex of the amygdala in fear conditioning measured with fear-potentiated startle in rats trained concurrently with auditory and visual conditioned stimuli. J Neurosci 1995; 15: 2301-11.
26. Cousens G, Otto T. Both pre- and posttraining excitotoxic lesions of the basolateral amygdala abolish the expression of olfactory and contextual fear conditioning. Behav Neurosci 1998; 112: 1092-103.
27. Maren S. Overtraining does not mitigate contextual fear conditioning deficits produced by neurotoxic lesions of the basolateral amygdala. J Neurosci 1998; 18: 3088-97.
28. Maren S, Aharonov G, Fanselow MS. Retrograde abolition of conditional fear after excitotoxic lesions in the basolateral amygdala of rats: Absence of a temporal gradient. Behav Neurosci 1996; 110: 718-26.
29. McNish KA, Gewirtz JC, Davis M. Evidence of contextual fear after lesions of the hippocampus: a disruption of freezing but not fear-potentiated startle. J Neurosci 1997; 17: 9353-60.
30. Davis M, Falls WA, Campeau S, Kim M. Fear-potentiated startle: A neural and pharmacological analysis. Behav Brain Res 1993; 58: 175-98.
31. Maren S. Synaptic transmission and plasticity in the amygdala. Mol Neurobiol 1996; 13: 1-22.
32. Quirk GJ, Armony JL, LeDoux JE. Fear conditioning enhances different temporal components of tone-evoked spike trains in auditory cortex and lateral amygdala. Neuron 1997; 19: 613-24.
33. Romanski LM, LeDoux JE. Equipotentiality of the thalamo-amygdala and thalamo-corticoamygdala circuits in auditory fear conditioning. J Neurosci 1992; 12: 4501-9.
34. Campeau S, Davis M. Involvement of subcortical afferents to the lateral nucleus of the amygdala in fear conditioning measured with fear-potentiated startle in rats trained concurrently with auditory and visual conditioned stimuli. J Neurosci 1995; 15: 2312-27.
35. Hitchcock JM, Davis M. Lesions of the amygdala, but not the cerebellum or red nucleus, block conditioned fear as measured with potentiated startle paradigm. Behav Neurosci 1986; 100: 11-22.
36. Kapp BS, Frysinger RC, Gallagher M, Haselton JR. Amygdala central nucleus lesions: effects on heart rate conditioning in the rabbit. Physiol Behav 1979; 23: 1109-17.
37. Kim M, Davis M. Electrolytic lesions of the amygdala block acquisition and expression of fear-potentiated startle even with extensive training but do not prevent reacquisition. Behav Neurosci 1993; 107: 580-95.
38. Campeau S, Miserindo MJ, Davis M. Intra-amygdala infusion of the N-methyl-D-aspartate receptor antagonist AP5 blocks acquisition but not expression of fear-potentiated startle to an auditory conditioned stimulus. Behav Neurosci 1992; 106: 469-574.
39. Clugnet MC, LeDoux JE. Synaptic plasticity in fear conditioning circuits: induction of LTP in the lateral nucleus of the amygdala by stimulation of the medial geniculate body. J Neurosci 1990; 10: 2818-24.
40. Fanselow MS, Kim J. Acquisition of contextual Pavlovian fear conditioning is blocked by application of an NMDA receptor antagonist D,L-2-amino-5-phosphonovaleric acid to the basolateral amygdala. Behav Neurosci 1994; 108: 210-2.
41. Huang YY, Kandel ER. Postsynaptic induction and PKA-dependent expression of LTP in the lateral amygdala. Neuron 1998; 21: 168-9.
42. Lee H, Kim JJ. Amygdalar NMDA receptors are critical for new fear learning in previously fear-conditioned rats. J Neurosci 1998; 18: 8444-54.
43. McKernan MG, Shinnick-Gallagher P. Fear conditioning induces a lasting potentiation of Synaptic currents in vitro. Nature 1997; 390: 607-11.
44. Miserindo MJD, Sananes CB, Melia KR, Davis M. Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala. Nature 1990; 345: 716-8.
45. Quirk GJ, Repa C, LeDoux JE. Fear conditioning enhances short-latency auditory responses of lateral amygdala neurons: parallel recordings in the freely behaving rat. Neuron 1995; 15: 1029-39.
46. Rogan MT, LeDoux JE. LTP is accompanied by commensurate enhancement of auditory-evoked responses in fear conditioning circuit. Neuron 1995; 15: 127-36.
47. Rogan MT, Staubli UV, LeDoux JE. Fear conditioning induces associative long-term potentiation in the amygdala. Nature 1997; 390: 604-7.
48. Maren S. Long-term potentiation in the amygdala: a mechanism for emotional learning and memory. J Neurosci 1999; 22: 561-7
49. LaBar KS, LeDoux JE, Spencer DD, Phelps CA. Impaired fear conditioning following unilateral temporal lobectomy in humans. J Neurosci 1995; 15: 6846-55.
50. Bechara A, Tranel D, Damasio H, Adolphs R, Rockland C, Damasio AR. Double dissociation of conditioning and declarative knowledge relative to the amygdala and hippocampus in humans. Science 1995; 269: 1115-8.
51. Furmark T, Fischer H, Wik G, Larsson M, Fredrikson M. The amygdala and individual differences in human fear amygdala. Neuroreport 1997; 8: 3957-60.
52. LaBar KS, Gatenby JC, Gore JC, LeDoux JE, Phelps EA. Human amygdala activation during conditioned fear acquisition and extinction: a mixed-trial fMRI study. Neuron 1998; 20: 937-45.
53. Morris JS, Öhman A, Dolan RJ. Conscious and unconscious emotional learning in the human amygdala. Nature 1998; 393: 467-74.
54. Cahill L, McGaugh JL. Mechanisms of emotional arousal and lasting declarative memory. Trends Neurosci 1998; 21: 294-9.
55. McGaugh JL, Vadarjanova A. Basolateral amygdala is not critical for cognitive memory of contextual fear conditioning. Proc Natl Acad Sci USA 1998; 95; 15003-7.
56. Vazdarjanova A, McGaugh JL. Basolateral amygdala is involved in modulating consolidation of memory for classical fear conditioning. J Neurosci 1999; 19: 6615-22.
57. Adolphs R, Cahill L, Schul R, Babinsky R. Impaired declarative memory for emotional material following bilateral amygdala damage in humans. Learn Mem 1997; 4: 291-30.
58. Cahill L, Babinsky R, Markowitsch HJ, McGaugh JL. The amygdala and emotional memory. Nature 1995; 377: 295-6.
59. Cahill L, Haier RJ, Fallons J, Alkire MT, Tang C, Keator D, et al. Amygdala activity at encoding correlated with long-term, free recall of emotional information. Proc Natl Acad Sci USA 1996; 93: 8016-21.
60. Alkire MT, Haier RJ, Falton JH, Cahill L. Hippocampal, but not amygdala, activity at encoding correlates with long-term, free recall of nonemotional information. Proc Natl Acad Sci U S A 1998; 95: 14506-10.
61. Bennett C, Liang KC, McGaugh JL. Depletion of adrenal catecholamines alters the amnestic effect of amygdala stimulation. Behav Brain Res 1985; 15: 83-91.
62. Liang KC, McGaugh JL. Lesions of the stria terminalis attenuate the amnestic effect of amygdaloid stimulation on avoidance responses. Brain Res 1983; 274: 309-18.
63. Liang KC, Bennett C, McGaugh JL. Peripheral epinephrine modulates the effects of post-training amygdala stimulation on memory. Behav Brain Res 1985; 15: 93-100.
64. Stenberg DB, Gold PE. Retrograde amnesia produced by electrical stimulation of the amygdala: Attenuation with adrenergic antagonists. Brain Res 1981; 211: 59-65.
65. Quirarte GL, Roozendaal B, McGaugh JL. Glucocorticoid enhancement of memory storage involves noradrenergic activation in the basolateral amygdala. Proc Natl Acad Sci U S A 1997; 9: 14048-53.
66. Roozendaal B, Portillo-Márquez G, McGaugh JL. Basolateral amygdala lesions block glucocorticoid-induced modulation of memory for spatial learning. Behav Neurosci 1996; 110: 1074-83.
67. Roozendaal B, McGaugh JL. The memory-modulatory effects of glucocorticoids depend on an intact stria terminalis. Brain Res 1996; 709: 243-50.
68. Roozendaal B, McGaugh JL. Amygdaloid nuclei lesions differentially affect glucocorticoid-induced memory enhancement in an inhibitory avoidance task. Neurobiol Learn Mem 1996; 65: 1-8.
69. Roozendaal B, McGaugh JL. Basolateral amygdala lesions block the memory-enhancing effect of glucocorticoid administration in the dorsal hippocampus of rats. Eur J Neurosci 1997; 9: 76-83.
70. Roozendaal B, Sapolsky RM, McGaugh JL. Basolateral amygdala lesions block the disruptive effects of long-term adrenalectomy on spatial memory. Neuroscience 1998; 84: 453-65.
71. Cahill L, McGaugh, J.L. NMDA-induced lesions of the amygdaloid complex block the retention-enhancing effect of posttraining epinephrine. Psychobiology 1991; 19: 206-10.
72. Flood JF, Morley JE, Roberts E. Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: The amygdala is by far the most sensitive. Proc Natl Acad Sci U S A 1995; 92: 10806-10.
73. Liang KC, McGaugh JL. Lesions of the stria terminalis attenuate the enhancing effect of posttraining epinephrine on retention on an inhibitory avoidance response. Behav Brain Res 1983; 9: 49-58.
74. Liang KC, Juler RG, McGaugh JL. Modulating effects of posttraining epinephrine on memory: Involvement of the amygdala noradrenergic system. Brain Res 1986; 368: 125-33.
75. Liang KC, Chen LL, Huang TE. The role of amygdala norepinephrine in memory formation: Involvement in the memory enhancing effect of peripheral epinephrine. Chin J Physiol 1995; 38: 81-91.
76. Ellis ME, Berman RF, Kesner RP. Amnesia attenuation specificity: Propanolol reverses norepinephrine but not cycloheximide-induced amnesia. Pharmacol Biochem Behav 1983; 19: 733-6.
77. Ferry B, McGaugh JL. Clenbuterol administration into the basolateral amygdala post-training enhances retention in an inhibitory avoidance task. Neurobiol Learn Mem 1999; 72: 8-12.
78. Hatfield T, McGaugh JL. Norepinephrine infused into the basolateral amygdala posttraining enhances retention in an a spatial water maze task. Neurobiol Learn Mem 1999; 71: 232-9.
79. Introini-Collison IB, Miyazaki B, McGaugh JL. Involvement of the amygdala in the memory-enhancing effects of clenbuterol. Psychopharmacology 1991; 104: 541-4.
80. Roozendaal B, Koolhaas JM, Bohus B. Posttraining norepinephrine infusion into the central amygdala differentially enhances later retention in Roman high-avoidance and low-avoidance rats. Behav Neurosci 1993; 107: 575-9.
81. Ammassari-Teule M, Pavone F, Castellano C, McGaugh JL. Amygdala and dorsal hippocampus lesions block the effects of GABAergic drugs on memory storage. Brain Res 1991; 551: 104-9.
82. Da CunhaC, Roozendaal B, Vazdarjanova A, McGaugh JL. Microinfusions of flumazenil into the basolateral but not the central nucleus of the amygdala enhance memory consolidation in rats. Neurobiol Learn Mem 1999; 72: 1-7.
83. Dickinson-Anson H, McGaugh JL. Bicuculline administered into the amygdala after training blocks benzodiazepine-induced amnesia. Brain Res 1997; 752: 197-202.
84. Izquierdo I, Da Cunha C, Huang CH, Walz R, Wolfman C, Medina JH. Post-training down-regulation of memory consolidation by a GABA-A mechanism in the amygdala modulated by endogenous benzodiacepines. Behav Neural Biol 1990; 54: 105-9.
85. Jerusalinsky D, Quillfeldt JA, Walz R, Da Silva RC, Bueno E, Silva M, et al. Effect of the infusion of the GABA-A receptor agonist, muscimol, on the role of the entorhinal cortex, amygdala, and hippocampus in memory processes. Behav Neural Biol 1994; 61: 132-8.
86. Salinas JA, McGaugh JL. The amygdala modulates memory for changes in reward magnitude: involvement of the amygdaloid GABAergic system. Behav Brain Res 1996; 1-2: 87-98.
87. 3 antagonist (BRL 46470A) injected into the basolateral amygdala, as opposed to diazepam. Behav Brain Res 1993; 59: 141-5.
88. Souza-Silva MA, Tomaz C. Amnesia after diazepam infusion into the basolateral but not central amygdala of Rattus norvegicus. Neuropsychobiology 1995; 32: 21-36.
89. Tomaz C, Dickinson-Anson H, McGaugh JL. Basolateral amygdala lesions block diazepam-induced anterograde amnesia in an inhibitory avoidance task. Proc Natl Acad Sci U S A 1992; 89: 3615-9.
90. Tomaz C, Dickinson-Anson H, McGaugh JL, Souza-Silva MA, Viana MB, Graeff FG. Localization in the amygdala of the amnestic action of diazepam on emotional memory. Behav Brain Res 1993; 58: 99-105.
91. Wolfman C, Da Cunha C, Jerusalinsky D, Levi de Stein M, Viola H, Izquierdo I, et al. Habituation and inhibitory avoidance training alter brain regional levels of benzodiacepine-like molecules and are affected by in-tracerebral flumazenil microinjection. Brain Res 1991; 548: 74-80.
92. Gallagher M, Rapp PR, Fanelli RJ. Opiate antagonist facilitation of time-dependent memory processes: Dependence upon intact norepine-phrine function. Brain Res 1985; 347: 284-90.
93. Introini-Collison IB, Nagahara AH, McGaugh JL Memory-enhancement with intra-amygdala posttraining naloxone is blocked by concurrent administration of propanolol. Brain Res 1989; 476: 94-101.
94. Introini-Collison IB, Ford L, McGaugh JL. Memory impairment induced by intra-amygdala beta-endorphin is mediated by noradrenergic influences. Neurobiol Learn Mem 1995; 63: 200-5.
95. McGaugh JL, Introini-Collison IB, Juler RG, Izquierdo I. Stria terminalis lesions attenuate the effects of posttraining naloxone and beta-endorphin on retention. Behav Neurosci 1986; 100: 839-44.
96. McGaugh JL, Introini-Collison IB, Nagahara AH. Memory-enhancing effects of posttraining naloxone: involvement of beta-noradrenergic influences in the amygdaloid complex. Brain Res 1988; 446: 37-49.
97. Dalmaz C, Introini-Collison IB, McGaugh JL. Noradrenergic and cholinergic interactions in the amygdala and the modulation of memory storage. Behav Brain Res 1993; 58: 167-74.
98. Introini-Collison IB, Baratti CM. Memory-modulatory effects of centrally acting noradrenergic drugs: Possible involvement of brain cholinergic mechanisms. Behav Neural Biol 1992; 5-7: 248-55.
99. Introini-Collison IB, Dalmaz C, McGaugh JL. Amygdala beta-noradrenergic influences on memory storage involve cholinergic activation. Neurobiol Learn Mem 1996; 65: 57-64.
100. Introini-Collison IB, Arai Y, McGaugh JL. Stria terminalis lesions attenuate the effects of posttraining oxotremorine and atropine on retention. Psychobiology 1989; 17: 397-401.
101. Torras-García M, Costa-Miserachs D, Portell-Cortés I, Morgado-Bernal I. Posttraining epinephrine and memory consolidation in rats with different basic learning capacities. The role of the stria terminalis. Exp Brain Res 1998; 121: 20-8.
102. Parent MB, McGaugh JL. Posttraining infusion of lidocaine into the amygdala basolateral complex impairs retention of inhibitory avoidance training. Brain Res 1994; 661: 97-103.
103. Ikegaya Y, Saito H, Abe K. Requirement of basolateral amygdala neuron activity for the induction of long-term potentiation in the dentate gyrus in vivo. Brain Res 1995; 671: 351-4.
104. Ikegaya Y, Nakanishi K, Saito H, Abe K. Amygdala beta-noradrenergic influence on hippocampal long-term potentiation in vivo. Neuroreport 1997; 8: 3143-6.
105. Packard MG, Cahill L, McGaugh JL. Amygdala modulation of hippocampal-dependent and caudate-dependent memory processes. Proc Natl Acad Sci USA 1994; 92: 8477-81.